| Publication |
Title |
PubMed |
Crossref |
Keywords |
| Segman-Magidovich et al. J Phys Chem B (2025) |
The Effects of Template Rigidity and Amino Acid Type on Heterogeneous Calcium-Phosphate Mineralization by Langmuir Films of Amphiphilic and Acidic beta-Sheet Peptides |
22877365
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Crossref |
|
| Lo Cascio et al. Commun Biol (2025) |
Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities |
39809992
|
Crossref |
|
| Suciu et al. Appl Intell (2025) |
A Nash equilibria decision tree for binary classification |
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Crossref |
|
| Alam et al. J Inorg Biochem (2025) |
Interactions of Li+ ions with NCS1: A potential mechanism of Li+ neuroprotective action against psychotic disorders |
39447483
|
Crossref |
Calcium signaling | EF-hands | Neuronal calcium sensor 1 | Neuronal calcium sensors | Neuroprotection | lithium
|
| Munawaroh et al. Int J Biol Macromol (2025) |
Enzyme Engineering for Chemical Synthesis and Water Absorbing Performance |
36642356
|
Crossref |
Antidiabetic | Crosslinking | Fish skin | Gelatin hydrogel | Glutaraldehyde
|
| Mignon et al. The Three Functional States of Proteins (2025) |
Fuzzy complexes |
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Crossref |
|
| Hidayat et al. J Mol Struct (2025) |
Molecular interaction of a protease inhibitor, leupeptin, with human serum albumin: Insights from calorimetry, spectroscopy, microscopy, and computational… |
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Crossref |
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| Lychko et al. Mater Adv (2025) |
Kinetics of charge-dependent reversible condensation of reflectin nanostructures |
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Crossref |
|
| Mignon et al. Protein Expr Purif (2025) |
Purification and characterization of the intrinsically disordered Arabidopsis thaliana protein SOG1 |
39892530
|
Crossref |
Arabidopsis thaliana | DNA damage response | Intrinsic disorder | NAC transcription factor | SOG1 | Solubility | protein purification
|
| Aguiar et al. Talanta (2025) |
Recombinant bovine serum albumin domain II as bioreceptor for ochratoxin A capture |
39489069
|
Crossref |
BSA domain II | Bioreceptor | Ochratoxin A | Recombinant protein | Solid-phase extraction
|
| Basmenj et al. Heliyon (2025) |
Computational epitope-based vaccine design with bioinformatics approach; a review |
39866399
|
Crossref |
|
| Buchko et al. Arch Oral Biol (2025) |
Ameloblastin binding to biomimetic models of cell membranes–A continuum of intrinsic disorder |
39514919
|
Crossref |
Ameloblastin | Amelogenesis | Biomineralization | Enamel formation | Lipids | Transient structure
|
| Khurshid et al. Steroids (2025) |
Unraveling binding interactions between methasterone and bovine serum albumin (BSA): A spectroscopic and computational study |
39983858
|
Crossref |
Anabolic-androgenic | Bovine serum albumin | Circular dichroism | Methasterone | Quenching
|
| Sumarokova et al. Int J Mol Sci (2025) |
SARS-CoV-2 FP1 Destabilizes Lipid Membranes and Facilitates Pore Formation |
39859399
|
Crossref |
AFM | SARS-CoV-2 | fusion peptide | lipid bilayer | membrane pore
|
| Radman et al. Int J Biol Macromol (2025) |
Conformational change induced by binding of Mn2+ ions activates SloR transcription factor in Streptococcus mutans |
39701257
|
Crossref |
Allostery | Manganese metallosensors | Metal ion homeostasis | Transcriptional factor SloR
|
| Bhardwaj et al. Nanoscale (2025) |
Nanoscale size impact of nanoparticle interaction and activity studies with urease |
39844696
|
Crossref |
|
| Ho et al. ACS Omega (2025) |
Aromatic Residue F443 Modulates the Dimer Interface and Activity of Pseudomonas mandelii Glutathione Reductase |
40060842
|
Crossref |
|
| Rial et al. Int J Biol Macromol (2025) |
Elucidating the physicochemical interactions between fibrinogen and surfactant mixtures: Implications for pharmaceutical sciences |
39855519
|
Crossref |
CTAB | Dicloxacillin | Fibrinogen | Molecular docking | Protein-ligand interaction | Spectroscopic analysis
|
| Liu et al. Food Hydrocoll (2025) |
Different polyphenols on cold plasma-induced covalent ovalbumin-polyphenols conjugates and affecting the antigenicity of OVA and its functionalities |
|
Crossref |
|
| Yousefi et al. J Mol Liq (2025) |
Elucidation on the interaction between ascorbic acid and beta-lactoglobulin based on multi-spectroscopic analysis and molecular simulation approach |
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Crossref |
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| Philip et al. J Phys Chem B (2025) |
Protein Silencing with Self-Peptides |
39949078
|
Crossref |
|
| Yue et al. J Phys Chem B (2025) |
Studying the Signaling Mechanism of Neuropilin-1s Intracellular Disorder Region via Conformational Mining and Dynamic Interaction Characterization |
39993015
|
Crossref |
|
| Miller et al. Chem Sci (2025) |
Cu (ii) binding to an antimicrobial shrimp peptide–a small step for structural chemistry, a big leap for medicinal applications |
39886434
|
Crossref |
|
| Biswas et al. J Lipid Res (2025) |
Competitive displacement of lipoprotein lipase from heparan sulfate is orchestrated by a disordered acidic cluster in GPIHBP1 |
39814316
|
Crossref |
ANGPTL4 | PSCK3 cleavage | competitive displacement | intrinsically disordered regions | lipase/lipoprotein | lipolysis and fatty acid metabolism | polyelectrolytes | transport
|
| Shen et al. Food Chem (2025) |
Transglutaminase-mediated glycation and crosslinking of beta-lactoglobulin: Effect of amino-saccharides on rheological, thermal, and gelling properties |
39994928
|
Crossref |
Chitosan oligosaccharide | Functional property. | Glucosamine | Glycation | Transglutaminase | beta-Lactoglobulin
|
| Mukherjee et al. ACS Infect Dis (2025) |
AHM-1: An Inclusion to the Arsenal of beta-Lactam Resistance in Clostridioides difficile |
39916534
|
Crossref |
B3-like MBL | Clostridioides difficile | MBL fold metallo hydrolase | nosocomial infection | beta-lactamase
|
| Neupane et al. Biochemistry (2025) |
Multiple Copper Ions Bind to and Promote the Oligomerization of Huntingtin Protein with Nonpathological Repeat Expansions |
39984289
|
Crossref |
|
| Yang et al. PLoS Pathog (2025) |
Structures of two lyssavirus glycoproteins trapped in pre-and post-fusion states and the implications on the spatial-temporal conformational transition along… |
39970183
|
Crossref |
|
| Yang et al. J Agric Food Chem (2025) |
Insight into the Underlying Molecular Toxic Mechanisms of Cyantraniliprole and Broflanilide against Different Targets with Glutathione Transferase Phi8 from… |
40042057
|
Crossref |
broflanilide | cyantraniliprole | diamide insecticides | different target receptors | toxic effects
|
| Hu et al. J Environ Manage (2025) |
Oxidative stress induced by emerging halohydroxybenzonitrile disinfection byproducts and their binding interaction with catalase |
40037240
|
Crossref |
Binding interaction | DBPs | HHBNs | Molecular docking | Oxidative stress
|
| Dindar et al. ACS Chem Neurosci (2025) |
The Use of Natural Volatile Compounds on the Fibrillation Domain of Amyloid Beta (GSNKGAIIGLM) Towards Promising Agents to Combat Alzheimers Disease |
40059298
|
Crossref |
Alzheimer’s disease | Abeta (2535) peptide | cinnamaldehyde | phenylethyl alcohol | alfa-asarone | beta-caryophyllene
|
| Ni et al. Ultrason Sonochem (2025) |
Enhancement of physicochemical and techno-functional properties of soy protein isolate amyloid fibrils by moderate ultrasonic pretreatment |
39566339
|
Crossref |
Amyloid fibrils | Microscopic steps | Soy protein isolate | Techno-functional properties | Ultrasound
|
| Kuril et al. J Pept Sci (2025) |
A comprehensive guide for secondary structure and tertiary structure determination in peptides and proteins by circular dichroism spectrometer |
39135381
|
Crossref |
CD method development | secondary structure | tertiary structure | thermal study of proteins and peptides
|
| Huang et al. Plant-Based Proteins (2025) |
Secondary Structural Analysis Using Fourier Transform Infrared and Circular Dichroism Spectroscopy |
|
Crossref |
|
| Rajendran et al. J Mol Recognit (2025) |
Deciphering Saquinavir–Bovine Serum Albumin Interactions: Spectroscopic and Computational Insights |
39746215
|
Crossref |
bovine serum albumin | circular dichroism spectroscopy | fluorescence spectroscopy | inducedfit docking | intermolecular interaction | saquinavir
|
| Semwal et al. Acta Crystallogr F Struct Biol Commun (2025) |
Small-angle X-ray scattering of engineered antigen-binding fragments: the case of glycosylated Fab from the Mannitou IgM antibody |
39718025
|
Crossref |
Fabs | SEC-MALS | SEC-SAXS | SRCD | glycosylation
|
| Chiang et al. J Agric Food Chem (2025) |
Structural Insights into 4,5-DOPA Extradiol Dioxygenase from Beta vulgaris: Unraveling the Key Step in Versatile Betalain Biosynthesis |
40055856
|
Crossref |
betalains | betalamic acid | crystal structure | extradiol dioxygenase
|
| Dos Reis et al. Int J Biol Macromol (2025) |
Purification, characterization, and inhibition studies of a new acetylcholinesterase obtained from the neotropical brown stink bug Euschistus heros |
39662572
|
Crossref |
Acetylcholinesterase | Euschistus heros | Pesticide | Soybean | Stink bug
|
| Putri et al. J Biomol Struct Dyn (2025) |
A novel synthetic peptide analog enhanced antibacterial activity of the frog-derived skin peptide wuchuanin-A1 |
37968993
|
Crossref |
AMP | peptide analog | wuchuanin-A1
|
| Singh et al. The Microbe (2025) |
Truncation of the C-Terminal Domain from CgtA of Mycobacterium smegmatis reduces its ribosome binding property but increases its GTPase activity |
|
Crossref |
|
| Das et al. J Virol Methods (2025) |
Purification and characterization of kyasanur forest disease virus EDIII domain of major envelope glycoprotein |
39638261
|
Crossref |
Envelope protein | Flaviviruses | High yield expression | KFDV | Protein refolding | Subunit vaccines
|
| Ratre et al. Arch Microbiol (2025) |
Impact of ions, pH and the nature of substrate on the structure and activity of a robust single-stranded DNA binding (SSB)-like protein from Phi11 |
39812785
|
Crossref |
DNA binding | OB-fold | Phi11 | SSB-like | rGp13
|
| Sookai et al. J Mol Struct (2025) |
Binding Thermodynamics of 1, 3-bis (((E-1H-pyrrol-2-yl) methylene) amino) propan-2-ol palladium (II) with HSA and Its Intercalative Behaviour in ctDNA |
|
Crossref |
|
| Tan et al. Biochim Biophys Acta Gen Subj (2025) |
Computational analysis of the alpha 2 domain of apolipoprotein B 100, a potential triggering factor in LDL aggregation |
39681275
|
Crossref |
Ab initio structure prediction | Alpha2 domain | Amyloid fibril formation | Apolipoprotein B-100 | Atherosclerosis | LDL aggregation | Molecular dynamics simulation
|
| Páez-Pérez et al. BB Reports (2025) |
The C-terminal end of PLIN1 displays structural disorder |
|
Crossref |
|
| Paiva et al. Arch Biochem Biophys (2025) |
Exploring the structure and nucleic acid interactions of the Leishmania sp. telomerase reverse transcriptase N-terminal region |
39778669
|
Crossref |
Conservation degree | Leishmania | Nucleic acid-interactions | Structural features | TERT N-Terminal region
|
| Nazir et al. Proteins (2025) |
Rigidifying Flexible Sites: A Promising Strategy to Improve Thermostability of Lysophospholipase From Pyrococcus abyssi |
39888703
|
Crossref |
|
| Wang et al. Colloids Surf A Physicochem Eng Asp (2025) |
An eco-friendly rapid shrink-proofing finishing of wool fibers by protease based on substrate activation strategy |
|
Crossref |
|
| Resendes Barbosa et al. ChemMedChem (2025) |
Novel SulfonamideSydnone Hybrids: Complementary Insight into AntiInflammatory Action, AntiSARSCoV2 Activity, Human Serum Albumin Interaction, and in… |
39988470
|
Crossref |
Acute lung injury | Albumin | SARS-CoV-2 | Sulfonamides | Sydnones
|
| Singh et al. Arch Biochem Biophys (2025) |
The R337C mutation in the p53 oligomerization domain affects the regulatory domain and its ability to bind response elements: Evidence based on structural and… |
40064360
|
Crossref |
CD spectroscopy | Differential scanning calorimetry (DSC) | FTIR spectroscopy | p53 oligomerization domain mutant | tumor suppressor
|
| Coelho et al. Mater Today Chem (2025) |
Serum-PEG and BSA-PEG hydrogels as advanced platforms for evaluating plasma protein binding |
|
Crossref |
|
| Khan et al. J Mol Liq (2025) |
Influence of surfactants on association of cadmium sulfide nanoparticles with biomolecules |
|
Crossref |
|
| Pavia et al. Biomolecules (2025) |
The Diacylglycerol Acyltransferase 3 of Chlamydomonas reinhardtii Is a Disordered Protein Capable of Binding to Lipids Derived from Chloroplasts |
40001548
|
Crossref |
disordered protein | fluorescence | leakage | protein–lipid interactions | thylakoids
|
| Singh et al. Materials Advances (2025) |
Assessing dual drug 9-hydroxymethyl noscapine and telmisartan-loaded stearic acid nanoparticles against (H1299) non-small cell lung cancer and their… |
|
Crossref |
|
| Cheng et al. J Food Eng (2025) |
Protection of lipase by self-assembled microgels under high-pressure |
|
Crossref |
|
| Kardos et al. Protein Sci (2025) |
Guide to the structural characterization of protein aggregates and amyloid fibrils by CD spectroscopy |
39968955
|
Crossref |
Alzheimers disease | BeStSel | amyloid formation | amyloidbeta | circular dichroism spectroscopy | protein aggregation | secondary structure estimation
|
| Halder et al. Int J Biol Macromol (2025) |
Temperature dependent human serum albumin Corona formation: A case study on gold nanorods and nanospheres |
39689792
|
Crossref |
Conformation | Human serum albumin | Protein corona | Secondary structure | XPS
|
| Zhang et al. Int J Biol Macromol (2025) |
Enzymatically deamidated pork myofibrillar protein can form thermo-reversible gels |
39710023
|
Crossref |
Deamidation | Gel | Myofibrillar protein | Structure | Thermo-reversible
|
| Sulatsky et al. Int J Biol Macromol (2025) |
From protective enzyme to facilitator of amyloid propagation: Cathepsin D-mediated amyloid fibril fragmentation |
39952498
|
Crossref |
Amyloid fibril degradation | Amyloidosis and neurodegeneration | Anti-amyloid therapy | Degradation product toxicity | Lysosomal aspartyl protease cathepsin D (CTSD)
|
| Upadhyaya et al. J Phys Chem B (2025) |
Therapeutic Advantages of Nanoparticle-Impregnated Lysozyme Conjugates toward Amyloid-beta Fibrillation and Antimicrobial Activity |
39812393
|
Crossref |
|
| Mahato et al. ACS Appl Bio Mater (2025) |
Fabricating Silver Nanoparticles with Antidiabetic d-Pinitol to Restrict Amyloid Formation of Insulin |
39928478
|
Crossref |
Anti-amyloid silver nanoparticles | Antidiabetic | Insulin aggregation | Type II diabetes | d-Pinitol
|
| Lewis et al. Structure (2025) |
Mg2+-dependent mechanism of environmental versatility in a multidrug efflux pump |
39809273
|
Crossref |
|
| Chae et al. TMS 2025 154th Annual Meeting & Exhibition Supplemental Proceedings (2025) |
Rare Earth Elements Recovery Using Thermo-Responsive Virus |
|
Crossref |
|
| Shoara et al. J Biol Chem (2025) |
Structural analyses of apolipoprotein A-IV polymorphisms Q360H and T347S elucidate the inhibitory effect against thrombosis |
40074081
|
Crossref |
Apolipoprotein A-IV | Fibrinogen | Fluorescence anisotropy | Integrin alfaIIbbeta3 | Molecular docking | Molecular modeling | Platelet | Receptor structurefunction
|
| Sookai et al. Eur J Med Chem (2025) |
Cytotoxic pyrrole-based gold(III) chelates target human topoisomerase II as dual-mode inhibitors and interact with human serum albumin |
39904146
|
Crossref |
Therapeutic | NCI-60 | Topoisomerase | Albumin | DNA
|
| Omidkhah et al. Journal of Molecular Structure (2025) |
Synthesis, cytotoxicity, docking, MD simulation, drug-likeness, ADMET prediction and multi spectroscopic studies of some novel quinoline-4-carboxamide derivatives as DNA intercalating and anticancer agents |
|
Crossref |
Quinoline | Anticancer | DNA binding study | Spectroscopic studies | molecular dynamic (MD) | Docking
|
| Baffour et al. ACS Chem Neurosci (2025) |
Modulation of alfa-Synuclein Fibrillation and Toxicity by 4-Phenylbutyric Acid |
40020199
|
Crossref |
-
|
| Chatterjee et al. Plant Cell (2025) |
Maize unstable factor for orange1 encodes a nuclear protein that affects redox accumulation during kernel development |
39589935
|
Crossref |
-
|
| Li et al. Nanophotonics (2025) |
Metasurface-enhanced biomedical spectroscopy |
|
Crossref |
metasurface | biomedical spectroscopy | detection sensitivity; | infrared spectroscopy; | Raman spectroscopy
|
| Trivedi et al. FEBS J (2025) |
Psoralidin acts as a dual protease inhibitor against PLpro and Mpro of SARS-CoV-2 |
39745898
|
Crossref |
HCoV229E | PLpro | Psoralidin | SARSCoV2 | in vitro
|
| Ludwiczak et al. RSC Adv (2025) |
The influence of a dicationic surfactant on the aggregation process of the IVAGVN peptide derived from the human cystatin C sequence (56–61) |
39896427
|
Crossref |
|
| Prabakaran et al. Protein Mutations (2025) |
Chapter 1: Deciphering the modulatory role of mutations in protein aggregation through in silico methods |
|
Crossref |
Protein aggregation | prediction | kinetics | databases | molecular dynamics | review | amyloid
|
| Falcone et al. Biological and Medicinal Chemistry (2025) |
De novo designed beta-hairpin peptides mimicking the LPMO copper-binding histidine brace motif |
|
Crossref |
-
|
| Guo et al. J Pharm Biomed Anal (2025) |
Strategy for improving circular dichroism spectra deconvolution accuracy for macrocyclic peptides in drug discovery |
39298840
|
Crossref |
Circular dichroism deconvolution | Secondary structure | Macrocyclic peptides
|
| Sumsion et al. Biophys J (2025) |
Multiple structural states in an intrinsically disordered protein, SNAP-25, using circular dichroism |
39923128
|
Crossref |
-
|
| Qureshi et al. Journal of Molecular Structure (2025) |
A cobalt coordination complex binds on a unique binding site between domain-I and domain-III of serum albumin |
|
Crossref |
Drug binding site | Serum albumin | Biophysical chemistry | Metal ion coordination complex | Fluorescence quenching
|
| Vardaxi et al. Food Bioprocess Technol (2025) |
Structural and Colloidal Attributes of Protein Matrices Extracted from Renewable Resources and Evaluation of Their Film-Forming Capacity for Sustainable Food Packaging |
|
Crossref |
-
|
| Shi et al. Optics Letters (2025) |
Curved chirality distributions of optical vortices induced by photonic hooks |
|
Crossref |
-
|
| Yalimaimaiti et al. Processes (2025) |
A Glycopeptide from Agaricus balchaschensis Mitigates Cadmium Damage in Mice |
|
Crossref |
Agaricus balchaschensis | peptide-containing polysaccharide | structure
|
| Qi et al. Materials Advances (2025) |
Denatured bovine serum albumin particle decorated graphene oxide nanocomposite for ultrasensitive resistive humidity sensing |
|
Crossref |
-
|
| Dzyhovskyi et al. J Inorg Biochem (2025) |
Exploring divalent metal ion coordination. Unraveling binding modes in Staphylococcus aureus MntH fragments |
39549335
|
Crossref |
Copper(II) complexes; Iron(II) complexe | Metal-peptide complexes | MntH transporter | Staphylococcus aureus; | Zinc(II) complexes
|
| Kalaiselvi et al. Biochemical Engineering Journal (2025) |
Keratin-derived small peptides support the growth of endothelial and fibroblast cells and activate angiogenic signaling |
|
Crossref |
Goat hair | Keratin hydrolysat | Bioactive peptides | Angiogenesis | Tissue regeneration
|
| Baker et al. Protein Sci (2025) |
Proline variants in the BRCA1 coiled-coil domain disrupt folding and binding to PALB2 |
39673470
|
Crossref |
BRCA1 | PALB2 | circular dichroism | coiledcoil domains | isothermal titration calorimetry | protein–protein interaction | variants of unknown significance
|
| Elizabath et al. Small (2025) |
Monomers Versus Prenucleation Clusters En Route to Polymorphism of Supramolecular Polymers |
39491528
|
Crossref |
nucleation | pathway complexity | polymerization methods | prenucleation clusters | supramolecular polymorphism
|
| Brahma et al. Phys Chem Chem Phys (2025) |
Oxidative stress via UVC irradiation on the structural rearrangement of hen egg white lysozyme |
39688119
|
Crossref |
-
|
| Kuroi et al. Nanoscale Adv (2025) |
Protein corona formation on different-shaped CdSe/CdS semiconductor nanocrystals |
39650619
|
Crossref |
-
|
| Banerjee et al. Biomimetics (Basel) (2025) |
Design and Development of Natural-Product-Derived Nanoassemblies and Their Interactions with Alpha Synuclein |
39997105
|
Crossref |
alpha synuclein | cellular uptake | nanoassemblies | self-assembly | terpenes
|
| Diaz-Barreiro et al. Cell Commun Signal (2025) |
Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors |
39833821
|
Crossref |
Cytokine | Interleukin-1 family | Interleukin-38 | Receptor antagonist
|
| Liu et al. New Journal of Chemistry (2025) |
Effect of peptide secondary structure on calcium phosphate mineralization for bone regeneration |
|
Crossref |
-
|
| Nicholson et al. Green Chemistry (2025) |
Enhancing the reactivity of a P450 decarboxylase with ionic liquids |
|
Crossref |
-
|
| Novais et al. Process Biochemistry (2025) |
Evaluating the storage stability of a Plasmodium vivax circumsporozoite protein vaccine candidate |
|
Crossref |
Plasmodium vivax | Protein stability | Cold chain | Vaccine | Malaria
|
| Cheeseman et al. Advance Optical Material (2025) |
Nonlinear Vortex Dichroism in Chiral Molecules |
|
Crossref |
-
|
| Alpízar-Pedraza et al. Biochim Biophys Acta Biomembr (2025) |
Improving the antimicrobial potential of the peptide CIDEM-501 through acylation: A computational approach |
39788472
|
Crossref |
beta-Hairpin peptides | Antimicrobial activity | CIDEM-501 | Panusin | Molecular dynamic | Lipopeptides
|
| Ren et al. Langmuir (2025) |
Biphasic Coacervation Controlled by Kinetics as Studied by De Novo-Designed Peptides |
39811981
|
Crossref |
-
|
| Refaat et al. Int J Pharm (2025) |
Challenges with effective removal of surfactants from monoclonal antibody formulations |
39743160
|
Crossref |
Buffer exchange | Centrifugal concentrators | Excipients | Formulation screening | Monoclonal antibodies | Polysorbate removal
|
| Jang et al. Small (2025) |
NIR Light-Triggered Structural Modulation of Self-Assembled Prion Protein Aggregates |
39757410
|
Crossref |
activated carbon | nearinfrared light | prion protein | selfassembly
|
| Liu et al. Food Hydrocolloids (2025) |
Different polyphenols on cold plasma-induced covalent ovalbumin-polyphenols conjugates and affecting the antigenicity of OVA and its functionalities |
|
Crossref |
Protein-polyphenol interaction | IgE binding capacity | Antioxidant | Emulsifying property
|
| Kardos et al. Protein Sci (2025) |
Guide to the structural characterization of protein aggregates and amyloid fibrils by CD spectroscopy |
39968955
|
Crossref |
Alzheimers disease | BeStSel | amyloid formation | amyloidbeta | circular dichroism spectroscopy | protein aggregation | secondary structure estimation
|
| Zhen et al. J Control Release (2025) |
ROS-differentiated release of Apelin-13 from hydrogel comprehensively treats myocardial ischemia-reperfusion injury |
39842726
|
Crossref |
Apelin-13 | Controlled release | Ischemia-reperfusion injury | Reactive oxygen species | Responsive hydrogel
|
| Kawagoe et al. JACS Au (2025) |
Mechanistic Insights Into Oxidative Response of Heat Shock Factor 1 Condensate |
40017748
|
Crossref |
-
|
| Forfar et al. ACS Omega (2025) |
Single Amino Acid Changes Impact the Ability of Drosophila melanogaster Cecropins to Inhibit Growth of Providencia Pathogens |
39989784
|
Crossref |
-
|
| Florio et al. Inorg Chem (2025) |
A Half-Sandwich Os(II) Glucoconjugated NHC Complex as a Modulator of Amyloid Aggregation |
39945504
|
Crossref |
-
|
| Brichtová et al. Bioconjug Chem (2025) |
Effect of Lipidation on the Structure, Oligomerization, and Aggregation of Glucagon-like Peptide 1 |
39841169
|
Crossref |
-
|
| Martinez-Macias et al. ACS Omega (2025) |
“Allergolds”: Gold Nanocluster-Based Bioconjugates of Food Allergens with Reduced Immunoglobulin E Binding |
|
Crossref |
-
|
| Li et al. Food Chem (2025) |
An antifouling electrochemical sensor based on a U-shaped four-in-one peptide and poly(3,4-ethylenedioxythiophene) for vancomycin detection in fresh goat milk |
39241413
|
Crossref |
Antifouling | Food safety | Peptide | Sensor | Vancomycin
|
| Zhang et al. Cells (2025) |
The LSmAD Domain of Ataxin-2 Modulates the Structure and RNA Binding of Its Preceding LSm Domain |
40072111
|
Crossref |
Ataxin-2 | LSm | LSmAD | RNA binding | SHAPE | U-rich
|
| Zhang et al. ACS Nano (2025) |
Dual-Enzyme-Instructed Peptide Self-Assembly to Boost Immunogenic Cell Death by Coordinating Intracellular Calcium Overload and Chemotherapy |
39754594
|
Crossref |
calcium overload | cancer immunotherapy | chemotherapy | immunogenic cell death (ICD) | transient receptor potential cation channel subfamily V member 1 (TRPV1)
|
| Mahato et al. Nano Lett (2025) |
Pathway-Dependent Catalytic Activity of Short-Peptide-Based Metallozyme: From Promiscuous Activity to Cascade Reaction |
39893659
|
Crossref |
Amyloid | Cascade activity | Metallozyme | Pathway selection | Short peptide
|
| Pandit et al. ACS Nano (2025) |
Surface-Engineered Nanoparticles Enhance the Peroxidase Activity of Heme-Containing Proteins |
39932426
|
Crossref |
enzymes | gold nanoparticles | peptides | peroxidase | surface engineering
|
| Topuz et al. Food Hydrocolloids (2025) |
beta-lactoglobulin amyloid fibrils: Architecture, preparation, characterization, and potential applications |
|
Crossref |
-
|
| Albanese et al. Nat Rev Methods Primers (2025) |
Computational protein design |
|
Crossref |
-
|
| Li et al. Nat Comput Sci (2024) |
Decoupled peak property learning for efficient and interpretable ECD spectra prediction |
39753718
|
Crossref |
|
| Pasagadi et al. IEEE (2024) |
Atmospheric Cold Plasma Treatment of Whey: Insights Into Microbiological Quality and Structural Characteristics of Whey Proteins |
|
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Campylobacter jejuni (C. jejuni) | Heat shock protein 90alfa (Hsp90alfa) | Jejuni lipoprotein a (JlpA) | Protein-protein interaction
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Antibiotics | Insulin | Nano plastics | Protein | Secondary structure | Spectroscopic analysis
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DNA-binding IDPs | DNA-protection | Damage suppressor protein | Dsup | Intrinsically disordered proteins | Tardigrade
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Hyaluronic acid | Non-covalent complexation | O/W emulsion | Stability | Tilapia protein isolate
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Enzyme inhibition | Fluorescence quenching | Human saliva | Nano plastics | Polystyrene | Salivary alfa-amylase
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Anti-allergic activity | Mast cell stabilizing | Tea polysaccharide
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circular dichroism | lipid A phosphoethanolamine transferase | lipooligosaccharide | n-dodecyl beta-D-maltoside | sodium deoxycholate
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Structural insights into the disulfide isomerase and chaperone activity of TrbB of the F plasmid type IV secretion system |
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1H–15N heteronuclear single quantum coherence spectroscopy | Circular dichroism spectroscopy | ColabFold-AlphaFold2 | Disulfide isomerase | F-like type IV secretion system | Protein design | Small angle X-Ray scattering
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Ruminococcus flavefaciens | Trimodular enzyme | homology modeling | licheninase | molecular dynamic simulation
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Geobacillus kaustophilus encapsulin | Pyrococcus furiosus encapsulin | VUVCD
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DUF3055 from Staphylococcus aureus adopts unique strategy for structural distinctiveness |
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P151 | RHAMM | hyaluronan | peptide conformation | therapeutic peptide
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Conjugation with the Carrier Helped to Reveal acidification-Induced Structural Shift in the Peptide from Phospholipase Domain of Parvovirus B19 |
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Parvovirus B19 | Phospholipase A2 | Random coil to alpha helix transition | Synthetic peptides | Viral entrance
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First vertebrate BRICHOS antimicrobial peptides: beta-hairpin host defense peptides in limbless amphibia lung resemble those of marine worms |
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Antibiotic resistance | Antimicrobial peptides | BRICHOS domain | Caecilians | Peptide discovery | Pulmonary surfactant SP-C | beta-hairpin peptides
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ANS binding | Circular dichroism (CD) | Metal-binding | Molten globule | Platinum | SUMO1
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C4BP | Complement evasion | LcpA | Leptospira interrogans | Outer surface protein
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Circular dichroism spectroscopy | HIF-2alfa | Hypoxia | Protein purification | Refolding
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Exploring the Kinetics and Thermodynamics of a Novel Histidine Ammonia-Lyase from Geobacillus kaustophilus |
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FRET | Intrinsic fluorescence | PREP1 protein and peptides | amyloids | beta-structures
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Antimicrobial peptides | Elastin-like carriers | Gene design | Recombinant proteins
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Frataxin | Friedreich’s ataxia | Nqo15
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GABA | aldehyde dehydrogenases | chaperones | mitochondria | neurotransmitter diseases | protein folding
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Chaperone activity | Human alfaB-Crystallin | Protein oligomerization | Protein stability | p.R107L mutation
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generation of antibodies | membrane protein | molecular dynamics simulation | protein engineering | secondary structure
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The Human Paraoxonase 2: An Optimized Procedure for Refolding and Stabilization Facilitates Enzyme Analyses and a Proteomics Approach |
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biofilm | enzyme kinetics | lactonase | paraoxonase | quorum quenching
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Androctonus amoreuxi | Antimicrobial peptides | Antiviral peptides | COVID-19 | SARS-CoV-2 | Scorpion venom peptides | Spike protein - hACE2 interaction | Transcriptomic analysis
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Methylglyoxal-Induced Modifications in Human Triosephosphate Isomerase: Structural and Functional Repercussions of Specific Mutations |
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Synthesis of Temporin-SHa Retro Analogs with Lysine Addition/Substitution and Antibiotic Conjugation to Enhance Antibacterial, Antifungal, and Anticancer… |
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AMPs | antibacterial | anticancer | antifungal | antimicrobial peptides | levofloxacin | temporin-SHa
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Dengue serotypes | Envelope protein | Flaviviruses | High yield expression | Therapeutics | Vaccines
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Exploring a Potential Optimization Route for Peptide Ligands of the Sam Domain from the Lipid Phosphatase Ship2 |
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EphA2 receptor | Sam (Sterile alpha motif) domain | Ship2 lipid phosphatase | anticancer molecular tools | drug design | peptides
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Saponins Effect on Human Insulin Amyloid Aggregation |
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AL amyloidosis | amyloidogenesis | cardiomyopathy | constant domain | immunoglobulin light chains | proteolysis
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Staphylococcus aureus | DNA repair | RecA | antibiotic resistance | gallic acid | recombination
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(beta/alfa)8-barrel | DeNovoTIMs | TIM barrel | additive effects | asymmetry | de novo protein design | protein folding
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diterpene synthase | enzyme mechanism | natural product biosynthesis | plant biochemistry | plant specialized metabolism | protein crystallization | terpenoid
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Deciphering the Monomeric and Dimeric Conformational Landscapes of the Full-Length TDP-43 and the Impact of the C-Terminal Domain |
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SDS | biophysical characterization | fluorescence spectroscopy | metals | nuclease | tyrosyl radical
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Conformational networks | Molecular docking | Ovalbumin | Spectrofluorimetric methods | Surfactant mixtures
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Longchain fatty acids block allergic reaction against lipid transfer protein Sola l 7 from tomato seeds |
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IgE binding | NMR | Sola l 7 | free fatty acids | protein structure | tomato allergy | tomato seeds
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IAPP | amylin | amyloid | ganglioside | lipid
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Identification of a Hidden, Highly Aggregation-Prone Intermediate of Full-Length TDP-43 That Triggers its Misfolding and Amyloid Aggregation |
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Development of Nontoxic Peptides for Lipopolysaccharide Neutralization and Sepsis Treatment |
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Circular dichroism | Cyclic voltammetry | Haemoglobin | MD simulations | Static quenching | Thifluzamide | Time resolved fluorescence spectroscopy | UV–visible spectroscopy
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Ice-binding protein, Antifreeze protein, Cryopreservation, Chemical stability, Cold denaturation, DUF3494, Ice recrystallization inhibition, Thermal hysteresis
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Delivery system | Exosomes | Extracellular Vesicles | Protein encapsulation | STAT3
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A cysteine-specific solubilizing tag strategy enables efficient chemical protein synthesis of difficult targets |
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Tuning Supramolecular Chirality in Iodinated Amphiphilic Peptides Through Tripeptide Linker Editing |
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Gyrase inhibitor | Insect cell expression | Toxin-antitoxin | Unfolding-refolding
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Fluidity regulation | Lactic acid bacteria | Lipochaperone activity | Small Heat Shock Protein | Structural modification pointmutation
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Mining human microbiomes reveals an untapped source of peptide antibiotics |
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Transthyretin-Penetratin: A Potent Fusion Protein Inhibitor against Alzheimers Amyloid-beta Fibrillogenesis with High Blood Brain Barrier Crossing Capability |
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Structural conservation in the glutathione binding in Sphingomonas sp. glutaredoxin Grx3 and variations for cold adaptation |
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Cation- interaction | Cis-proline loop | Cold adaptation | Glutaredoxin 3 | Hydrogen bond | Salt bridge | Thioredoxin fold
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Designing surface exposed sites on Bacillus subtilis lipase A for spin-labeling and hydration studies |
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Rational Design of Dual-Functionalized Gd@C82 Nanoparticles to Relieve Neuronal Cytotoxicity in Alzheimers Disease via Inhibition of Abeta Aggregation |
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Alzheimer’s disease | aggregation inhibitor | functionalized Gd@C82 nanoparticle | rational design | restore synaptic loss
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Functional characterisation and modification of a novel Kunitzin peptide for use as an anti-trypsin antimicrobial peptide against drug-resistant Escherichia coli |
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Anti-endotoxin | Antimicrobial peptides | Drug resistance | Peptide modification | Proteolytic tolerance
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Mapping Full Conformational Transition Dynamics of Intrinsically Disordered Proteins Using a Single-Molecule Nanocircuit |
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biosensor | conformational transition | intrinsically disordered protein | silicon nanowire | single-molecule dynamics
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Designing Analogs of SAAP-148 with Enhanced Antimicrobial and Anti-LPS Activities |
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Lys-scan | SAAP-148 | antimicrobial activity | antimicrobial peptides | cytotoxicity
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Structural conversion of the spidroin C-terminal domain during assembly of spider silk fibers |
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Utilizing dry-heating maillard reaction approach to modify the functional and structural properties of ultrasound pretreated sunnhemp protein isolate with dextran |
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Location Is Everything: Influence of His-Tag Fusion Site on Properties of Adenylosuccinate Synthetase from Helicobacter pylori |
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Helicobacter pylori | His-tag | adenylosuccinate synthetase | enzyme kinetics | protein stability | protein structure
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Disordered regions in proteusin peptides guide post-translational modification by a flavin-dependent RiPP brominase |
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Molecular characterization of the interaction between human IgG and the M-related proteins from Streptococcus pyogenes |
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Group A Streptococcus | M protein family | M-related protein | Streptococcus pyogenes | binding affinity | binding stoichiometry | immunoglobulin G | pathogenesis
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Improving the solubility of wheat gluten: Establishing and characterizing wheat gluten-phosvitin complex at molecular and subunit levels |
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Inhibition of protein-protein interactions using biodegradable depsipeptide nanoassemblies |
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Biodegradable | Depsipeptide | Peptide inhibitor | Protein-protein interactions | Self-assembly
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+1 nucleosome | DNA sliding | H2A.Z | SWR1 | chromatin remodeler | cryo-EM | histone acetylation | histone exchange
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Adhesin | Host-pathogen interaction | Leptospira | Leptospirosis | Leucine rich repeats | Recombinant proteins
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Multiphosphorylation-Dependent Recognition of Anti-pS2 Antibodies against RNA Polymerase II C-Terminal Domain Revealed by Chemical Synthesis |
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Structural and functional modification of miscellaneous beans protein by high-intensity ultrasound: Mechanism, processing, and new insights |
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The Landscape of Osteocalcin Proteoforms Reveals Distinct Structural and Functional Roles of Its Carboxylation Sites |
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Antagonistic interactions between phage and host factors control arbitrium lysis–lysogeny decision |
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Peptides from non-immune proteins target infections through antimicrobial and immunomodulatory properties |
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Computational and physicochemical insight into 4-hydroxy-2-nonenal induced structural and functional perturbations in human low-density lipoprotein |
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4-hydroxy-2-nonenal | Low-density lipoprotein | aggregation | lipid peroxidation | oxidative stress | reactive oxygen species
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Plasma Sterilization for Bacterial Inactivation: Studies on Probable Mechanisms and Biochemical Actions |
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Structural insights into the interactions of repositioning and known drugs for Alzheimers disease with hen egg white lysozyme by MM-GBSA |
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Congo Red | MM-GBSA | Protein fibrillation | ThioflavinT | drug repositioning
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Second-Generation Phage Lambda Platform Employing SARS-CoV-2 Fusion Proteins as a Vaccine Candidate |
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SARS-CoV-2 | nanomedicine | phage-like particles | vaccine development | viral nanoparticles
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Structure and Function of Fermentation-Derived Bovine Lactoferrin Produced from Komagataella phaffii |
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biosimilarity | precision fermentation | recombinant bovine lactoferrin
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Plasmodium falciparum Alba6 exhibits DNase activity and participates in stress response |
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Biochemistry | Drugs | Microbiology parasite | Structural biology
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Mechanistic insights into CrCEP1: A dual-function cysteine protease with endo-and transpeptidase activity |
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Activity-based probes | Green algae | Papain-like cysteine protease | Proteolysis | Transpeptidation
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The novel anti-fibrillary effects of volatile compounds alfa-asarone and beta-caryophyllene on tau protein: Towards promising therapeutic agents for Alzheimers disease |
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Alzheimers disease | Tau fibrillation | alfa-Asarone | beta-Caryophyllene
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Extraction, purification, structural identification, and anti-senescent activity of novel pearl peptides on human dermal fibroblasts |
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Anti-senescent activity | Human dermal fibroblasts | Pearl peptides | Structural identification | Ultrasonic-assisted acetic acid extraction strategy
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New LsrK Ligands as AI-2 Quorum Sensing Interfering Compounds against Biofilm Formation |
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ATP-dependent conformational dynamics in a photoactivated adenylate cyclase revealed by fluorescence spectroscopy and small-angle X-ray scattering |
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Self-Assembling Peptides for Vaccine Adjuvant Discovery |
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Improvement of protein extraction from sunflower oil cake using ascorbic acid and N-acetylcysteine: Effects on chemical, structural, and functional properties |
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Formation of soy protein nanoparticles with varied loading capacity by controlled enzymatic hydrolysis and their co-assembly with Vitamin D3 |
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Analytical approaches for assessing protein structure in protein-rich food: A comprehensive review |
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Conformation | Detection methods | Food protein | Structure
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Production and characterization of amaranth amyloid fibrils from food protein waste |
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Backbone 1H, 13C, and 15N chemical shift assignments for human SERF2 |
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Amyloid | NMR | Paramagnetic relaxation enhancement | SERF | alfa-Synuclein
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Computational Design of Phosphotriesterase Improves VAgent Degradation Efficiency |
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Generative beta-hairpin design using a residue-based physicochemical property landscape |
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Design and synthesis of peptides as stabilizers of histone deacetylase 4 |
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Synthetic carbohydrate-binding module-endogalacturonase chimeras increase catalytic efficiency and saccharification of lignocellulose residues |
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Characterization of Structural Properties and Antimicrobial Activity of the C3f Peptide of Complement System |
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C3f | Zn2+ | antimicrobial peptides | circular dichroism | complement | innate immunity | pH-dependent activity
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2Pyridone Formation: An Efficient Method for the SolidPhase Synthesis of Homodimers |
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Homodimer | Pyridone | Solid-phase synthesis | peptide
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Oxidative refolding by Copper-catalyzed air oxidation consistently increases the homogeneity and activity of a Novel Interleukin-2 mutein |
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Copper-catalyzed air oxidation | Disulfide bond formation | Inclusion body | Interleukin 2 mutein | Oxidative refolding | Protein characterization
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Phloretin Targets Polyphosphate Kinase 1 to Attenuate Acinetobacter baumannii Virulence and Persistence In Vitro and In Vivo |
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A staphylococcal capsule-producing enzyme that unfolds via multiple intermediates predominantly exists as the trimers at low concentrations |
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CapG | intermediate | oligomer | structure | unfolding
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| Ito et al. Biochem Biophys Res Commun (2024) |
Effects of bound nucleotides on the secondary structure, thermal stability, and phosphorylation of Rab3A |
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Circular dichroism | Differential scanning fluorimetry | Leucine-rich repeat kinase 2 | Parkinsons disease | Phosphorylation | Rab3A
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Dynamics and thermal stability of the bypass polymerase, DinB homolog (Dbh) |
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Dbh | DinB homolog | NMR | Y-family polymerase | cold denaturation | dynamics | thermal stability
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A consensus recombinant elapid long-chain alfa-neurotoxin and how protein folding matters for antibody recognition and neutralization of elapid venoms |
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Antibodies | Elapid | Folding | Neurotoxin | Protein expression | Venom
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Decoding the Structure–Function Relationship of the Muramidase Domain in E. coli O157.H7 Bacteriophage Endolysin: A Potential Building Block for Chimeric… |
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Bacteriophage | Endolysin | Enzybiotic | Muramidase | Protein engineering | Protein modeling
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Key charged residues influence the amyloidogenic propensity of the helix-1 region of serum amyloid A |
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AA amyloidosis | Circular dichroism spectroscopy | Fourier transform infrared spectroscopy | Mechanism of aggregation | Serum amyloid a | Thioflavin T fluorescence assay
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Ligand fishing approach to explore Amaryllidaceae alkaloids as potential antiviral candidates targeting SARS-CoV-2 Nsp4 |
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Affinity-based assay | Amaryllidaceae alkaloids | Ligand fishing | Nsp4 protein | SARS-CoV-2
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Arg40 is critical for stability and activity of Adenylosuccinate lyase; a purine salvage enzyme from Leishmania donovani |
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Adenylosuccinate lyase | Drug target | Fluorescence spectroscopy | Leishmania | Molecular dynamics simulations | Purine salvage pathway
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Insight into the Effect of Methylglyoxal on the Conformation, Function, and Aggregation Propensity of alfaSynuclein |
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Aggregation | Human alfa-synuclein | Protein glycation | Synaptic vesicles | and Methylglyoxal
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Design and Escherichia coli Expression of a Natively Folded Multi-Disulfide Bonded Influenza H1N1-PR8 Receptor-Binding Domain (RBD) |
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E. coli expression system | H1N1 | NMR | disulfide bonds | influenza A | receptor-binding domain | refolding
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Senegalin-2: A Novel Hexadecapeptide from Kassina senegalensis with Antibacterial and Muscle Relaxant Activities, and Its Derivative Senegalin-2BK as a… |
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amphibian | antagonist | antimicrobial peptides | bradykinin | smooth muscle
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Structure-Dependent Water Responsiveness of Protein Block Copolymers |
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biomaterials | block copolymers | protein engineering | protein films | water-responsive materials
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Pathogenic Homocystinuria-Associated T236N Mutation Dramatically Alters the Biochemical Properties of Cystathionine Beta-Synthase Protein |
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circular dichroism | cystathionine beta-synthase | homocystinuria | mutation | pyridoxine non-responsiveness
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Characterization of intermediate states in the fibrillogenesis of odorant-binding proteins |
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Amorphous aggregates and amyloids | Fibrillogenesis | Odorant-binding proteins | On-pathway intermediates | beta-Barrel structure
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Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein |
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Enzymatic activity | Galactokinase | Leishmania donovani | Small-angle scattering
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The final walk with preptin |
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Crossref |
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Dynamic conformational changes of a tardigrade group-3 late embryogenesis abundant protein modulate membrane biophysical properties |
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conformational dynamics | intrinsically disordered proteins | late embryogenesis abundant proteins | protein–membrane interactions
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Effect of different oligomerization assemblies of conglutin on its interaction behavior with vitexin |
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fluorescence quenching | lupin seed | phenolic compound-protein interactions | thermodynamics | vitexin | -conglutin
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Yeast-derived high N-mannosylation modulates acyl chain length selectivity and biochemical properties of recombinant Cordyceps militaris lipase |
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The Impact of SNP-Induced Amino Acid Substitutions L19P and G66R in the dRP-Lyase Domain of Human DNA Polymerase beta on Enzyme Activities |
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DNA polymerase beta | DNA repair | enzymatic activity | single-nucleotide polymorphism
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Variant of uncertain significance Arg866Cys enhances disorderedness of h-BRCA1 (759-1064) region |
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2,2,2-Trifluoroethanol (TFE) | Breast cancer susceptibility gene 1 (BRCA1) | Hereditary breast cancer (HBC) | Intrinsically disordered proteins (IDPs) | Variants of unknown clinical significance (VUS)
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Characterization of the Arabidopsis thaliana chromatin remodeler DEK3 for its interaction with histones and DNA |
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Chromatin remodeler | Chromatin-associated protein | DEK | SAF
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SNP-Associated Substitutions of Amino Acid Residues in the dNTP Selection Subdomain Decrease Polbeta Polymerase Activity |
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DNA polymerase beta | DNA repair | enzymatic activity | single-nucleotide polymorphism
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Enhanced degradation of post-consumer polyethylene terephthalate (PET) wastes by fusion cutinase: Effects of anchor and linker peptides |
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Evaluation of the interaction between new trypanocide 1, 2, 4-triazolo-3-thiones with human serum albumin |
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Refolding dynamics and immunoinformatic insights into Vibrio cholerae OmpA, OmpK, and OmpV for vaccine applications |
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Detergents | Immunoinformatics | Outer membrane proteins | Protein refolding | Vibrio
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Discovery and Characterization of Two Folded Intermediates for Outer Membrane Protein TolC Biogenesis |
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TolC | antibiotic efflux | antibiotic resistance | outer membrane protein biogenesis | outer membrane protein folding
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Chondroitin sulfate, dermatan sulfate, and hyaluronic acid differentially modify the biophysical properties of collagen-based hydrogels |
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Biopolymers | Extracellular matrix | Microfluidics | Microstructure | Scaffold | Stiffness | Transport
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One-Step Synthesis for Orn-Val with High Molecular Weight and Low Polydispersity by Ugi Four-Component Condensation |
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MPE-Orn-Val-Cbz | Orn-Val | Ugi’4CC | molecular weight | polydispersity
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20-kDa accessory protein (P20) from Bacillus thuringiensis subsp. israelensis ISPC-12: Purification, characterization, solution scattering and structural analysis |
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Bacillus thuringiensis subsp. israelensis | Characterization | Cytolytic (Cyt) toxins | P20 | Structural modelling | X-ray scattering
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Binding characteristics of the major kratom alkaloid, mitragynine, towards serum albumin: Spectroscopic, calorimetric, microscopic, and computational investigations |
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Human serum albumin | Kratom | Ligand–protein interaction | Mitragynine | Spectroscopy
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Cytotoxic potential of novel selenolato-bridged manganese (I)-based CORM and its molecular interaction with human serum albumin and DNA through spectroscopic… |
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Functional amyloid fibrils of biofilm-forming marine bacterium Pseudomonas aeruginosa PFL-P1 interact spontaneously with pyrene and augment the biodegradation |
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Biofilm | Extracellular polymeric substances | Fluorescence quenching | Functional amyloid | Pseudomonas spp. | Pyrene
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pH-Dependent oligomerisation of -conglutin: A key element to understand its molecular mechanism of action |
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In vitro anticancer effects of recombinant anisoplin through activation of SAPK/JNK and downregulation of NFB |
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Fungal ribotoxin | MCF-7 | NFB | Recombinant anisoplin (rAnp) | SAPK/JNK | Sarcin ricin loop (SRL)
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Structural adaptations for carboxypeptidase activity in putative S9 acylaminoacyl peptidase from Bacillus subtilis |
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Acylaminoacyl | Carboxypeptidase | N-acylated | Prolyl oligopeptidase | S9bs
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DRGD-linked charged EKKE dimeric dodecapeptide: pH-based amyloid nanostructures and their application in lead and uranium binding |
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Structural determinants of odorant-binding proteins affecting their ability to form amyloid fibrils |
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Amorphous aggregates and amyloids | Fibrillogenesis | Odorant-binding proteins | beta-Barrel structure
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Degradation of pathogenic amyloids induced by matrix metalloproteinase-9 |
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The presence of NSAIDs may affect the binding capacity of serum albumin to the natural products hymecromone and umbelliferone |
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Biophysical characterization | Natural products | Protein-ligand interactions
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Characterization of DsrD and its interaction with the DsrAB dissimilatory sulfite reductase |
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DsrAB | DsrD | dissimilatory sulfite reductase | sulfatereducing bacteria | sulfur metabolism
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Biophysical characterization of the dystrophin C-terminal domain: Dystrophin interacts differentially with dystrobrevin isoforms |
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dystrobrevin | dystrophin | muscle proteins | muscular dystrophy | protein structure and function
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Design of human ACE2 mimic miniprotein binders that interact with RBD of SARS-CoV-2 variants of concerns |
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ACE2 mimics | SARS-CoV-2 | miniprotein | protein design | therapeutics | variant of concern
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Structural insights into the unique recognition module between alfasynuclein peptide and nanobody |
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Parkinsons disease | amyloids | nanobody | nanobody-peptide complex | peptide binding | structure determination | unique paratopes | alfa-synuclein
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Exploring the binding mechanism and esterase-like activity of human serum albumin with levofloxacin and its choline based conjugates: A biophysical approach |
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Esterase-like activity | Human serum albumin | Levofloxacin | Time resolved fluorescence spectroscopy
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Design of parallel sheet nanofibrils using Monte Carlo search, coarsegrained simulations, and experimental testing |
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DMD/PRIME20 simulations | amyloid betasheet fibrils | peptide assembly design | peptide selfassembly
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Fusion of amyloid beta with ferritin yields an isolated oligomeric beta-sheet-rich aggregate inside the ferritin cage |
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Synthesis, antimicrobial activity, and mechanistic studies of enterocin DD14, a leaderless two-peptide bacteriocin |
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Chemical synthesis | Cytotoxicity | Enterocin DD14 | Mode of action | Pore forming
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Enhancing the functionality of pea proteins by conjugation with propylene glycol alginate via transacylation reaction assisted with ultrasonication |
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Conjugation | Functional properties | Pea protein isolates | Propylene glycol alginate | Transacylation | Ultrasonication
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Clinically used drug arsenic trioxide targets XIAP and overcomes apoptosis resistance in an organoid-based preclinical cancer model |
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Isolation and characterization of DNA aptamers against the HlyE antigen of Salmonella Typhi |
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Salmonella Typhi | DNA aptamers | HlyE antigen | SELEX
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Cyclic-NDGA Effectively Inhibits Human -Synuclein Fibrillation, Forms Nontoxic Off-Pathway Species, and Disintegrates Preformed Mature Fibrils |
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IDP | amorphous aggregates | amyloid | cNDGA | fibrillation | -synuclein
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Anti-DENV-ED3 antibody cross-talks generate immune interference among the four DENVs |
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Oral administration of a recombinant modified RBD antigen of SARS-CoV-2 as a possible immunostimulant for the care of COVID-19 |
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Interaction mechanism of a cysteine protease inhibitor, odanacatib, with human serum albumin: In vitro and bioinformatics studies |
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Drug-protein binding | Fluorescence spectroscopy | Human serum albumin | Molecular docking | Odanacatib
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Enhanced Delivery of Biomolecules into Caco2 Cells Based on the Cell-Penetrating Ability of Keratin Peptides |
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biomolecules delivery | cell-penetrating ability | cellular uptake | keratin peptides | noncovalent bonding
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The hemostatic molecular mechanism of Sanguisorbae Radixs pharmacological active components based on HSA: Spectroscopic investigations, molecular… |
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HSA | Haemostasis | Molecular simulation | Multi-spectroscopy | Sanguisorbae Radix phenolic acid
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Exploring the impact of novel thiazole-pyrazole fused benzo-coumarin derivatives on human serum albumin: Synthesis, photophysical properties, anti-cholinergic… |
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Alzheimer’s disease | Drug-protein interaction | Fluorescence spectroscopy | Fused benzo-coumarin derivatives | Serum albumin
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Total Chemical Synthesis of the SARSCoV2 Spike ReceptorBinding Domain |
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Discovery of Selective Cyclic d-Sulfopeptide Ligands of the Chemokine CCL22 via Mirror-Image mRNA Display with Genetic Reprogramming |
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Identification of a cryptic functional apolipophorin-III domain within the Prominin-1 gene of Litopenaeus vannamei |
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Apolipophorin-3 | Lipid binding | Liposome | Litopenaeus vannamei | Prominin
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Molecular mechanisms for DNA methylation defects induced by ICF syndromelinked mutations in DNMT3B |
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DNA methylation | crystal structure | epigenetic modification | human disease
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Chiral Au (III) chelates exhibit unique NCI-60 cytotoxicity profiles and interactions with human serum albumin |
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Fabrication of stable spherical soybean lipophilic protein nanogel for curcumin delivery: Carbony oxygen and aromatic ring flexibility binding to the beta barrel |
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Helicity of a tardigrade disordered protein contributes to its protective function during desiccation |
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CAHS | anhydrobiosis | dehydration | desiccation tolerance | disordered protein | helicity | tardigrade
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Cu (II) binding to the 6aJL2-R24G antibody light chain protein associated with light chain amyloidosis disease: The role of histidines |
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Amyloidosis | Copper | Light chain
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| Wang et al. Int J Biol Macromol (2024) |
The weakened physiological functions of human serum albumin in presence of polystyrene nanoplastics |
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Binding mechanism | Conformation | Human serum albumin | Polystyrene nanoplastics
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Early microvascular coronary endothelial dysfunction precedes pembrolizumab-induced cardiotoxicity. Preventive role of high dose of atorvastatin |
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Atorvastatin | Cardio-oncology | Cardiotoxicity | Immune checkpoint inhibitors | Microvascular coronary endothelial dysfunction | Pembrolizumab
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Interaction between the antioxidant compound safranal and alfa-chymotrypsin in spectroscopic fields and molecular modeling approaches |
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kinetic | safranal | simulation | spectroscopy | alfa-Chy
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High-pressure microfluidisation positively impacts structural properties and improves functional characteristics of almond proteins obtained from almond meal |
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Almond de-oiled cake | CD spectra | Microfluidisation | PDCAAS | SDS-PAGE | SEM
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Spectroscopic and in silico characterization of the interaction between synthetic 2-substituted-naphtho-1, 4-quinones and human serum albumin |
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Exploring the therapeutic potential of rutin through investigating its inhibitory mechanism on lactate dehydrogenase: Multi-spectral methods and computer simulation |
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Computer simulation | Inhibition | Lactate dehydrogenase | Rutin | Spectroscopy
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Antibacterial action, proteolytic immunity, and in vivo activity of a Vibrio cholerae microcin |
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Vibrio cholerae | antibacterial | bacterial competition | bacteriocin | immunity protein | infectious disease | microcin | protease
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PEGylated SOCS3 mimetics encapsulated into PLGA-NPs as selective inhibitors of JAK/STAT pathway in TNBC cells |
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JAK/STAT pathway | SOCS3 protein | mimetic chimeric peptides | nanoparticles
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Exploring high hydrostatic pressure effects on anthocyanin binding to serum albumin and food-derived transferrins |
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Anthocyanin | Binding interaction | High pressure | Serum albumin | Transferrin
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Recombinant production and characterization of a metal ion-independent Lysophospholipase from a hyperthermophilic archaeon Pyrococcus abyssi DSM25543 |
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Characterization | Lysophospholipase | Metal ion-independency | P. abyssi
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Rapid Quantification of Protein Secondary Structure Composition from a Single Unassigned 1D 13C Nuclear Magnetic Resonance Spectrum |
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Analysis of the Structure of 14 Therapeutic Antibodies Using Circular Dichroism Spectroscopy |
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Benzethonium chloride affects short chain fatty acids produced from anaerobic fermentation of waste activated sludge: Performance, biodegradation and mechanisms |
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Anaerobic fermentation | Benzethonium chloride | Protein denaturation | Short chain fatty acids production
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Atmospheric cold plasma reduces Ara h 1 antigenicity in roasted peanuts by altering the protein structure and amino acid profile |
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Allergen Stability | Digestibility | Glycation | Immunoreactivity | Non-thermal plasma | Peanut allergy
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Biochemical investigation and engineering of a tardigrade X family DNA polymerase for template-independent DNA synthesis |
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Insight into the binding mechanisms of fluorinated 2-aminothiazole sulfonamide and human serum albumin: Spectroscopic and in silico approaches |
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Aminothiazole | Multispectral analysis | Pharmacokinetics
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Condensation of the N-terminal domain of human topoisomerase 1 is driven by electrostatic interactions and tuned by its charge distribution |
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Biomolecular condensates | Charge decoration | Charge patterning | Human topoisomerase 1 | Intrinsically disordered proteins
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Revisiting and updating the interaction between human serum albumin and the non-steroidal anti-inflammatory drugs ketoprofen and ketorolac |
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biophysical characterization | in silico calculations | non-steroidal anti-inflammatory drugs | pharmacokinetics | spectroscopy
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Development of mirror-image monobodies targeting the oncogenic BCR:: ABL1 kinase |
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Paracellular delivery of protein drugs with smart enteropatho nanoparticles |
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dual release | glycocalyx | nanoparticle | oral delivery | paracellular permeability | tight junction
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Increasing the polarity of beta-lapachone does not affect its binding capacity with bovine plasma protein |
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In silico calculations | Protein-ligand interactions | Spectroscopy
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Synthetic dimethoxyxanthones bind similarly to human serum albumin compared with highly oxygenated xanthones |
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Characterization of nanodisc-forming peptides for membrane protein studies |
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AEM28 | Cell membrane solubilization | NMR | Nanodisc fusion | P450-CPR redox complex | Peptide nanodisc | Peptide:lipid interaction
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Amyloid formation and depolymerization of tumor suppressor p16INK4a are regulated by a thiol-dependent redox mechanism |
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MoDAFold: a strategy for predicting the structure of missense mutant protein based on AlphaFold2 and molecular dynamics |
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MoDAFold | deep learning | missense mutant protein | molecular dynamics | protein structure prediction
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Interaction between a water-soluble anionic porphyrin and human serum albumin unexpectedly stimulates the aggregation of the photosensitizer at the surface of the… |
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Anionic porphyrin | HSA-binding | Photodynamic therapy
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Investigation on the effect of fluorescence quenching of calf thymus DNA by piperine: caspase activation in the human breast cancer cell line studies |
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breast cancer | calf thymus DNA | cell viability | circular dichroism | fluorescence spectroscopy | piperine
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The AD3 locus of synaptotagmin-1 C2 domains modulates domain stability |
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Unveiling the contribution of Osborne protein fractions to the physicochemical and functional properties of alkaline and enzymatically extracted green lentil proteins |
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Functional prediction and assignment of Clostridium botulinum type A1 operome: A quest for prioritizing drug targets |
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Morpholine Prevents the Formation of Aspartimide from beta-allyl ester aspartic acid during Fmoc Cleavage in SPPS of Stapled Peptides |
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Protein thermal stability in the undergraduate biochemistry laboratory: Exploring protein thermal stability with yeast alcohol dehydrogenase |
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Arrhenius plot | alcohol dehydrogenase | circular dichroism | protein aggregation | protein unfolding | secondary structure | turbidity
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Impact of imperfect data on protein secondary structure estimates from Far-UV circular dichroism spectra |
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BeStSel | Circular dichroism | Imperfect data | Robustness | Secondary structure | Spectral deconvolution
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Design, Synthesis and Catalytic Activity of Protein Containing Thiotyrosine as an Active Site Residue |
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aryl-thiols | biocatalysis | chemical protein synthesis | cyclic proteins | protein design
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| Martínez-Zacarias et al. Int J Mol Sci (2024) |
Effect of the Lys62Ala Mutation on the Thermal Stability of BstHPr Protein by Molecular Dynamics |
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BstHPr protein | molecular dynamics | molecular staple | mutant | salt bridge network | thermal stability | wild type
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Hybrid peptidePNA monomers as building blocks for the fabrication of supramolecular aggregates |
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bioimaging | fluorescence | peptide nucleic acids (PNA) | peptides | selfassembly
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Distinct Effects of SARSCoV2 Protein Segments on Structural Stability, Amyloidogenic Potential, and alfaSynuclein Aggregation |
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Aggregation | Intrinsically disordered proteins/regions | Peptides | Raman spectroscopy | SARS-CoV-2
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Design, synthesis and Anti-Plasmodial activity of Mortiamide-Lugdunin conjugates |
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Cyclic Peptides | Lugdunin | Mortiamides | Plasmodium falciparum
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First Generic Teriparatide: Structural and Biological Sameness to Its Reference Medicinal Product |
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comparative study | generic drug | peptide characterization | sameness | synthetic peptide | teriparatide
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Use of Synchrotron Radiation Circular Dichroism to Analyze the Interaction and Insertion of Proteins into Bacterial Outer Membrane Vesicles |
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Amyloid | Gram-negative bacteria | Membrane protein insertion | OMV: protein interaction | Outer membrane
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Powerful Protein Nanoreservoirs Based on Stellate Mesoporous Silica Embedded in Composite Hydrogels: From Burst Release to Retention |
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Application of singular value decomposition analysis: Insights into the complex mechanisms of amyloidogenesis |
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Amyloidogenesis | Abeta40 | R program | SVD | hIAPP
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Thermodynamics of oligomerization and Helix-to-sheet structural transition of amyloid beta-protein on anionic phospholipid vesicles |
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Amyloid-beta protein | Lipid vesicles | Membrane curvature | Oligomers | Phospholipid | Self-assembly
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PEGylation versus glycosylation: effect on the thermodynamics and thermostability of crisantaspase |
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Biobetter | L-asparaginase | PEGylation | glycosylation | thermodynamics | thermostability
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Chemical Modifications to Enhance the Drug Properties of a VIP Receptor Antagonist (ANT) Peptide |
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PEGylation | VIP | acute myeloid leukemia | peptide staple
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Determination of the role of specific amino acids in the binding of Zn (II), Ni (II), and Cu (II) to the active site of the M10 family metallopeptidase |
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Coordination chemistry | Metal binding domain | Metal-peptide complexes | Metallopeptidases | Point mutations study | Thermodynamic properties | Transition metal ions
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A Mechanistic Insight into the Structure, Conformational Dynamics, Affinity Profile and Energetics of Metanil Yellow-Serum Protein Complex |
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Protective effect of colchicine on albumin glycation and cellular oxidative stress: Insights into diabetic cardiomyopathy |
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albumin | colchicine | diabetic cardiomyopathy | glycation | oxidative stress
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Exploring the Potential of Biomimetic Peptides in Targeting Fibrillar and Filamentous Alpha-Synuclein—An In Silico and Experimental Approach to… |
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alpha-synuclein | antioxidant | fibrillation | molecular dynamics | peptides
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Biochemical and steady-state kinetic analyses of arsenate reductases from an arsenic-tolerant strain of Citrobacter youngae IITK SM2 |
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Arsenate-loaded goethite | Arsenate-reductase proteins (ArsC) | Arsenic | Citrobacter youngae IITK SM2 (CyIITKSM2) | Goethite | Process-based modeling | Reduction efficiency
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| Saha et al. FEBS J (2024) |
Structure–function analysis of nucleotide housekeeping protein HAM1 from human malaria parasite Plasmodium falciparum |
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Plasmodium falciparum | CRISPRCas9/DiCre | Xray crystallography | molecular dynamics | noncanonical bases
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| Shekhar et al. Chem Asian J (2024) |
Stabilizing Bifurcated Hydrogen Bond in 8Aminoquinoline Appended Peptides |
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8-Aminoquinoline | Bifurcated hydrogen bonding | CHO Hydrogen bond | Hirshfeld Surface analysis | NHN hydrogen bond
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A Novel Kunitz Trypsin Inhibitor from Enterolobium gummiferum Seeds Exhibits Antibiofilm Properties against Pathogenic Yeasts |
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antibiofilm | characterisation | circular dichroism | peptidase inhibitor
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The volatile constituents of rose, saffron and cardamom suppress the fibrillation of tau and not HEWL through the formation of non-toxic tau oligomers |
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The Role of Key Amino Acids of the Human Fe (II)/2OG-Dependent Dioxygenase ALKBH3 in Structural Dynamics and Repair Activity toward Methylated DNA |
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DNA methylation | DNA repair | circular dichroism | conformational dynamics | dioxygenase ALKBH3 | fluorescent spectroscopy | site-directed mutagenesis | stopped-flow method
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Rational design of structurebased vaccines targeting misfolded alphasynuclein conformers of Parkinsons disease and related disorders |
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Parkinsons disease | betasolenoid structure | parallel inregister betasheet structure | protein engineering | rational design | vaccine
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Enzymatic self-assembly/disassembly turns “ON”/“OFF” the mimetic hydrolytic activity of histidine nanofibers |
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Enhanced structure/function of mTSPO translocator in lipid: surfactant mixed micelles |
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Structural and functional characterisation of Maillard reaction products from casein-acid hydrolysate-sugars model system using multi-spectroscopic approach |
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Zein/Polysaccharide Nanoscale Electrostatic Complexes: Preparation, Drug Encapsulation and Antibacterial Properties |
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antibacterial | ciprofloxacin | nanoparticles | polysaccharides | zein
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Oxygen-selective regulation of cyclic di-GMP synthesis by a globin coupled sensor with a shortened linking domain modulates Shewanella sp. ANA-3 biofilm |
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Biofilm | Diguanylate cyclase | Globin | Heme | Oxygen sensing
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Unveiling a New Antimicrobial Peptide with Efficacy against P. aeruginosa and K. pneumoniae from Mangrove-Derived Paenibacillus thiaminolyticus NNS5… |
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Klebsiella pneumoniae | Mangrove | NNS5-6 | Paenibacillus thiaminolyticus | Pseudomonas aeruginosa | antimicrobial peptide | antimicrobial resistance | bacterial genome
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Biochemical characterization of paralyzed flagellum proteins A (PflA) and B (PflB) from Helicobacter pylori flagellar motor |
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Helicobacter pylori | bacterial flagellar motor | microbial motility | protein purification | protein refolding
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Human Serum Albumin in the presence of Small Platinum Nanoparticles |
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HSA | Nanomedicine | Platinum nanoparticles | Synchrotron radiation circular dichroism | Toxicity
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The effects of histidine substitution of aromatic residues on the amyloidogenic properties of the fragment 264–277 of nucleophosmin 1 |
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Amyloid aggregation | Histidine-mediated self-assembly | Novel self-assembling sequences | Nucleophosmin 1
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Activatable anticancer peptides with mutually suppressed bioactivity and their induced cytotoxicity by matrix metalloproteinase-2 |
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Structural and mechanistic insights into ALS patient derived mutations in D-amino acid oxidase |
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Amyotrophic Lateral Sclerosis | D-amino acid oxidase | Flavin Adenine Dinucleotide
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Insights into the Adsorption Mechanisms of the Antimicrobial Peptide CIDEM-501 on Membrane Models |
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antimicrobial peptides | molecular dynamics simulations | panulirin | panusin | beta-hairpin peptides | beta-sheet peptides
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Understanding the structural and functional changes and biochemical pathomechanism of the cardiomyopathy-associated p. R123W mutation in human alfaB… |
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Amyloid fibrils | Chaperone activity | Human alfaB-crystallin | Mutagenesis | Small heat shock protein (sHSP) | Structure analyses
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Tuning Molecular Motion Enhances Intrinsic Fluorescence in Peptide Amphiphile Nanofibers |
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Biomimetic Oil-in-Water Nanoemulsions as a Suitable Drug Delivery System to Target Inflamed Endothelial Cells |
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biomimetic nanocarrier | nano-emulsions | surface functionalisation
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Novel insights into whey protein peptide-iron chelating agents: Structural characterization, in vitro stability and functional properties |
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Operando spectroscopy investigations of the redox reactions in heme and heme-proteins |
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Exploring the Origins of Association of Poly (acrylic acid) Polyelectrolyte with Lysozyme in Aqueous Environment through Molecular Simulations and… |
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Fourier transform infrared spectroscopy | circular dichroism | complexation | molecular dynamics simulations | polyelectrolytes | proteins | secondary structure analysis | thermal treatment
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| Chang et al. Protein Sci (2024) |
Unraveling the underlying mechanisms of reduced amyloidogenic properties in human calcitonin via double mutations |
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amyloid formation | clinical replacement | human calcitonin | osteoporosis | peptide-based therapeutic drugs
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A trimeric glycosylated GH45 cellulase from the red abalone (Haliotis rufescens) exhibits endo and exoactivity |
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A comprehensive investigation of the interactions of human serum albumin with polymeric and hybrid nanoparticles |
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Capillary electrophoresis, human serum albumin | Metal-organic frameworks | Nanoparticle | PLGA | Protein stability | Synchrotron radiation circular dichroism
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Efficient biocatalytic conversion of ginsenoside Rd to M1 in a deep eutectic solvent system |
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Lipid–polymer hybrid-vesicles interrupt nucleation of amyloid fibrillation |
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Biocompatible Preparation of Beta-Lactoglobulin/Chondroitin Sulfate Carrier Nanoparticles and Modification of Their Colloidal and Hydropathic Properties by… |
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Tween 80 | bovine beta-lactoglobulin | electrostatic complexation | nanoparticles | porcine chondroitin sulfate | thermal treatment
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New perspective into the interaction behavior explore of Nano-berberine with alpha-lactalbumin in the presence of beta-lactoglobulin: Multi-spectroscopic and… |
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Functional and biochemical characterisation of remote homologues of type IV pili proteins PilN and PilO in Helicobacter pylori |
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Helicobacter pylori | bacterial flagellar motor | motility | oligomeric state | type IV pili
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Deciphering the dual nature of nesfatin-1: a tale of zinc ions Janus-faced influence |
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Gallus gallus | Chicken | Hormone | Intrinsically disordered protein | Metal cation binding protein | Metalloprotein | Nesfatins | Neuropeptide
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| Bargagna et al. Int J Mol Sci (2024) |
Defects in the Maturation of Mitochondrial Iron–Sulfur Proteins: Biophysical Investigation of the MMDS3 Causing Gly104Cys Variant of IBA57 |
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IBA57 | ISC machinery | ISCA2 | MMDS3 | iron–sulfur cluster biogenesis | iron–sulfur clusters | mitochondria | multiple mitochondrial dysfunctions syndrome
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6-Arene Ru(II) Complexes as Modulators of Amyloid Aggregation |
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Preferential Binding of Cations Modulates Electrostatically Driven Protein Aggregation and Disaggregation |
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The Production of PolysarcosineContaining Nanoparticles by RingOpening PolymerizationInduced SelfAssembly |
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amino acids | aqueous ringopening polymerization | nanoparticles | polymer morphology and secondary structure | polymerizationinduced selfassembly
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| Evangelista et al. Int J Biol Macromol (2024) |
Biomolecular condensates of Chlorocatechol 1, 2-Dioxygenase as prototypes of enzymatic microreactors for the degradation of polycyclic aromatic… |
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Biocondensates | Bioremediation | Cleavage of aromatic compounds | Dioxygenases | Liquid liquid phase separation
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Preparation and characterization of white shrimp hydrolysate–xylooligosaccharide Maillard products and their in vivo promotive effects of zinc absorption in mice |
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Chemical synthesis of site-selective advanced glycation end products in alfa-synuclein and its fragments |
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Modulating protein unfolding and refolding via the synergistic association of an anionic and a nonionic surfactant |
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Chiral SelfAssembly of a PyreneAppended Glutamylalanine Dipeptide and Its Charge Transfer Complex: Fabrication of MagnetoResponsive Hydrogels and… |
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cell imaging | charge transfer hydrogel | chiral hydrogel | magnetoresponsive | pyreneappended dipeptide
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The catalytic domain of free or ligand bound histone deacetylase 4 occurs in solution predominantly in closed conformation |
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Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc |
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Revealing the Improved Binding Interaction of Plant Alkaloid Harmaline with Human Hemoglobin in Molecular Crowding Condition |
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Effect of the aggregation state of amyloid-beta (25-35) on the brain oxidative stress in vivo |
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Nitroxyl Hybrids with Curcumin and Stilbene Scaffolds Display Potent Antioxidant Activity, Remodel the Amyloid Beta Oligomer, and Reverse Amyloid Beta… |
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Alzheimer’s disease | Abeta oligomer | EPR | amyloid beta peptide | antioxidant | bifunctional drug | electron paramagnetic resonance spectroscopy | nitroxide
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Pathogenic R163W Variant of the Copper Chaperone for Sod1 (Ccs) Functions as an Anti-chaperone |
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Engineered Cyclotide Blocks Neuronal Excitotoxicity |
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Enhancing quinoa (Chenopodium quinoa Willd) protein extraction: Alkaline solubilization coupled to isoelectric precipitation effects on structure, digestibility… |
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| Ali et al. Biochem J (2024) |
Identification of a 10-mer peptide from the death domain of MyD88 which attenuates inflammation and insulin resistance and improves glucose metabolism |
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cell penetrating peptide | diabetes | inflammation | insulin resistance
|
| Thakur et al. Int J Biol Macromol (2024) |
Alleviation of albumin glycation-induced diabetic cardiomyopathy by L-Arginine: Insights into Nrf-2 signaling |
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Diabetic cardiomyopathy | Glycation | L-arginine | Nrf-2 signaling
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Iridoid glycosides from noni (Morinda citrifolia L.) fruit pomace: A novel booster strategy for its extraction and will its alfa-glucosidase inhibitory be increased by… |
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Thermotolerance Mechanism of Fungal GH6 Cellobiohydrolase. Part I. Characterization of Thermotolerant Mutant from the Basidiomycete Phanerochaete… |
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GH6 | cellobiohydrolase | cellulose | circular dichroism | free cysteine | thermotolerance
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Investigating Cellulose Binding of Peptides Derived from Carbohydrate Binding Module 1 |
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| Beech et al. Protein Sci (2024) |
Understanding the stability of a plasticdegrading Rieske iron oxidoreductase system |
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Rieske oxygenase | circular dichroism | differential scanning calorimetry | dynamic light scattering | metalloenzyme | plastic bioconversion | polyethylene terephthalate | small angle xray scattering
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| Wang et al. Journal of Molecular Liquids (2024) |
Inhibitory mechanism of xanthine oxidase by 6-, 8-and 10-gingerol: Enzyme kinetics, multi-spectroscopy and molecular simulations |
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Conformational control of antimicrobial peptide amphiphilicity: consequences for boosting membrane interactions and antimicrobial effects of photocatalytic… |
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Combined techniques for revealing the mechanism beneath the inhibition effects of pectin on gluten digestibility using static in vitro gastro-duodenal protocols |
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Gastrointestinal | In vitro digestion | Pectin-gluten interactions
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In Situ ATR-FTIR Studies on the beta-Sheet Formation of Native and Regenerated Bombyx mori Silk Material in Solution and Its Potential for Drug Releasing Coatings |
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Design and Function of alfa-Helix-Rich, Heme-Binding Peptide Materials |
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In vitro and in vivo activities of scutellarein, a novel polyphosphate kinase 1 inhibitor against Acinetobacter baumannii infection |
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A. baumannii | Pathogenicity | Persistence | Polyphosphate | Polyphosphate kinase 1 | Scutellarein
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Zn2+ chelating peptide GFLGSP: Characterization of structure/Zn2+ chelating mode and the potential mechanisms for promoting Zn2+ transport in Caco-2… |
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Chelating characterization | Peptide-Zn(2+) complex | Transport mechanisms | Zn(2+) chelating peptide | Zn(2+) transport rate
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| Chen et al. Int J Biol Macromol (2024) |
Biophysical and biochemical characterization of a recombinant Lyme disease vaccine antigen, CspZ-YA |
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Buffer screening | E. coli | Lyme borreliae | Protein formulation | Recombinant protein vaccine
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LIKE EARLY STARVATION 1 interacts with amylopectin during starch biosynthesis |
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Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity |
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Single-step purification and characterization of Pseudomonas aeruginosa azurin |
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Azurin | Glutathione S-Transferase | HRV 3C protease | Molecular dynamics | Protein purification | Redox reaction
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Surface Modification of Ultrasonic Cavitation by Surfactants Improves Detection Sensitivity of alfa-Synuclein Amyloid Seeds |
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Parkinson’s disease | amyloid formation | primary nucleation | ultrasonication | alfa-Synuclein
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| Zimbone et al. ACS Chem Neurosci (2024) |
A VEGF Fragment Encompassing Residues 10–30 Inhibits Abeta1–42 Amyloid Aggregation and Exhibits Neuroprotective Properties Matching the Full-Length Protein |
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Alzheimers disease | aggregation | amyloid | neurodegeneration | peptide conformation
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Effects of Charge Sequence Pattern and Lysine-to-Arginine Substitution on the Structural Stability of Bioinspired Polyampholytes |
38567844
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Strategic Single-Residue Substitution in the Antimicrobial Peptide Esc(1–21) Confers Activity against Staphylococcus aureus, Including Drug-Resistant and Biofilm… |
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Staphylococcus aureus | antimicrobial peptides | bent helical structure | biofilm | multidrug-resistant strains | alfa-aminoisobutyric acid
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Inhibition of AuroraA/NMyc Protein–Protein Interaction Using Peptidomimetics: Understanding the Role of Peptide Cyclization |
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Aurora-A kinase | N-Myc | constrained peptides | protein-protein interactions
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Reference Data Set for Circular Dichroism Spectroscopy Comprised of Validated Intrinsically Disordered Protein Models |
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CD | CD prediction | Intrinsically disordered proteins | circular dichroism spectroscopy | protein ensemble refinement | reference data set | secondary structure estimation
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Lanmodulins EF 2–3 Domain: Insights from Infrared Spectroscopy and Simulations |
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Translocation of Antimicrobial Peptides across Model Membranes: The Role of Peptide Chain Length |
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antifungal | antimicrobial | cushion formation | histatin 5 | lipid bilayers | model membrane | peptide | saliva
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Non-fibril amyloid aggregation at the air/water interface: self-adaptive pathway resulting in a 2D Janus nanofilm |
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Structure of Human Serum Albumin at a Foam Surface |
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air-water interface | foam | hydrogen/deuterium exchange mass spectrometry | protein structure
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Leu-Enkephalin Lipid Prodrug Nanoparticles: Relationship between Nanoparticles Structure, Interaction with Bovine Serum Albumin, and Analgesic Activity |
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Impact of Excipient Extraction and Buffer Exchange on Recombinant Monoclonal Antibody Stability |
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biosimilar | buffer exchange | excipients | extraction | higher order structure | monoclonal antibodies
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Amyloids, amorphous aggregates and assemblies of peptides–Assessing aggregation |
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Interfacial Interactions between Nanoplastics and Biological Systems: toward an Atomic and Molecular Understanding of Plastics-Driven Biological Dyshomeostasis |
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ligand-binding | locomotion | microplastics | modeling | nanoplastics | neurons | proteins | structure
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Flexible structural arrangement and DNA-binding properties of protein p6 from Bacillus subtillis phage 29 |
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Novel beta-Hairpin Antimicrobial Peptide Containing the beta-Turn Sequence of-NG-and the Tryptophan Zippers Facilitate Self-Assembly into Nanofibers, Exhibiting… |
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Dual-Targeting EGCG/NO-Supplying protein assembled nanoparticles with Multi-Synergistic effects against atherosclerosis |
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Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl-1 |
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Unlocking the potential of protein-derived peptides to target G-quadruplex DNA: from recognition to anticancer activity |
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Cholesterol conjugated elastin-like recombinamers: Molecular dynamics simulations, conformational changes, and bioactivity |
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GROMACS computer simulations | cholesterol | elastin-like recombinamers | self-assembly | stimuli-responsive biomaterials
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Homeopathic formulations of Syzygium jambolanum alleviate glycation-mediated structural and functional modifications of albumin: evaluation through multi… |
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AsIII Selectively Induces a Disorder-to-Order Transition in the Metalloid Binding Region of the AfArsR Protein |
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Surface chemistry induced igg unfolding and modulation of immune responses |
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biomaterials | immunoglobulin | inflammation | plasma polymerization | surface chemistry
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Accelerated Engineering of ELP-Based Materials through Hybrid Biomimetic-De Novo Predictive Molecular Design. |
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computational modeling | de novo design | machine learning | protein engineering | αhelical conformation
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Cation Triggered Self-Assembly of alfa-Lactalbumin Nanotubes. |
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metal ions | self-assembly | supramolecular metallogels | alfa-lactalbumin nanotubes
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Molecular basis for curvature formation in SepF polymerization. |
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cell division | curvature | interface | self-assembly | solid-state NMR
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Phospholipid-induced secondary structural changes of lysozyme polymorphic amyloid fibrils studied using vacuum-ultraviolet circular dichroism. |
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The limits of prediction: Why intrinsically disordered regions challenge our understanding of antimicrobial peptides. |
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Antimicrobial peptide | Disordered proteins | Peptide design | Prediction
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Site-selective peptide bond hydrolysis and ligation in water by short peptide-based assemblies. |
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amyloid | catalysis | peptide hydrolysis | peptide ligation | reaction networks
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Light-activated molecular purification (LAMP) of recombinant proteins |
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Fluorescence | Light | Organic Polymers | Peptides And Proteins | Purification
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Supramolecular Assembly in Live Cells Mapped by Real-Time Phasor-Fluorescence Lifetime Imaging |
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Cluster Chemistry | Fluorescence | Nanofibers | Peptides And Proteins | Supramolecular Structures And Assemblies
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Molecular Insights into Sequence-Specific Protein Hydrolysis by a Soluble Zirconium-Oxo Cluster Catalyst |
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Cluster Chemistry | Hydrolysis | Ligands | Organic Compounds | Peptides And Proteins
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| Tang et al. Food Chem (2024) |
Effect of temperature on structural configuration and immunoreactivity of pH-stressed soybean (Glycine max) agglutinin |
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Hemagglutinating activity | Immunoreactivity | Soybean agglutinin | Structural configuration | Temperature | pH-stressed
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Design of Chiral betaDouble Helices from Peptide Foldamers |
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Chirality | Double Helix | Foldamers | Peptides | -Amino Acids
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| Geens et al. Protein Sci (2024) |
Biophysical characterization of the Plasmodium falciparum circumsporozoite proteins N-terminal domain |
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Plasmodium falciparum | biophysics | circumsporozoite protein | intrinsic disorder | recombinant protein production and purification | structural biology
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| Ouyang et al. Chinese Journal of Catalysis (2024) |
Artificial metalloenzymes enabled by combining proteins with hemin via protein refolding |
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Artificial metalloenzyme | Click reaction | Hemin | Protein denaturation | Protein refolding
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| Tang et al. ACS Nano (2024) |
Fibroblast Growth Factor Receptor 1-Specific Dehydrogelation to Release Its Inhibitor for Enhanced Lung Tumor Therapy |
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FGFR1 | hydrogel | kinase inhibitor | sustained release | tumor therapy
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| Islam et al. J Proteome Res (2024) |
H-NOX Influences Biofilm Formation, Central Metabolism, and Quorum Sensing in Paracoccus denitrificans |
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Biofilm | cyclic-di-GMP | pyruvate | quorum sensing
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| Zhao et al. ACS Chem Biol (2024) |
De Novo Synthesis and Structural Elucidation of CDR-H3 Loop Mimics |
38916527
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Biopolymers | Chemical Structure | Immunology | Noncovalent Interactions | Peptides And Proteins
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| Camargo et al. ACS Chem Neurosci (2024) |
A Snake Venom Peptide and Its Derivatives Prevent Abeta42 Aggregation and Eliminate Toxic Abeta42 Aggregates In Vitro |
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Abeta42 | aggregation | d-peptide | deaggregation | peptide | snake venom
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| Vignesh et al. Int J Biol Macromol (2024) |
Lutein, a carotenoid found in numerous plants and the human eye, demonstrates the capacity to bundle collagen fibrils |
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Collagen | Fibril | Lutein | Self-assembly | Triple helix
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Different influences of dietary fiber from various sources on the in vitro digestibility of casein as uncovered by the study of protein-dietary fiber interactions |
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Casein | Cellulose | In vitro | Lignin | Pectin | Protein-dietary fiber interactions
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A Novel Bacitracin-like Peptide from Mangrove-Isolated Bacillus paralicheniformis NNS4-3 against MRSA and Its Genomic Insights |
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Bacillus paralicheniformis | MRSA | NNS4-3 | antimicrobial peptide | antimicrobial resistance | bacterial genome | biosynthetic gene cluster | mangrove
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Molecular interactions between gelatin-derived carbon quantum dots and Apo-myoglobin: Implications for carbon nanomaterial frameworks |
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Apo-myoglobin | Carbon quantum dots | Folding/unfolding | Nanotechnology | Protein structure
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| Jusufovic et al. Mol Microbiol (2024) |
Borrelia burgdorferi PlzA is a cyclic-di-GMP dependent DNA and RNA binding protein |
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Borrelia | DNAbinding protein | Lyme disease | cyclicdiGMP
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| Bhopatkar et al. Protein Sci (2024) |
MAPT mutations associated with familial tauopathies lead to formation of conformationally distinct oligomers that have cross-seeding ability |
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MAPT | conformation | crossseeding | frontotemporal dementia | oligomers | tauopathy
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Mapping of the Lipid-Binding Regions of the Antifungal Protein NFAP2 by Exploiting Model Membranes |
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Membranes | Lipids | Peptides And Proteins | Salts | Vesicles
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| Xu et al. Adv Funct Mater (2024) |
Aurora Kinase B-Instruct Release of AZD1152-HQPA from Hydrogel to Enhance Cervical Cancer Suppression |
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-
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| Yang et al. Food Hydrocolloids (2024) |
A sequential fractionation approach to understanding the physicochemical and functional properties of aqueous and enzyme-assisted aqueous extracted black bean proteins |
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Black bean | Osborne fractionation | Enzyme-assisted aqueous extraction | Proteomics | Physicochemical properties | Protein functional properties
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| Learte-Aymamí et al. JACS Au (2024) |
De Novo Engineering of Pd-Metalloproteins and Their Use as Intracellular Catalysts |
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intracellular catalysis | peptide engineering | metallopeptides | grafting | palladium | organometallic catalysis
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| Klawa et al. Nat Commun (2024) |
Uncovering supramolecular chirality codes for the design of tunable biomaterials |
38278785
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Crossref |
-
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| Hsu et al. J Biol Chem (2024) |
Structure, dynamics, and stability of the smallest and most complex 71 protein knot |
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AlphaFold | NMR spectroscopy | X-ray crystallography | artificial intelligence | knotted proteins | mechanical stability | protein folding
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| Alboreggia et al. J Med Chem (2024) |
Covalent Targeting of Histidine Residues with Aryl Fluorosulfates: Application to Mcl-1 BH3 Mimetics |
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An ancestral fold reveals the evolutionary link between RNA polymerase and ribosomal proteins |
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Crossref |
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| Daou et al. Adv Mater (2024) |
Out-of-Equilibrium Mechanical Disruption of beta-Amyloid-Like Fibers using Light-Driven Molecular Motors |
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hydrogels | molecular machines | molecular motors | outofequilibrium systems | responsive materials | betaamyloid structures
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| Maiti et al. Curr Res Struct Biol (2024) |
Experimental methods to study the structure and dynamics of intrinsically disordered regions in proteins |
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Atomic force microscopy (AFM) | Circular dichroism (CD) spectroscopy | Fluorescence spectroscopy | Fourier-transform infrared spectroscopy (FTIR) spectroscopy | NMR spectroscopy | Small angle x-ray scattering (SAXS)
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| Yu et al. Adv Mater (2024) |
Glucose-Triggered Gelation of Supramolecular Peptide Nanocoils with Glucose-Binding Motifs |
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drug delivery | hydrogel | nanotechnology | supramolecular chemistry
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| Eremina et al. Talanta (2024) |
Silver nanoparticle-based SERS sensors for sensitive detection of amyloid-beta aggregates in biological fluids |
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Amyloid-beta | Point-of-care diagnostics | SERS sensor | Silver nanoparticles
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| Luo et al. Adv Mater (2024) |
pH-Responsive beta-Glucans-Complexed mRNA in LNPs as an Oral Vaccine for Enhancing Cancer Immunotherapy |
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cancer immunotherapy | lipid nanoparticle | mRNA vaccine | oral cancer vaccine | betaglucans
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Virus-like particles as powerful vaccination strategy against human viruses |
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challenges | expression systems | human infectious diseases | vaccine | virus | virus-like particles
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Modulation of Alzheimer’s Disease Abeta40 Fibril Polymorphism by the Small Heat Shock Protein alfaB-Crystallin |
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Antarctic yeasts as a source of L-asparaginase: Characterization of a glutaminase-activity free L-asparaginase from psychrotolerant yeast Leucosporidium scottii L115 |
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L-asparaginase | Psychrotolerant yeast | Leucosporidium scottii | Antarctic ecosystems | Cold-adapted yeast | Leukemia
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Proteins released into the plant apoplast by the obligate parasitic protist Albugo selectively repress phyllosphere-associated bacteria |
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antimicrobial proteins | apoplastic proteins | intrinsically disordered proteins | microbe-microbe interactions | microbial community structure | microbiome | phyllosphere microbes | plant pathogen
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Illuminating Intrinsically Disordered Proteins with Integrative Structural Biology |
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flexible | integrative structural biology | intrinsically disordered proteins | protein function | unfolded | unstructured
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The Composition, Structure, and Functionalities of Prolamins from Highland Barley |
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composition | functionalities | highland barley | prolamins | structure
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Novel Covalent Modifier-Induced Local Conformational Changes within the Intrinsically Disordered Region of the Androgen Receptor |
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androgen receptor | covalent drug | intrinsically disordered protein | molecular dynamics simulation | protein conformation
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Characterizing the Interaction of Carmine with Human Serum Albumin Using Biophysical and Molecular Docking Approaches |
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biochemical toxicity | biophysical methods | carmine | human serum albumin | molecular modeling
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Cellular internalization and the spreading of misfolded tau have become increasingly important for elucidating the mechanism of Tau pathology involved in Alzheimer’s disease (AD). The low-density lipoprotein-related receptor 1 (LRP1) has been implica |
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low-density lipoprotein receptor 1 (LRP1); | cellular internalization | molecular dynamics | docking | Tau
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Real-time quaking-induced conversion assay using a small-scale substrate production workflow for the diagnosis of Creutzfeldt-Jakob disease |
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Creutzfeldt-Jakob disease | diagnostic biomarker | low- and middle-income countries | prion disease surveillance | real-time quaking-induced conversion assay
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Biophysical evaluation of the oligomerization and conformational properties of the N-terminal domain of TDP-43 |
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1,8 ANS binding | Circular dichroism | Fluorescence spectroscopy | Molecular dynamics simulation | N-terminal domain of TDP-43 | Oligomerization | Stability | pH
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Selection of synthetic proteins to modulate the human frataxin function |
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conformational stability | iron-sulfur cluster assembly | protein-protein interaction
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Biochemical and structural characterization of the RT domain of Leishmania sp. telomerase reverse transcriptase |
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Leishmania | Protein | Nucleic acid interactions | RT domain | Recombinant protein purification | Structure prediction
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Interaction of plant alkaloid berberine with beta-lactoglobulin: an account from spectroscopic, thermodynamic, and small-angle X-ray scattering studies aided by theoretical calculations |
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Structural, Functional, and Mutational Studies of a Potent Subtilisin Inhibitor from Budgetts Frog, Lepidobatrachus laevis |
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Lipid clearance and amyloid formation by serum amyloid A: exploring the links between beneficial and pathologic actions of an enigmatic protein |
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heparan sulfate mimetic | inflammation and systemic amyloidosis | lipoproteins | cavenger receptor CD36 | secretory phospholipase A2
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Intrinsic Disorder of the Neuronal SNARE Protein SNAP25a in its Pre-fusion Conformation |
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NMR spectroscopy | SNAP25a | SNARE proteins | intrinsically disordered proteins | protein dynamics
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NMR characterization of the structure of the intrinsically disordered region of human origin recognition complex subunit 1, hORC1, and of its interaction with G-quadruplex DNAs |
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DNA replication | G-quadruplex | Intrinsically disordered region | NMR | Origin recognition complex
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Structural and dynamical changes of the Streptococcus gordonii metalloregulatory ScaR protein induced by Mn2+ ion binding |
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Allostery | Metalloregulatory proteins | Transcriptional factor ScaR
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The cationic nature of lysine-rich segments modulates the structural and biochemical properties of wild potato FSK3 dehydrin |
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Abiotic stress | Circular dichroism | Cryoprotection | Dehydrin | K-segment | Lysine residues
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Combined treatment of lactic acid-ultrasound-papain on yak meat and its tenderization mechanism |
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Cutting force | Cutting force | Muscle integrity | Myofibrillar fragmentation index | Myofibrillar protein structure
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Characterization of E121K mutation of D-amino acid oxidase - Insights into mechanisms leading to amyotrophic lateral sclerosis |
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ALS | Aggregation | D-amino acid oxidase mutation | Enzyme activity | FAD
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zinc finger proteins | cadmium | mercury | metal binding affinity | DNA binding | electrospray ionisation mass spectrometry | spectroscopy | EMSA
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Multiresponsive Nanoscale Self-Assembly of Azurin-Elastin-like Polypeptide Fusion Protein for Enhanced Prostate Cancer Therapy |
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Mammalian neurotoxins, Blarina paralytic peptides, cause hyperpolarization of human T-type Ca channel hCav3.2 activation |
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calcium channel | disulfide | gating modifier toxin | mammalian venom | molecular evolution | neurotoxin | peptide chemical synthesis
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N-acetylmuramic acid recognition by MurK kinase from the MurNAc auxotrophic oral pathogen Tannerella forsythia |
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ATPase | MurNAc kinase | bacterial metabolism | cell wall | cell wall recycling | periodontal disease | protein structure.
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Isolation and Characterization of Monomeric Human RAD51: A Novel Tool for Investigating Homologous Recombination in Cancer |
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Supramolecular presentation of bioinstructive peptides on soft multilayered nanobiomaterials stimulates neurite outgrowth† |
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Engineered Recombinant EGFP-Azurin Theranostic Nanosystem for Targeted Therapy of Prostate Cancer |
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EGFP | Eph receptors | azurin | metastasis | nanomedicine | prostate cancer
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Inhibitory to non-inhibitory evolution of the subunit of the F(1)F(O)-ATPase of Paracoccus denitrificans and alfa-proteobacteria as related to mitochondrial endosymbiosis |
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ATP synthase | Paracoccus denitrificans | endosymbiosis | evolution | mitochondria | zeta subunit | alfa-proteobacteria |
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Regulation of IL-24/IL-20R2 complex formation using photocaged tyrosines and UV light |
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cytokines | genetically encoded non-canonical amino acids (ncAA) | interleukin-24 | optobinders | ortho-nitrobenzyltyrosine (NBY) | photocaged proteins | photoxenoprotein engineering | protein-protein interactions (PPI)
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Unraveling the roles of aromatic cluster side-chain interactions on the structural stability and functional significance of psychrophilic Sphingomonas sp. glutaredoxin 3 |
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Structural Characterization and Ligand-Induced Conformational Changes of SenB, a Se-Glycosyltransferase Involved in Selenoneine Biosynthesis |
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Food Antioxidants and Their Interaction with Human Proteins |
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binding | food antioxidants | human proteins | interaction detection
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Hyperstable Synthetic Mini-Proteins as Effective Ligand Scaffolds |
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developability | evolvability | ligand scaffolds | mini-protein | protein engineering
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Rapid Evaluation of Staple Placement in Stabilized alfa Helices Using Bacterial Surface Display |
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Synthesis of robust underwater glues from common proteins via unfolding-aggregating strategy |
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Experimental procedures to investigate fibrillation of proteins |
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Amyloid | Atomic force microscopy | Bovine serum albumin | Circular dichroism | Fibrillation | Study of protein unfolding and aggregation
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Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro |
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Neurodegenerative diseases | TDP-43 | oligomers | aggregation | cytotoxicity | seeding
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Illuminating protein space with a programmable generative model |
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ALS-linked TDP-43 mutations interfere with the recruitment of RNA recognition motifs to G-quadruplex RNA |
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Significant influence of four highly conserved amino-acids in lipochaperon-active sHsps on the structure and functions of the Lo18 protein |
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Phosphatase and Pseudo-Phosphatase Functions of Phosphatase of Regenerating Liver 3 (PRL-3) Are Insensitive to Divalent Metals In Vitro |
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Macromolecular crowding potently stimulates DNA supercoiling activity of Mycobacterium tuberculosis DNA gyrase |
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Mtb DNA gyrase | PEG | PVA | excluded volume | macromolecular crowding | molecular dynamics simulation | water activity
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A TD-DFT Study for the Excited State Calculations of Microhydration of N-Acetyl-Phenylalaninylamide (NAPA) |
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Excited State | H-Bonding | Micro Hydration | Absorption and Fluorescence Energy
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Introduction to the World of Bioinformatics |
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Peptide synthesis | Macromolecule interactions | Hydrogen bonding | BRC analogs
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Bacillus thuringiensis subsp.israelensis | Biophysical characterization | Cry11Aa | LC(50) | Proteolytic cleavage | Purification
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Amorphous aggregates and amyloids | Cytotoxicity | Odorant-binding proteins | Olfactory dysfunction
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Bacterial polyesters | Langmuir-Blodgett | Material binding peptides | Phasins | Pseudomonas putida | Surface functionalization
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Anthocyanin | Bovine lactoferrin | Molecular interaction | Ovotransferrin | pH
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Noscapine | API-IL | Cytotoxicity | Anticancer | Biophysical | Hemoglobin
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Anthocyanins | Proteins | pH value | Binding affinity | Electrostatic interaction
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Cold plasma | Peanut allergen | Ara h 1 | Antigenicity | Quality
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Circular dichroism | Leucine-rich repeat kinase 2 | Parkinsons disease | Phosphorylation | Rab12 | Secondary structure
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GDSx esterases | cold adaptation | enzyme stability | psychrophilic enzymes | temperature adaptation
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Circular dichroism | Fluorescence | Lysozyme amyloidosis | Molecular modeling | Valsartan
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Antibacterial activity | Apoptin | Lipopolysaccharides | Nuclear localization sequence | Peptide homodimer
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Alzheimer’s disease | chaperones | fibril inhibition | protective effect | protein extract
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Electrospinning | Nanofibrous dressing | Regenerative proteins | Serotonin | Third-degree burn | alfa-lactalbumin
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Gram-negative bacteria | Hfq | bacterial amyloid | bacterial communication | cross-kingdom RNA interference | lipid–protein interaction | membrane insertion | outer membrane vesicle (OMV)
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E. coli production of a multi-disulfide bonded SARS-CoV-2 Omicron BA.5 RBD exhibiting native-like biochemical and biophysical properties |
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bacterial-expression system | disulfide bonds | limited proteolysis | receptor binding domain
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Escherichia coli | Omp | Salmonella enterica | amyloid | bacteria | fibril | host–pathogen | outer membrane proteins; porin; virulence.
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X-ray crystallography | bornavirus | negative-strand RNA viruses | phosphoproteins | replication
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covalent chemistry | protein materials | spyCatcher | super-resolution imaging
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Abeta-peptide (Abeta42) | alzheimer’s disease | amyloidosis | amyloids’ degradation | cytotoxicity | superfolder green fluorescent protein (sfGFP)
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insulin | lauryl arginine ethyl ester | nanoemulsion | nasal delivery | permeability enhancement
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Alzheimer’s disease | CD | TEM | ThT | amyloid beta peptide | ovocystatin
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Amyloid fibrils | Circular dichroism | Congo red | Lysozyme | Thioflavin T
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enzymatic hydrolysis | glucose stimulation | transglycosylation activity | beta-glycosidase
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Pisum sativum L.; | amyloid | beta-2-microglobulin | insulin | lysozyme | protein fibril | vicilin | beta-amyloid peptide
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EGCG | bacterial amyloid | green tea | microcin E492 | synchrotron-radiation circular dichroism
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Inside-Out Design of Zinc-Binding Proteins with Non-Native Backbones |
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Repurposing Antimicrobial Protegrin-1 as a Dual-Function Amyloid Inhibitor via Cross-seeding |
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Alzheimer’s disease | amyloid aggregation | amyloid inhibition | cross-seeding | microbial infection | protegrin-1
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charge transport | circular dichroism | molecular electronics | proteins | structure-activity relationships
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Antimicrobial peptide | Calcium ion-binding affinity | Macrolactam ring | Membrane potential | Selectivity index.
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Biological threat agents | Biotoxicology | Biotoxin neutralization | Medical countermeasures | Membrane-toxin interactions | Pore-forming agents
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Dataset for Spectroscopic, Structural and Dynamic Analysis of Human Fe(II)/2OG-Dependent Dioxygenase ALKBH3 |
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CD spectroscopy | fluorescent spectroscopy | dioxygenase | AlkB-like proteins; | ALKBH3 | DNA methylation
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Hydrogen–Deuterium Exchange Vibrational Raman Spectroscopy Distinguishes Distinct Amyloid Polymorphs Comprising Altered Core Architecture |
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alternating copolymer | antibacterial peptides | beta-fold | ornithine | Periodontitis
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CDC48 | CL-MS | NPL4 | UFD1 | crosslinking coupled with MS (XL-MS | integrative modeling | protein quality control | structural mass spectrometry
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aggregation | docking | fluorescence | insulin | sensing
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Advancing Multicomponent Strategies to Macrobicyclic Peptides |
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bicycles | cyclic peptides | macrocyclization | multicomponent reactions | peptides
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Cys mutants as tools to study the oligomerization of the pore-forming toxin sticholysin I |
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Actinoporins | Cys mutants/disulfide bond formation | Oligomerization | Pore-forming protein | Sticholysins
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The 3-(3-oxoisoindolin-1-yl)pentane-2,4-dione (ISOAC1) as a new molecule able to inhibit Amyloid beta aggregation and neurotoxicity |
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Alzheimer’s disease | Amyloid beta 1–42 aggregation | Neuroprotection | beta-diketone-3-substituted isoindolinone
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Effect of green tea extract on heat-induced protein interactions and rennet coagulation in milk |
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Investigation of the Impact of Lipid Acyl Chain Saturation on Fusion Peptide Interactions with Lipid Bilayers |
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fusion peptide | lipid bilayer | neutron spin echo spectroscopy; | small-angle neutron scattering | molecular dynamics simulations
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Subunit association, and thermal and chemical unfolding of Cucurbitaceae phloem exudate lectins. A review |
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Chemical unfolding | Lectins | Protein aggregation | Subunit association | Thermal unfolding
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A class of peptides designed to replicate and enhance the Receptor for Hyaluronic Acid Mediated Motility binding domain |
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Proteolysis-driven proliferation and rigidification of pepsin-resistant amyloid fibrils |
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Amyloid proliferation | Amyloid proliferation | Atomic force microscopy | Pepsin | Proteolysis of amyloid
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Characterization of the common bed bugs eggshell and egg glue proteins |
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Bed bug | Cimex lectularius; | Egg glue protein | Eggshell protein | Repeat protein
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Disordered Domain Shifts the Conformational Ensemble of the Folded Regulatory Domain of the Multidomain Oncoprotein c-Src |
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Divalent metal ion binding to Staphylococcus aureus FeoB transporter regions |
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Copper(II) complexes | FeoB transporter | Metal-peptide complexes | Zinc(II) complexes | iron(II) complexes
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Probing human proteins for short encrypted antimicrobial peptides reveals Hs10, a peptide with selective activity for gram-negative bacteria |
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Antimicrobial peptides | Kamal | Novel antibiotics | Proteome
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Cross-seeding enables repurposing of aurein antimicrobial peptides as a promoter of human islet amyloid polypeptide (hIAPP) |
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Mannose-rich exopolysaccharide from Agaricus sinodeliciosus var. Chaidam: Purification, chemical characterization, and neuroprotective activity |
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A three-state mechanism for trifluoroethanol denaturation of an intrinsically disordered protein (IDP) |
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TFE denaturation of proteins | TFE denaturation of proteins | three-state protein denaturation by TFE | alfa-helical propensity of proteins in aqueous TFE
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A novel lectin from mushroom Phellodon melaleucus displays hemagglutination activity, and antitumor activity in a B16 melanoma mouse model |
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Phellodon melaleucus | Lectin | Hemagglutination activity | Cytokine IL-10 | Antitumor activity
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Rational design of mini protein mimicking uricase: Encapsulation in ZIF-8 for uric acid detection |
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ZIFs | encapsulation | rational design | uric acid | uricase
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Self-Assembled Nanostructures of Homo-Oligopeptide as a Potent Ice Growth Inhibitor |
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antifreeze protein | biomimicry | homo-oligopeptide | nanostructure | ice recrystallization inhibition; | self-assembly
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How Single Site Mutations Can Help Understanding Structure Formation of Amyloid beta1-40 |
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F19L34 contact | amyloid beta140 | oligomers | single site mutation | structure formation
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Chemical synthesis of insulin-like peptide 1 and its potential role in vitellogenesis of the kuruma prawn Marsupenaeus japonicus |
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crustacean | insulin-like peptide | reproduction | solid-phase peptide synthesis | vitellogenesis
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Ts17, a Tityus serrulatus beta-toxin structurally related to alfa-scorpion toxins |
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Beta-toxin | Na(v) | Tityus serrulatus | Toxin | Ts17 | Voltage-gated sodium channels
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Thermal Inactivation Mechanism and Structural Features Providing Enhanced Thermal Stability of Hyperthermophilic Thermococcus sibiricus L-Asparaginase in Comparison with Mesophilic and Thermophilic L-Asparaginases |
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L-asparaginase | Thermococus sibiricus | Rhodospirillum rubrum | Melioribacter roseus | thermostability | CD spectrometry
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Selective modification of tryptophan in polypeptides via C–N coupling with azoles using in situ-generated iodine-based oxidants in aqueous media |
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Crossref |
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Acoustic circular dichroism in a three-dimensional chiral metamaterial |
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Mimotope discovery as a tool to design a vaccine against Zika and dengue viruses |
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Zika | adeno-associated virus | dengue | mimotope | vaccine
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The Prenucleation Equilibrium of the Parathyroid Hormone Determines the Critical Aggregation Concentration and Amyloid Fibril Nucleation |
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biophysics | critical concentration | functional amyloids | nucleation | peptide hormone
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| Hirano et al. Colloids Surf B Biointerfaces (2023) |
Selective and high-capacity binding of immunoglobulin G to zirconia nanoparticles modified with phosphate groups |
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Antibody | Liquid chromatography | Purification | Separation | Zirconia
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| Hachlica et al. Chemistry (2023) |
Chiral and Structural Polymorphism of Fibril Architectures of Homologous Lysozymes |
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amyloid fibril | cryo-EM | polymorphism | lysozyme | supramolecular chirality; | vibrational circular dichroism
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| Park et al. Metallomics (2023) |
Methods for analyzing the coordination and aggregation of metal–amyloid-beta |
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Alzheimers disease | aggregation | amyloid-beta | binding affinity | coordination mode | metal ions
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Enzyme-Mediated Temporal Control over the Conformational Disposition of a Condensed Protein in Macromolecular Crowded Media |
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| Lee et al. Chem Eng J (2023) |
Bioinspired synthesis of micelle-templated ultrathin silica-layered mesoporous nanoparticles with enhanced mass transfer and stability for biocatalysis |
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Influence of Proline Chirality on Neighbouring Azaproline Residue Stereodynamic Nitrogen Preorganization |
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azaproline | chirality | n* interactions | proline editing | beta-turn
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| Garg et al. ACS Food Science & Technology (2023) |
Influence of pH and Heating of Ovalbumin on Interfacial Properties and Rheology of Optimized Volume Fraction Soybean Oil–Water Emulsion Gels |
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ovalbumin | pH | heating | rheology | emulsions | volume fraction
|
| Lal et al. Bioorg Chem (2023) |
beta-Turn editing in Gramicidin S: Activity impact on replacing proline alfa-carbon with stereodynamic nitrogen |
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Antimicrobial peptides | Azaproline | Gramicidin S | MDR S. aureus | Proline editing
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| Grasso et al. Int J Biol Macromo (2023) |
Unveiling the interaction between DNA G-quadruplexes and RG-rich peptides |
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Biophysics | DNA | G-quadruplex | Peptide | RGG motif
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| Li et al. Food Res Int (2023) |
Identification, characterization and in vitro activity of hypoglycemic peptides in whey hydrolysates from rubing cheese by-product |
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Hypoglycemic peptide | LC-MS/MS | Molecular docking | Rubing cheese | Structural characterization | Whey hydrolysates
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| Diedrichsen et al. J Colloid Interface Sci (2023) |
Carrier peptide interactions with liposome membranes induce reversible clustering by surface adsorption and shape deformation |
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Cell-penetrating peptide | Fluorescence lifetime imaging microscopy | Mechanism | Membrane interaction | Small-angle neutron scattering
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| Chen et al. Optica (2023) |
Shaping polarization within an ultrafast laser pulse using dielectric metasurfaces |
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Crossref |
-
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Biochemical interaction of human hemoglobin with ionic liquids of noscapinoids: Spectroscopic and computational approach |
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Hemoglobin | Ionic liquid | Ionic liquid | Noscapine | Spectroscopic analysis
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| Rajasekar et al. Diam Relat Mater. (2023) |
Interaction of BSA with graphene oxide: Influence on the bioactivity of graphene oxide |
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Graphene oxide | Bovine serum albumin | Protein corona | Hemolysis | Cell viability
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Synchrotron radiation circular dichroism spectroscopy reveals that gold and silver nanoparticles modify the secondary structure of a lung surfactant protein B analogue |
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Secondary Structures in Synthetic Poly(Amino Acids): Homo- and Copolymers of Poly(Aib), Poly(Glu), and Poly(Asp) |
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2-aminoisobutyric acid | aspartic acid | glutamic acid | hybrid materials | poly(amino acids) | secondary structures
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| Liu et al. Biochem Pharmacol (2023) |
Isoflavone glucoside genistin, an inhibitor targeting Sortase A and Listeriolysin O, attenuates the virulence of Listeria monocytogenes in vivo and in vitro |
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Antiinfection | Antivirulence | Listeria monocytogenes | Listeriolysin O | Sortase A
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| Gao et al. Inorg Chem (2023) |
Controllable Synthesis of Hemoglobin-Metal Phosphate Organic-Inorganic Hybrid Nanoflowers and Their Applications in Biocatalysis |
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-
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| Wu et al. ACS Appl Mater Interfaces (2023) |
Cancer-Responsive Multifunctional Nanoplatform Based on Peptide Self-Assembly for Highly Efficient Combined Cancer Therapy by Alleviating Hypoxia and Improving the Immunosuppressive Microenvironment |
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MnO2 | immune microenvironment | peptide self-assembly | photodynamic therapy | tumor hypoxia
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Bacterial extracellular electron transfer components are spin selective |
37811828
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-
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| Campagnola et al. J Biol Chem (2023) |
Co-folding and RNA activation of poliovirus 3Cpro polyprotein precursors |
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RNA virus | polyprotein processing | protease | protein folding | protein-RNA interactions
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| Singh et al. Angew Chem Int Ed Engl (2023) |
Exploitation of Catalytic Dyads by Short Peptide-Based Nanotubes for Enantioselective Covalent Catalysis |
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Amyloid | Chiral | Covalent | Enantioselective | Hydrolase
|
| Zhang et al. Int J Biol Macromol (2023) |
Wheat gluten amyloid fibrils: Conditions, mechanism, characterization, application, and future perspectives |
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Amyloid fibrils | Cross-beta structure; | Trypsin | Wheat gluten | “Template” theory
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One-pot preparation of polypeptide nanogels in aqueous solution via ring-opening polymerization-induced nano-gelation |
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| Gao et al. J Mater Chem B (2023) |
Albumin–manganese dioxide nanocomposites: a potent inhibitor and ROS scavenger against Alzheimers beta-amyloid fibrillogenesis and neuroinflammation |
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Crossref |
-
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| Koval et al. Med (2023) |
In-depth molecular profiling of an intronic GNAO1 mutant as the basis for personalized high-throughput drug screening |
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G protein | GNAO1 | Translation to patients | drug discovery | pediatric encephalopathy | personalized medicine | signaling
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| Lin et al. ACS Nano (2023) |
Probing the Protein Folding Energy Landscape: Dissociation of Amyloid-beta Fibrils by Laser-Induced Plasmonic Heating |
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LSPR heating | amyloid-beta fibrils | disassembly | energy landscape | gold nanorods
|
| Yao et al. Sci Total Environ (2023) |
Spectroscopic investigations on the interaction between nano plastic and catalase on molecular level |
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CAT | Enzymatic activity | Nano plastics | Physiological condition | Spectral analysis
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| Ren et al. ACS Appl Mater Interfaces (2023) |
Imine-Linked Covalent Organic Framework Modulates Oxidative Stress in Alzheimers Disease |
36651694
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Alzheimer’s disease | bloodbrain barrier | catalase | covalent organic frameworks | superoxide dismutase
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| Domena et al. J Colloid Interface Sci (2023) |
Advancing glioblastoma imaging: Exploring the potential of organic fluorophore-based red emissive carbon dots |
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Blood brain barrier | Carbon dots | Cell imaging | Glioblastoma | Red emission
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Modulation of Mechanical Properties of Short Bioinspired Peptide Materials by Single Amino-Acid Mutations |
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-
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| Peng et al. ACS Nano (2023) |
Nanocrystals Slow-Releasing Ropivacaine and Doxorubicin to Synergistically Suppress Tumor Recurrence and Relieve Postoperative Pain |
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nanocrystal composite | synergistic antitumor | long-acting analgesia | postoperative pain | tumor recurrence | self-assembling peptide | slow-release
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Bacteria-Responsive Self-Assembly of Antimicrobial Peptide Nanonets for Trap-and-Kill of Antibiotic-Resistant Strains |
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Effects of N-terminal Acetylation on the Aggregation of Disease-related alfa-synuclein Variants |
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Parkinsons disease | alpha-synuclein | oligomers | protein aggregation | secondary nucleation
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| Johnson et al. J Inorg Biochem (2023) |
Second-sphere tuning of analogues for the ferric-hydroperoxoheme form of Mycobacterium tuberculosis MhuD |
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CD spectroscopy | Global fitting | Heme oxygenase | MCD spectroscopy | MhuD | Second-sphere interactions
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Structural Insights into the Ligand-LsrK Kinase Binding Mode: A Step Forward in the Discovery of Novel Antimicrobial Agents |
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| Gielnik et al. Biochemistry (2023) |
Prion Protein Octarepeat Domain Forms Transient beta-Sheet Structures upon Residue-Specific Binding to Cu(II) and Zn(II) Ions |
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-
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| Nguyen et al. Proteoglycan Res (2023) |
Synthesis and optimization of collagen-targeting peptide-glycosaminoglycans for inhibition of platelets following endothelial injury |
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Glycosaminoglycan | collagen | peptide | platelet
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CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology |
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| Fagihi et al. ACS Omega (2023) |
An Investigation into the Acidity-Induced Insulin Agglomeration: Implications for Drug Delivery and Translation |
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Crossref |
-
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| König et al. ACS Nano (2023) |
Stability of Nanopeptides: Structure and Molecular Exchange of Self-assembled Peptide Fibers |
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Peptide-assembly | computer simulation | molecular exchange | nanostructured peptides | peptidepolymer conjugates | small-angle scattering | structural stability
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| Porosk et al. Int J Mol Sci (2023) |
Aggregation Limiting Cell-Penetrating Peptides Derived from Protein Signal Sequences |
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Alzheimer’s disease | aggregation | amyloid beta | cell-penetrating peptides | peptides
|
| Noguchi et al. ACS Appl Mater Interfaces (2023) |
Self-assembled GA-Repeated Peptides as a Biomolecular Scaffold for Biosensing with MoS2 Electrochemical Transistors |
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FET | MoS2 | biosensor | molecular scaffold | peptides | self-assembly
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| Kladova et al. Cells (2023) |
The Activity of Natural Polymorphic Variants of Human DNA Polymerase beta Having an Amino Acid Substitution in the Transferase Domain |
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DNA polymerase beta | DNA repair | enzymatic activity | single-nucleotide polymorphism
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| Rivera et al. Protein Sci (2023) |
Effect of temperature and nucleotide on the binding of BiP chaperone to a protein substrate |
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BiP protein | Grp78 | HSPA5 | heat shock protein | mass photometry | nucleotide-dependent binding | single molecule force spectroscopy | thermo-regulated optical tweezers
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Exploring the Structural Importance of the C3=C4 Double Bond in Plant Alkaloids Harmine and Harmaline on Their Binding Interactions with Hemoglobin |
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Crossref |
-
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| Cao et al. ACS Appl Mater Interfaces (2023) |
Spike Protein Fragments Promote Alzheimers Amyloidogenesis |
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Alzheimer’s disease | SARS-CoV-2 | amyloid beta | spike protein | virus
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| Foo et al. J Agric Food Chem (2023) |
Structure and IgE Cross-Reactivity among Cashew, Pistachio, Walnut, and Peanut Vicilin-Buried Peptides |
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allergen | peanut | tree-nut | vicilin-buried peptide
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Spidroins under the Influence of Alcohol: Effect of Ethanol on Secondary Structure and Molecular Level Solvation of Silk-Like Proteins |
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-
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| Ferková et al. Int J Mol Sci (2023) |
Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System |
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SARS-CoV-2 | circular dichroism (CD) | nuclear magnetic resonance (NMR) | peptidomimetics | protein–protein interaction (PPI)
|
| Nazzaro et al. Angew Chem Int Ed Engl (2023) |
Macrocyclic beta-Sheets Stabilized by Hydrogen Bond Surrogates |
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Constrained Peptides | Macrocycles | Protein Mimics | Protein-Protein-Interactions | beta-Sheets
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The Application of Cinnamon Twig Extract as an Inhibitor of Listeriolysin O against Listeria monocytogenes Infection |
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Listeria monocytogenes | anti-virulence | cinnamon twig extract | infection | inhibitor | listeriolysin O | oligomerization
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Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity |
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Crossref |
-
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Structural properties of the HNF-1A transactivation domain |
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HNF-1A | MODY | diabetes | intrinsically disordered protein | liquid-liquid phase separation | short linear motif | transcription factor | beta-cell
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Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions |
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biophysics | fluorine | molecular assembly | perfluoroalkyl | proteins
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| Gallo et al. Gels (2023) |
Ultrashort Cationic Peptide Fmoc-FFK as Hydrogel Building Block for Potential Biomedical Applications |
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Fmoc-FF analogues | cationic peptide | hydrogels | peptide materials | soft materials
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Following the Fate of Lytic Polysaccharide Monooxygenases under Oxidative Conditions by NMR Spectroscopy |
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Crossref |
-
|
| López-Pérez et al. Protein Sci (2023) |
Ordered-domain unfolding of thermophilic isolated beta subunit ATP synthase |
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circular dichroism | free energy landscape | molecular dynamics | ordered domains | protein unfolding
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| Sciandrone et al. Protein Sci (2023) |
HspB8 interacts with BAG3 in a "native-like" conformation forming a complex that displays chaperone-like activity |
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HspB8-BAG3 complex | autophagy | chaperone-like activity | neurodegenerative diseases | sHsps
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| DUrso et al. Biomolecules (2023) |
Electronic Circular Dichroism Detects Conformational Changes Associated with Proteasome Gating Confirmed Using AFM Imagin |
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(AFM) atomic force microscopy imaging | 20S proteasome; | allostery | cationic porphyrins | electronic circular dichroism (ECD)
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Disease-Associated Mutation A554V Disrupts Normal Autoinhibition of DNMT1 |
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DNA methylation | DNA methyltransferase | epigenetics | neurodegenerative diseases
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Scavenging neurotoxic aldehydes using lysine carbon dots |
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Crossref |
-
|
| Matsuike et al. J Bacteriol (2023) |
Structure and Function of Gli123 Involved in Mycoplasma mobile Gliding |
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conformational change | electron microscopy | lipoprotein | mollicutes | motility | repeat sequence | single-particle analysis | small-angle X-ray scattering
|
| Quareshy et al. FEBS J (2023) |
Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenase CntA catalytic site |
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Rieske monooxygenase | carnitine | cw-EPR | cysteine residues | electron transfer | mononuclear Fe
|
| Kong et al. Adv Sci (Weinh) (2023) |
Extracellular Matrix/Glycopeptide Hybrid Hydrogel as an Immunomodulatory Niche for Endogenous Cardiac Repair after Myocardial Infarction |
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extracellular matrix | glycopeptide | hydrogel | macrophages polarization | tissue regeneration
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Cascade autohydrolysis of Alzheimers Abeta peptides |
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Crossref |
-
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Tidying up the conformational ensemble of a disordered peptide by computational prediction of spectroscopic fingerprints |
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-
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Hydrogel Delivery Device for the In Vitro and In Vivo Sustained Release of Active rhGALNS Enzyme |
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GALNS | Morquio A | drug delivery | polyethylene glycol hydrogel | sustained release
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Therapeutic phosphorodiamidate morpholino oligonucleotides: Physical properties, solution structures, and folding thermodynamics |
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MD simulations | Oligonucleotides | Therapies and Applications | circular dichroism | computational molecular modeling | ensemble of solution structures | phosphorodiamidate morpholino oligomers | viscosity versus concentration profiles
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Interaction of a Histidine-Rich Antimicrobial Saliva Peptide with Model Cell Membranes: The Role of Histidines |
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-
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Structural studies of protein-nucleic acid complexes: A brief overview of the selected techniques |
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Atomic force microscopy (AFM) | Circular Dichroism (DC) | Cryogenic Electron Microscopy (cryo-EM); | Crystallography | DNA-protein interactions | Infrared Scpectroscopy (IR); | Nuclear Magnetic Resonance (NMR) | Nucleic acid binding proteins
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DichroIDP: a method for analyses of intrinsically disordered proteins using circular dichroism spectroscopy |
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| Jelić Matošević et al. Int J Mol Sci (2023) |
Structural Dynamics of the Bacillus subtilis MntR Transcription Factor Is Locked by Mn2+ Binding |
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MntR transcription factor | manganese metallosensors | molecular dynamics simulations | protein structural dynamics
|
| Schwidetzky et al. Proc Natl Acad Sci U S A (2023) |
Functional aggregation of cell-free proteins enables fungal ice nucleation |
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fungi | heterogeneous ice nucleation | ice-nucleating proteins | protein assembly
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Detection and analysis of chiral molecules as disease biomarkers |
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Crossref |
-
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Modulation of the Fibrillation Kinetics and Morphology of a Therapeutic Peptide by Cucurbit[7]uril |
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amyloid | cucurbit[7]uril | enfuvirtide | fibrillation | kinetics
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| Xue et al. Nat Commun (2023) |
Strong, tough, rapid-recovery, and fatigue-resistant hydrogels made of picot peptide fibres |
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-
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Encapsulation of Iron-Saturated Lactoferrin for Proteolysis Protection with Preserving Iron Coordination and Sustained Release |
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lactoferrin | microparticles | protein delivery | protein encapsulation
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High-Value Bioconversion of Ginseng Extracts in Betaine-Based Deep Eutectic Solvents for the Preparation of Deglycosylated Ginsenosides |
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aqueous two-phase system; | biocatalysis | characterization | deep eutectic solvents | deglycosylated ginsenosides
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| Nguyen et al. Appl Environ Microbiol (2023) |
C-Terminal beta8-alfa9 Interaction Modulates Thermal Stability and Enzymatic Activity Differently in Hyperthermophilic Esterase EstE1 and Mesophilic Esterase rPPE |
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dimer interface; | esterase | hydrogen bonds | hydrophobic interactions | temperature adaptation | alfa/beta-hydrolases
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Interaction of Blenoxane and Congeners Bleomycins A2 and B2 with Human Plasma Proteins Using Circular Dichroism Spectroscopy |
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acid glycoprotein; | binding affinity | bleomycin | pharmacokinetic | plasma proteins | protein complex stability | serum albumin
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| Zhong et al. Foods (2023) |
Preparation, Structural Characterization, and Stability of Low-Molecular-Weight Collagen Peptides-Calcium Chelate Derived from Tuna Bones |
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morphological properties | peptides–calcium chelate | stability | structural characterization | tuna bone collagen peptides
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| Monschein et al. Appl Environ Microbiol (2023) |
Loosenin-Like Proteins from Phanerochaete carnosa Impact Both Cellulose and Chitin Fiber Networks |
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Phanerochaete carnosa | biotechnology | carbohydrate active enzymes | carbohydrate binding | cellulose | chitin | expansin | filamentous fungi
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Enhancing the Conformational Stability of the cl-Par-4 Tumor Suppressor via Site-Directed Mutagenesis |
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circular dichroism (CD) spectroscopy | dynamic light scattering (DLS) | intrinsically disordered proteins (IDPs) | nuclear magnetic resonance (NMR) spectroscop | prostate apoptosis response-4 (Par-4) | site-directed mutagenesis | tumor suppressor
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beta-Bracelets: Macrocyclic Cross-beta Epitope Mimics Based on a Tau Conformational Strain |
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Biophysical evolution of the receptor-binding domains of SARS-CoVs |
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New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function |
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arthritis | rheumatoid | autoimmune diseases | autoimmunity | inflammation
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| Tan et al. Molecules (2023) |
Protein-Templated Metal Nanoclusters: Molecular-like Hybrids for Biosensing, Diagnostics and Pharmaceutics |
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bioimaging | biosensors | core-shell structure; | luminescence | metal nanoclusters | nanohybrids | protein-templating synthesis | therapeutics
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Acetylation regulates the oligomerization state and activity of RNase J, the Helicobacter pylori major ribonuclease |
38057323
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-
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| Chuang et al. Protein Sci (2023) |
Investigating the inhibitory property of DM hCT on hCT fibrillization via its relevant peptide fragments |
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amyloid formation | human calcitonin | mutations | osteoporosis | peptide-based inhibitors
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Transcriptome analysis of Corvus splendens reveals a repertoire of antimicrobial peptides |
37907616
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| Kato et al. J Am Chem Soc (2023) |
Evolutionary Engineering of a Cp*Rh(III) Complex-Linked Artificial Metalloenzyme with a Chimeric beta-Barrel Protein Scaffold |
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Construction and Validation of a New Nave Sequestrin Library for Directed Evolution of Binders against Aggregation-Prone Peptides |
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Alzheimer’s disease | Abeta | affibody | directed evolution | phage display | sequestrins
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| Oliveira et al. Molecules (2023) |
Coordination of the N-Terminal Heme in the Non-Classical Peroxidase from Escherichia coli |
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bacterial peroxidase | c-type heme | circular dichroism | heme-peroxidases | non-classical peroxidase | spectroscopic characterization | thermostability | tri-hemic enzyme
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| Li et al. Sci Adv (2023) |
Transformable nano-antibiotics for mechanotherapy and immune activation against drug-resistant Gram-negative bacteria |
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Myofilament-associated proteins with intrinsic disorder (MAPIDs) and their resolution by computational modeling |
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cardiomyopathy | computational modeling | intrinsically disordered protein | myofilament | structure and dynamics
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| Chinnathambi et al. RSC Adv (2023) |
Nano-bio interaction between human immunoglobulin G and nontoxic, near-infrared emitting water-borne silicon quantum dot micelles |
36814879
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-
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| Amin et al. Int J Mol Sci (2023) |
In Vivo and In Vitro Characterization of the RNA Binding Capacity of SETD1A (KMT2F) |
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KMT2F | RNA binding | RNA immunoprecipitation | RRM domain | SETD1A | histone lysine methyltransferase | microscale thermophoresis | non-coding RNA
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Injectable sustained-release poly(lactic-co-glycolic acid) (PLGA) microspheres of exenatide prepared by supercritical fluid extraction of emulsion process based on a design of experiment approach |
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Box–Behnken design | PLGA microspheres | exenatide | pharmacodynamic | pharmacokinetic | supercritical fluid extraction of emulsions | sustainedrelease
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| Sviridov et al. Front Cardiovasc Med (2023) |
Short hydrocarbon stapled ApoC2-mimetic peptides activate lipoprotein lipase and lower plasma triglycerides in mice |
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APOC2 | hydrocarbon staples | hypertriglyceridemia | lipoprotein lipase | peptides
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| Martinez et al. Nat Microbiol (2023) |
Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation |
37679597
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-
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| Wang et al. Protein Sci (2023) |
Trifluoroethanol and the behavior of a tardigrade desiccation-tolerance protein |
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aggregation | desiccation tolerance | disorder | infrared spectroscopy | phase separation | tardigrades | trifluoroethanol
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| Nafaee et al. Protein Sci (2023) |
Revisiting the hydrolysis of ampicillin catalyzed by Temoneira-1 beta-lactamase, and the effect of Ni(II), Cd(II) and Hg(II) |
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199mHg perturbed angular correlation spectroscopy of -rays | TEM-1 beta-lactamase | circular dichroism; | mass spectrometry | reaction kinetics | toxic metal binding
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| Zhang et al. RSC Adv (2023) |
Solution behavior and encapsulation properties of fatty acid-elastin-like polypeptide conjugates |
36712617
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-
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| Radhakrishnan et al. Front Cell Dev Biol (2023) |
Mapping of the extracellular RBP4 ligand binding domain on the RBPR2 receptor for Vitamin A transport |
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RBP4 | Rbpr2 | STRA6 | all-trans retinol | vitamin A
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| Martín Prieto et al. MicroPubl Biol (2023) |
A time-efficient workflow to purify a library of alanine mutants of surface-exposed residues of the domain III of the envelope protein of dengue virus serotype 1 |
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| He et al. Eur Biophys J (2023) |
Coupled folding-upon-binding of human tumor suppressor MIG6 to lung cancer EGFR kinase domain and molecular trimming/stapling of MIG6-derived beta-hairpins to target the coupling event |
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Coupled folding-upon-binding | Epidermal growth factor receptor | Lung cancer | Molecular design; | Peptide | Stapling | Trimming | beta-Hairpin
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| Monti et al. Mol Biotechnol (2023) |
Expression, Purification, Structural and Functional Characterization of Recombinant Human Parvulin 17 |
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Circular Dichroism spectroscopy | FRET-based peptidyl-prolyl cis–trans isomerase assay | High Throughput Screening (HTS) | Par17; | Parvulins | Pin1 | Size-Exclusion Chromatography.
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Biochemical Characterization of the Copper Nitrite Reductase from Neisseria gonorrhoeae |
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AniA | Neisseria | T1 copper center | T2 copper center | copper enzyme | copper nitrite reductase | hyperthermostable | nitrite reduction
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Combining Biophysical Methods for Structure-Function Analyses of RNA in Solution |
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Atomic force microscopy | Isothermal titration calorimetry | RNA structure and dynamics | Riboswitch | Small-angle x-ray scattering
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| Tang et al. ACS Chem Neurosci (2023) |
Atrial Natriuretic Peptide Associated with Cardiovascular Diseases Inhibits Amyloid-beta Aggregation via Cross-Seeding |
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Alzheimer’s disease; | amyloid peptides | atrial natriuretic peptid | cardiovascular dysfunctions | cross-seeding | cross-seeding
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| Handali et al. ACS Appl Bio Mater (2023) |
Gold Nanoparticles Are an Immobilization Platform for Active and Stable Acetylcholinesterase: Demonstration of a General Surface Protein Functionalization Strategy |
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acetylcholinesterase | activity retention | gold nanoparticle functionalization | protein immobilization | protein quantification | protein structure
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Deciphering Structure-Function Relationship Unveils Salt-Resistant Mode of Action of a Potent MRSA-Inhibiting Antimicrobial Peptide, RR14 |
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DPC micelle | antimicrobial peptides | calcein leakage assay | circular dichroism; | membrane permeabilization | nuclear magnetic resonance | paramagnetic relaxation enhancement | solution structure
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| Marchenkov et al. Life (Basel) (2022) |
Recombinant Globular Domain of TcpA Pilin from Vibrio cholerae El Tor: Recovery from Inclusion Bodies and Structural Characterization |
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Vibrio cholerae pilin | inclusion bodies; | protein purification | protein refolding | protein thermodynamics
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| Porter et al. Nat Commun (2022) |
Many dissimilar NusG protein domains switch between alfa-helix and beta-sheet folds |
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-
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| Xu et al. Foods (2022) |
Inactivation of Soybean Trypsin Inhibitor by Dielectric-Barrier Discharge Plasma and Its Safety Evaluation and Application |
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caco-2 cell viability | dielectric-barrier discharge plasma | inactivation | physicochemical properties | rheological properties | safety evaluation | soybean trypsin inhibitor | soymilk quality
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Approaches for evaluation of novel CPP-based cargo delivery systems |
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cargo delivery | cell-penetrating peptides | evaluation approaches | nucleic acid therapeutics | transfection
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| Leyder et al. Int J Mol Sci (2022) |
Unveiling the Metal-Dependent Aggregation Properties of the C-terminal Region of Amyloidogenic Intrinsically Disordered Protein Isoforms DPF3b and DPF3a |
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aggregation | amyloid fibrillation | deep-blue autofluorescence | double-PHD fingers 3 (DPF3) | electron microscopy | intrinsically disordered protein | metal cations | neurodegenerative diseases
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Disulfide Bonds Play a Critical Role in the Structure and Function of the Receptor-binding Domain of the SARS-CoV-2 Spike Antigen |
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RBD | SARS-CoV-2 | disulfide bond | disulfide-reducing agent | receptor-binding domain
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| Meesaragandla et al. ACS Appl Bio Mater (2022) |
Inhibitory Effect of Epigallocatechin Gallate-Silver Nanoparticles and Their Lysozyme Bioconjugates on Biofilm Formation and Cytotoxicity |
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AgNPs | EGCG | antibacterial activity | biofilms | conformational change | human lysozyme
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High-Level Expression of Palmitoylated MPP1 Recombinant Protein in Mammalian Cells |
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Designing and characterization of a SARS-CoV-2 immunogen with receptor binding motif grafted on a protein scaffold: An epitope-focused vaccine approach |
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Immuno-focusing | RBD | SARS-CoV-2 | Scaffold | Vaccine
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Evaluation of the Antimicrobial Properties of a Natural Peptide from Vespa mandarinia Venom and Its Synthetic Analogues as a Possible Route to Defeat Drug-Resistant Microbes |
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Galleria mellonella larva model | antimicrobial peptides | peptide modification | wasp venom
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| Shi et al. ACS Omega (2022) |
N-terminal Domain of Amyloid-beta Impacts Fibrillation and Neurotoxicity |
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Effect of ultrasonic cavitation on the formation of soy protein isolate - rice starch complexes, and the characterization and prediction of interaction sites using molecular techniques |
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Molecular docking | Protein-carbohydrate complex | Rice starch | Soy protein isolate | Ultrasound
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The ataxia-linked E1081Q mutation affects the sub-plasma membrane Ca2+-microdomains by tuning PMCA3 activity |
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| Najarzadeh et al. BBA Adv (2022) |
Interaction of membrane vesicles with the Pseudomonas functional amyloid protein FapC facilitates amyloid formation |
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EGCG | FapC protein | ThT kinetics | bacterial amyloid | membrane vesicle
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| Chun et al. Chem Sci (2022) |
Direct observation of protein structural transitions through entire amyloid aggregation processes in water using 2D-IR spectroscopy |
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-
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| Brindha et al. Int J Mol Sci (2022) |
A Multi-Disulfide Receptor-Binding Domain (RBD) of the SARS-CoV-2 Spike Protein Expressed in E. coli Using a SEP-Tag Produces Antisera Interacting with the Mammalian Cell Expressed Spike (S1) Protein |
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Escherichia coli expression | disulfide bond | fusion tag | immunogenicity | solubility
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| Mameri et al. Sci Rep (2022) |
Critical structural elements for the antigenicity of wheat allergen LTP1 (Tri a 14) revealed by site-directed mutagenesis |
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| Murray et al. Proc Natl Acad Sci U S A (2022) |
De novo designed protein inhibitors of amyloid aggregation and seeding |
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alpha-synuclein | amyloid | amyloid-beta | protein design | tau
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Recombinant expression and antigenicity of two peptide families of neurotoxins from Androctonus sp |
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Androctonus | Antibodies | Protein expression | Scorpion venom
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| Patrick et al. J Mol Biol (2022) |
Biophysical Fitness Landscape of the SARS-CoV-2 Delta Variant Receptor Binding Domain |
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Protein stability | immune escape | neutralizing antibodies | protein expression | receptor binding
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| Lakshmanan et al. Viruses (2022) |
Structural Dynamics and Activity of B19V VP1u during the pHs of Cell Entry and Endosomal Trafficking |
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B19V | CD spectroscopy | MVM | PLA2 | VP1u | endosomal trafficking; | minute virus of mice | parvovirus B19
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| Yan et al. Front Nutr (2022) |
Modification of Ovalbumin by Maillard Reaction: Effect of Heating Temperature and Different Monosaccharides |
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Maillard reaction | emulsifying properties | ovalbumin | protein structure | reaction temperature
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| Wibowo et al. Int J Mol Sci (2022) |
Quantification and Improvement of the Dynamics of Human Serum Albumin and Glycated Human Serum Albumin with Astaxanthin/Astaxanthin-Metal Ion Complexes: Physico-Chemical and Computational Approaches |
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antioxidants | astaxanthin | astaxanthin metal complexes | diabetes mellitus type 2 | glycated human serum albumin | human serum albumin | multi-techniques and computational analysis
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| Zhao et al. Bioresour Bioprocess (2022) |
Dissecting the essential role of N-glycosylation in catalytic performance of xanthan lyase |
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Catalytic properties | N-Glycosylation | Site-directed mutagenesis | Structure regulation | Xanthan lyase
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| Beniamino et al. Biomolecules (2022) |
The Ni(II)-Binding Activity of the Intrinsically Disordered Region of Human NDRG1, a Protein Involved in Cancer Development |
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circular dichroism | intrinsically disordered regions | isothermal titration calorimetry | light scattering | lung cancer | nickel | nmr
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| Kosolapova et al. Front Plant Sci (2022) |
RopB protein of Rhizobium leguminosarum bv. viciae adopts amyloid state during symbiotic interactions with pea (Pisum sativum L.) |
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Pisum sativum L. | RopB | amyloid | beta-barrel; | nodule | outer membrane protein | plant-microbe interactions | symbiosis
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| Kim et al. Int J Mol Sci (2022) |
Identification of Bacterial Membrane Selectivity of Romo1-Derived Antimicrobial Peptide AMPR-22 via Molecular Dynamics |
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AMPR-22 | antimicrobial peptide | bacterial membrane selectivity | extensively drug-resistant bacteria | molecular dynamics.
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| Brindha et al. Int J Mol Sci (2022) |
An Escherichia coli Expressed Multi-Disulfide Bonded SARS-CoV-2 RBD Shows Native-like Biophysical Properties and Elicits Neutralizing Antisera in a Mouse Model |
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Escherichia coli expression | cell surface markers | disulfide bond | immunogenicity | oxidative refolding | pseudovirus neutralization | subunit antigen
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| Vergunst et al. Appl Microbiol Biotechnol (2022) |
Characterization of the structure and self-assembly of two distinct class IB hydrophobins |
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Hydrophobin | Nuclear magnetic resonance spectroscopy | Protein structure | Thioflavin T | Rodlet
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Crotoxin B: Heterologous Expression, Protein Folding, Immunogenic Properties, and Irregular Presence in Crotalid Venoms |
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Crotalus tzabcan | antibodies | phospholipase | protein expression | snake | venom | viper
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Molecular characterization of linker and loop-mediated structural modulation and hinge motion in the C4-C5 domains of cMyBPC |
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-
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The Anfinsen Dogma: Intriguing Details Sixty-Five Years Later |
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disulfide | oxidative folding | protein folding | protein structure | ribonuclease
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The proximity of the N- and C- termini of bovine knob domains enable engineering of target specificity into polypeptide chains |
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Bovine antibodies | VHH | bispecific | complement C5 | knob domain | serum albumin
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An Intrinsically Disordered Peptide Tag that Confers an Unusual Solubility to Aggregation-Prone Proteins |
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NEXT tag | PETase | carbonic anhydrase | entropic bristle | intrinsically disordered | soluble expression
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Structure of Lacticaseicin 30 and Its Engineered Variants Revealed an Interplay between the N-Terminal and C-Terminal Regions in the Activity against Gram-Negative Bacteria |
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Escherichia coli | antimicrobial activity | helical conformation | structure-activity relationship
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Plant-specific HDT family histone deacetylases are nucleoplasmins |
36069647
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-
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| Sabour et al. Molecules (2022) |
Insight into the Interaction Mechanism of HSA with Aztreonam: A Multispectroscopic and Computational Approach |
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FRET | HSA | aztreonam | docking | simulation
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Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling |
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PDZ domain | cell polarity | crystallography | isothermal titration calorimetry | virology
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Identification of Phosphorylation and Other Post-Translational Modifications in the Central C4C5 Domains of Murine Cardiac Myosin Binding Protein C |
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Self-assembly and Hydrogelation Properties of Peptides Derived from Peptic Cleavage of Aggregation-prone Regions of Ovalbumin |
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biomechanical properties | egg white hydrolysates | ovalbumin | peptide hydrogels; | peptide self-assembly | rheology
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Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery |
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-
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N-Terminal Acetylation of alfa-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates |
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Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation |
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Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold |
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3CLpro | COVID-19 | D-peptides | SARS-CoV-2 | crotamine derivative peptides | inhibitor | main protease
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A disordered region retains the full protease inhibitor activity and the capacity to induce CD8+ T cells in vivo of the oral vaccine adjuvant U-Omp19 |
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Circular dichroism; | guanidinium chloride | IDP | immobilized metal ion affinity chromatography | maltose binding protein | molecular weight; | NMR | Protease inhibitor
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Characterization of full-length p53 aggregates and their kinetics of formation |
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Conformational Studies of the Par-4 C-Terminal Domain |
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Higher-order structure analysis of high concentration monoclonal antibody by circular dichroism (CD) and infrared (IR) spectroscopy |
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A Toxicologic Review of Quantum Dots: Recent Insights and Future Directions |
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Mucin-Type O-Glycosylation Proximal to beta-Secretase Cleavage Site Affects APP Processing and Aggregation Fate |
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APP O-glycopeptides | Alzheimer’s disease | aggregation kinetics | circular dichroism | proteolysis
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Biophysical properties of human body louse nit related proteins: LNSP1, Agp9 and Agp22 |
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Accessory gland | Human body/head louse | LNSP | Nit | Pediculus humanus
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Reversible, beta-sheet-dependent self-assembly of the phosphoprotein phosvitin is controlled by the concentration and valency of cations |
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Myeloperoxidase-induced fibrinogen unfolding and clotting |
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atomic force microscopy | fibrinogen clotting | protein denaturation | protein materials | scanning electron microscopy | single-molecule analysis
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Synthesis and properties of helical polystyrene derivatives with amino acid side groups |
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Near-infrared irradiation controlled thermo-switchable polymeric photosensitizer against beta-amyloid fibrillation |
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Investigation of biochemical and biotechnological potential of a thermo-halo-alkali-tolerant endo-xylanase (GH11) from Humicola brevis var. thermoidea for lignocellulosic valorization of sugarcane biomass |
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Lignocellulosic biomass | Hemicellulose valorization | Endo-xylanase | Humicola brevis | Sugarcane bagasse hydrolysis
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Analysis of Bacterial Amyloid Interaction with Lipidic Membrane by Orientated Circular Dichroism and Infrared Spectroscopies |
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Coiled-Coil Helical Nano-Assemblies: Shape Persistent, Thixotropic, and Tunable Chiroptical Properties |
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Assembly of Cas7 subunits of Leptospira on the mature crRNA of CRISPR-Cas I-B is modulated by divalent ions |
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CRISPR-Cas type I-B | Cas7 | DNase | Leptospira interrogans; | LinCas7 | RNase
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N-glycosylation modulates enzymatic activity of Trypanosoma congolense trans-sialidase |
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Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics |
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Deciphering cellular and molecular determinants of human DPCD protein in complex with RUVBL1/RUVBL2 AAA-ATPases |
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DPCD | EM | LUMIER-IP | RUVBL1 | RUVBL2 | SAXS | SILAC-IP | structural MS
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NDM-1 Zn1-binding residue His116 plays critical roles in antibiotic hydrolysis |
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New Delhi metallo-beta-lactamase 1 | beta-lactam | Antibiotic resistance | Active site mutation | Enzyme kinetics | Molecular dynamics simulation
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Analysis of Plasmodium falciparum myosin B ATPase activity and structure in complex with the calmodulin-like domain of its light chain MLC-B |
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cell motility | chaperone | kinetics | kinetics | malaria | molecular motor | myosin | protein complex
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| Akbari et al. Int J Biol Macromol (2022) |
Investigation of the role of prolines 232/233 in RTPPK motif in tau protein aggregation: An in vitro study |
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Alzheimers disease | Cis-trans isomerization | Tau aggregation
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Characterizing protein-surface and protein-nanoparticle conjugates: Activity, binding, and structure |
36075725
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Crossref |
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Sequence-Controlled Secondary Structures and Stimuli Responsiveness of Bioinspired Polyampholytes |
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Crossref |
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Salt-Induced Dissolution of Protein Aggregates |
36283072
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Crossref |
-
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| Nakayama et al. ACS Appl Mater Interfaces (2022) |
Proteins Protein Corona: Nanoscale Size Evolution of Human Immunoglobulin G Aggregates Induced by Serum Albumin |
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aggregation | antibody | electrostatic interaction | nanoparticle | protein corona
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| Anada et al. Langmuir (2022) |
Improvement of Thermal Stability of Amphipathic Peptide-Phospholipid Nanodiscs via Lateral Association of alfa-Helices by Disulfide Cross-Linking |
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Type C mutation of nucleophosmin 1 acute myeloid leukemia: Consequences of intrinsic disorder |
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Acute myeloid leukemia | Aggregation | Intrinsically disordered regions; | Wide-Angle X-ray Scattering
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Calcium regulates the interplay between the tight junction and epithelial adherens junction at the plasma membrane |
34882783
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E-cadherin | circular dichroism | claudin | junctional adhesion molecule | surface plasmon resonance
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| Manna et al. Eur J Med Chem (2022) |
Ad-hoc modifications of cyclic mimetics of SOCS1 protein: Structural and functional insights |
36152385
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Cyclic peptides | Cytokine signaling | JAK/STAT | Mimetic peptides | SOCS1
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GLPGPSGEEGKR: Fe2+ chelating characterization and potential transport pathways for improving Fe2+ bioavailability in Caco-2cells |
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Fe2+ chelating peptide | Peptide-G-R-Fe2+ complex | Chelating properties | Bioavailability | Transport mechanism
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Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state |
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PGAM5 | helix dynamics; | intramembrane proteolysis | oligomeric state | rhomboid serine protease
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Relationship between type II polyproline helix secondary structure and thermal hysteresis activity of short homopeptides |
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Antifreeze proteins | Antifreezing | Cationic homopeptides | Differential scanning calorimetry | Homopeptides | Ice-binding proteins | Ice recrystallization | Polyproline II helix
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Pattern enrichment analysis for phage selection of stapled peptide ligands |
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Crossref |
-
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Competitive inhibition of the classical complement pathway using exogenous single-chain C1q recognition proteins |
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CD spectroscopy | complement activation | complement inhibition | hemolysis; | molecular cloning | multimers | neuronal pentraxins | surface plasmon resonance
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| Florio et al. Bioorg Chem (2022) |
Small molecules enhancers of amyloid aggregation of C-terminal domain of Nucleophosmin 1 in acute myeloid leukemia |
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Acute myeloid leukemia | Aggregation | Amyloid fibers | Small molecules
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Circular dichroism of biopharmaceutical proteins in a quality-regulated environment |
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Biopharmaceutical | Circular dichroism | Higher order structure; | Uncertainty of measurement | Validation
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Benzo[d]thiazole-2-Carboxamides As New Antituberculosis Chemotypes Inhibiting Mycobacterial ATP Phosphoribosyl Transferase |
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ATP-PRTase (HisG) inhibition | L-histidine complementation assay | anti-TB drug target | benzo[d]thiazole-2-carboxamides | interaction with secondary structure | molecular docking | molecular dynamics simulation.
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Clustering and cross-linking of the wheat storage protein alfa-gliadin: A combined experimental and theoretical approach |
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Disulphide bonds | Monte Carlo simulations | Polymers | Synthetic peptides
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An amphiphilic small molecule drives insulin aggregation inhibition and amyloid disintegration |
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Chemical chaperone | Disaggregation | Excipient | Inhibitors | Sulfonate
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| Jang et al. ACS Nano (2022) |
Metal-Organic Framework-Derived Carbon as a Photoacoustic Modulator of Alzheimers beta-Amyloid Aggregate Structure |
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amyloid | carbon nanoparticles | metalorganic framework | near-infrared light | photoacoustic.
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Conformation-Stabilized Amorphous Nanocoating for Rational Design of Long-Term Thermostable Viral Vaccines |
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Zn-mIM coordination polymer | amorphous | nanocoating | thermostability | virus
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| Zhang et al. Int J Biol Macromol (2022) |
A glycoprotein from mountain cultivated ginseng: Insights into their chemical characteristics and intracellular antioxidant activity |
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Antioxidant activity | Glycoprotein | Mountain-cultivated ginseng
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Characterization of the Conformations of Amyloid Beta 42 in Solution That May Mediate Its Initial Hydrophobic Aggregation |
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Crossref |
-
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| Wonderly et al. Cell (2022) |
A multi-tasking polypeptide from bloodworm jaws: Catalyst, template, and copolymer in film formation |
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low-complexity protein | melanin | self-assembly | bio-inspired | multi-functional
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Expression, Purification, and Characterisation of South African Cassava Mosaic Virus Cell-to-Cell Movement Protein |
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ANS | South African cassava mosaic virus (SACMV) | cell-to-cell movement protein | xtrinsic ANS fluorescence | intrinsic tryptophan fluorescence | mant-ATP
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Circular Dichroism Spectra of alfa-Chymotrypsin-SDS Solutions Depend on the Procedure of Their Preparation |
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Crossref |
-
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| Moretti et al. Molecules (2022) |
Conversion of the Native N-Terminal Domain of TDP-43 into a Monomeric Alternative Fold with Lower Aggregation Propensity |
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micelle | native-like | neurodegeneration | oligomerisation | self-assembly
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Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes |
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Autoimmunity | Immune response | Insulin | Insulin autoantibodies | Insulin neoepitope peptide | Neoantigen | Neoepitope | Oxidative post-translational modifications
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| Han et al. Nat Chem (2022) |
Conformational and functional changes of the native neuropeptide somatostatin occur in the presence of copper and amyloid-beta |
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| Horváth et al. Int J Mol Sci (2022) |
Multiple Timescale Dynamic Analysis of Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding Protein |
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NMR spectroscopy | bile acids | enterohepatic circulation | intracellular lipid-binding proteins | ligand binding | positive cooperativity | protein dynamics | site-selectivity
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| Sharma et al. RSC Adv (2022) |
Amyloid fibrillation of the glaucoma associated myocilin protein is inhibited by epicatechin gallate (ECG) |
36320765
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| Zhang et al. Biochemistry (2022) |
A Disulfide-Stabilized Abeta that Forms Dimers but Does Not Form Fibrils |
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Biophysical characterization of the recombinant chitinase chi18-5 with potential biotechnological interest |
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Biophysical characterization | Characterization | Chi18-5; | Chitinase | Circular dichroism | Infrared spectroscopy
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| Zhao et al. Commun Biol (2022) |
Artificial intelligence-assisted cryoEM structure of Bfr2-Lcp5 complex observed in the yeast small subunit processome |
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-
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| Chatterjee et al. Biomimetics (Basel) (2022) |
At the Intersection of Natural Structural Coloration and Bioengineering |
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biophotonics | cephalopod | optical materials | protein | structural color
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| Liu et al. Curr Res Food Sci (2022) |
Fabrication of zein-modified starch nanoparticle complexes via microfluidic chip and encapsulation of nisin |
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Encapsulation | Microfluidic chip | Nisin | OSA-Modified starch | Stability | Zein nanoparticle
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Acoustic sorting of microfluidic droplets at kHz rates using optical absorbance |
36472476
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Crossref |
-
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| Shen et al. Biochem Biophys Rep (2022) |
Effects of zinc and carnosine on aggregation kinetics of Amyloid-beta40 peptide |
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B.1.1.7 (Alpha) variant is the most antigenic compared to Wuhan strain, B.1.351, B.1.1.28/triple mutant and B.1.429 variants |
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B.1.1.7 | CD spectra | CTL epitopes | SAg-like region | antigenicity | cluster | emerging variants | phage-displayed peptides
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| Dominguez et al. PLoS One (2022) |
Redefining the architecture of ferlin proteins: Insights into multi-domain protein structure and function |
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Protein domains | Phospholipids | Protein Structure | Proline | Crystal structure | Sequence alignment | cations
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A mutation in the S6 segment of the KvAP channel changes the secondary structure and alters ion channel activity in a lipid bilayer membrane |
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KvAP channel; | S6 segment
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| Rosa et al. Gels (2022) |
Incorporation of PEG Diacrylates (PEGDA) Generates Hybrid Fmoc-FF Hydrogel Matrices |
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Fmoc-FF | PEGDA | biohybrid materials | multicomponent hydrogels | peptide hydrogels | peptide materials | supramolecular assembly
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Bioengineering a glucose oxidase nanosensor for near-infrared continuous glucose monitoring |
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Scalable agroinfiltration-based production of SARS-CoV-2 antigens for use in diagnostic assays and subunit vaccines |
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-
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Kinesin-3 motors are fine-tuned at the molecular level to endow distinct mechanical outputs |
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ATPases | Baculovirus | Chemomechanical | Kinesin-3 | Microtubule bending | Superprocessive
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| Kowalik et al. Biomolecules (2022) |
Dopamine D(2) and Serotonin 5-HT(1A) Dimeric Receptor-Binding Monomeric Antibody scFv as a Potential Ligand for Carrying Drugs Targeting Selected Areas of the Brain |
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D2–5-HT1A heteromer | cytotoxicity | nanogold particles | nanomedicine | nanoparticles | scFv antibody | targeted drug delivery
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Solution characterization of the dynamic conjugative entry exclusion protein TraG |
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Dichroism | Mass spectrometry | X-ray scattering | Bacteria | Proteins | Bioinformatics
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| Baksh et al. J Biol Chem (2022) |
Mechanistic insights into the nickel-dependent allosteric response of the Helicobacter pylori NikR transcription factor |
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DNA-binding protein | DNA-protein interaction | allosteric regulation | bacterial transcription | computational biology | metal homeostasis; | metalloprotein | nickel
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Tonsillar Microbiome-Derived Lantibiotics Induce Structural Changes of IL-6 and IL-21 Receptors and Modulate Host Immunity |
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IL-6 and IL-21 receptor | lantibiotics | rheumatoid arthritis | salivaricins | tonsillar microbiome
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| Itkonen et al. Pharmaceutics (2022) |
Analysis of Biologics Molecular Descriptors towards Predictive Modelling for Protein Drug Development Using Time-Gated Raman Spectroscopy |
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CD | DLS | K-means clustering | PCA | Raman spectroscopy | biologics | in-line measurement | pharmaceutical proteins
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A Surface Exposed, Two-Domain Lipoprotein Cargo of a Type XI Secretion System Promotes Colonization of Host Intestinal Epithelia Expressing Glycans |
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NMR | Slam | lipidation | metabolomics | proteomics | symbiosis | type XI secretion
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| Crawford et al. ACS Infect Dis (2022) |
Disparate Regions of the Human Chemokine CXCL10 Exhibit Broad-Spectrum Antimicrobial Activity against Biodefense and Antibiotic-Resistant Bacterial Pathogens |
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CXCL10 | antibiotic resistant | antimicrobial peptide | bacteria | chemokine | hydrocarbon staple
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The interaction between LC8 and LCA5 reveals a novel oligomerization function of LC8 in the ciliary-centrosome system |
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-
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In Vitro Biophysical Characterization of Candidalysin: A Fungal Peptide Toxin |
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Biophysics | Candida albicans | Candidalysin | Circular dichroism | Electrical recording | Fungal infections | Membrane permeabilization | Peptide
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Rapid restructurization of conformationally-distinct alpha-synuclein amyloid fibrils at an elevated temperature |
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Alpha-synuclein | Amyloid | Fibril structure; | Protein aggregation | Protein fibrils
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Protein sustained release from isobutyramide-grafted stellate mesoporous silica nanoparticles |
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Nanoparticles | Protein quantification | Protein sustained release | Protein-surface interactions | Stellate mesoporous silica.
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Novel Stilbene-Nitroxyl Hybrid Compounds Display Discrete Modulation of Amyloid Beta Toxicity and Structure |
35720993
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Alzheimer’s disease | EPR (electron paramagnetic resonance) | amyloid beta peptide (Abeta) | circular dichroism (CD) | oxidative stress | protein aggregation | protein misfolding
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Evaluation of Amyloid Inhibitor Efficiency to Block Bacterial Survival |
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Antibacterial | Bacterial adaptation; | Bacterial amyloid | Functional amyloid | Hfq | Protein fibrillation inhibition | Protein fibrils
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Databases for intrinsically disordered proteins |
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databases | flexible proteins | intrinsically disordered proteins | protein ensembles
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Insights into Network of Hot Spots of Aggregation in Nucleophosmin 1 |
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ThT fluorescence | aggregation | bioinformatic prediction
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Comparative Study of the Solid-Liquid Interfacial Adsorption of Proteins in Their Native and Amyloid Forms |
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AFM imaging | QCM technique | amyloids | protein adsorption | wettability
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Binding of Glycerol to Human Galectin-7 Expands Stability and Modulates Its Functions |
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aquaporin-3 | crystal structure | galectin-7 | glycerol | stability
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Influence of force field choice on the conformational landscape of rat and human islet amyloid polypeptide |
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intrinsically disordered proteins | islet amyloid polypeptide | metadynamics | secondary structure
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Computational and Experimental Evaluation of the Stability of a GLP-1-like Peptide in Ethanol-Water Mixtures |
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GLP-1 agonist | dimer formation | ethanol | molecular dynamics | peptide | protein–protein interactions | stability
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Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma |
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DH domain | Dbl homology | GEF | PH domain | PIP | RhoA | RhoGEF | glioblastoma
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Thermodynamic analysis of an entropically driven, high-affinity nanobody-HIV p24 interaction |
36527237
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Crossref |
-
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| Oyama et al. Appl Spectrosc (2022) |
Performance Comparison of Spectral Distance Calculation Methods |
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CD | Circular dichroism; | antibody drugs; | biopharmaceutical characterization | biosimilar | protein structures | spectroscopy
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| Minami SA et al. Biotechnol J (2022) |
Production of novel SARS-CoV-2 Spike truncations in Chinese hamster ovary cells leads to high expression and binding to antibodies |
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COVID-19 | Chinese hamster ovary cells | SARS-CoV-2 | Spike | antibody binding
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Reverse Engineering Analysis of the High-Temperature Reversible Oligomerization and Amyloidogenicity of PSD95-PDZ3 |
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amyloidogenicity | high-temperature reversible oligomerization | mutational analysis | oligomeric interface residues | thermal denaturation
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Binding and Kinetic Analysis of Human Protein Phosphatase PP2A Interactions with Caspase 9 Protein and the Interfering Peptide C9h |
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Crossref |
-
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A native IgE in complex with profilin provides insights into allergen recognition and cross-reactivity |
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| Aggrawal et al. RSC Adv (2022) |
Refolding of denatured gold nanoparticles-conjugated bovine serum albumin through formation of catanions between gemini surfactant and sodium dodecyl sulphate |
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-
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Drunken lipid membranes, not drunken SNARE proteins, promote fusion in a model of neurotransmitter release |
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FLIC | SNARE proteins | TIRT | electrophysiology | ethanol | membrane fusion | circular dichroism
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Exploring Glycan Binding Specificity of Odorranalectin by Alanine Scanning Library |
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Alanine scanning | Cyclic peptides | Fluorescent probes | Glycan binding | Thermodynamics
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Secondary Structure Characterization of Glucagon Products by Circular Dichroism and Nuclear Magnetic Resonance Spectroscopy |
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2D NOESY | CD | NMR | alpha helix | glucagon | secondary structure | spectroscopy | synthetic peptide
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| Marchenkov et al. Molecules (2022) |
The Denaturant- and Mutation-Induced Disassembly of Pseudomonas aeruginosa Hexameric Hfq Y55W Mutant |
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Hfq hexamer | fluorescence | mutations | thermodynamics | unfolding intermediates
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Anti-Metalloprotease P-I Single-Domain Antibodies: Tools for Next-Generation Snakebite Antivenoms |
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Crossref |
-
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| Bryan et al. ACS Omega (2022) |
Site-Specific C-Terminal Fluorescent Labeling of Tau Protein |
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Aggregation | Flourescence | Labeling | Nanofibres | Peptides and Proteins
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Molecular dynamics simulations of the adsorption of an intrinsically disordered protein: Force field and water model evaluation in comparison with experiments |
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adsorption | conformational ensemble | force field (FF) | intrinsically disordered proteins (IDPs) | molecular dynamics | water models
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Phosphorylation of covalent organic framework nanospheres for inhibition of amyloid-beta peptide fibrillation |
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Crossref |
-
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| Kawagoe et al. Biochemistry (2022) |
Heat-Induced Conformational Transition Mechanism of Heat Shock Factor 1 Investigated by Tryptophan Probe |
36485006
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Crossref |
-
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| Tang et al. Commun Biol (2022) |
Cross-seeding between Abeta and SEVI indicates a pathogenic link and gender difference between alzheimer diseases and AIDS |
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Crossref |
-
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Biomolecular Complexation on the "Wrong Side": A Case Study of the Influence of Salts and Sugars on the Interactions between Bovine Serum Albumin and Sodium Polystyrene Sulfonate |
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Carbohydrates | complexation | Ionic strength | Salts | Titration
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Impact of aromatic residues on the intrinsic disorder and transitional behaviour of model IDPs |
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Elastin | Intrinsically disordered proteins | Protein block co-polymers | Self-assembling materials
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| Islam et al. ACS Chem Neurosci (2022) |
Effects of Charged Polyelectrolytes on Amyloid Fibril Formation of a Tau Fragment |
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aggregation | chitosan | electrostatic interaction | heparin | polyelectrolytes | tau
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Electronic Structure and Solvation Effects from Core and Valence Photoelectron Spectroscopy of Serum Albumin |
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X-ray electron spectroscop | electronic structure | hydration | protein | theoretical chemistry
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Formation of beta-Strand Oligomers of Antimicrobial Peptide Magainin 2 Contributes to Disruption of Phospholipid Membrane |
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amyloid | antimicrobial peptide | flourescence anisotropy | linear dichroism | magainin 2 | peptide-membrane interaction | synchrotron-radiation circular dichroism | beta-strand oligomers
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Structural and biochemical analysis reveals how ferulic acid improves catalytic efficiency of Humicola grisea xylanase |
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Crossref |
-
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| Cheng et al. Curr Pharm Des (2022) |
Hydrophobic-hydrophilic Alternation: An effective Pattern to de novo Designed Antimicrobial Peptides |
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Novel antimicrobial agent, | functional pattern | engineered peptide | cationic amphiphiles | membrane destroyer, | amphiphilic interface, | antimicrobial mechanism
|
| Wollborn et al. J Colloid Interface Sci (2022) |
Protein conformational changes at the oil/water-interface induced by premix membrane emulsification |
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Circular dichroism | Membrane emulsification | Molecular dynamics | Oil/Water interface | Protein
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Mechanistic insights into accelerated alfa-synuclein aggregation mediated by human microbiome-associated functional amyloids |
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Parkinson’s disease | alfa-synuclein | human microbiome | CsgA | native ion-mobility mass spectrometry
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Mineralocorticoid interaction with glycated albumin downregulates NRF – 2 signaling pathway in renal cells: Insights into diabetic nephropathy |
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Diabetic nephropathy | Aldosterone | Glycation
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Evolution of alfa-synuclein conformation ensemble toward amyloid fibril via liquid-liquid phase separation (LLPS) as investigated by dynamic nuclear polarization-enhanced solid-state MAS NMR |
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Synuclein | Liquid-liquid phase separation (LLPS) | Dynamic nuclear polarization (DNP)-Enhanced | MAS NMR
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Generalized Born Implicit Solvent Models Do Not Reproduce Secondary Structures of De Novo Designed Glu/Lys Peptides |
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Chemical Structure | Molecular Mechanics | Monomers | Peptides and proteins | Solvents
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Phosphatidylserine orchestrates Myomerger membrane insertions to drive myoblast fusion |
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Myomerger/Myomixer | myoblast fusion | phospatidylserine | membrane fusion
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Magnetoelectric dissociation of Alzheimer’s beta-amyloid aggregates |
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Crossref |
-
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An engineered SARS-CoV-2 receptor-binding domain produced in Pichia pastoris as a candidate vaccine antigen |
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SARS-CoV-2 | P. pastoris | COVID-19 | RBD | Subunit Vaccine
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Disordered–Ordered Protein Binary Classification by Circular Dichroism Spectroscopy |
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|
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Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction |
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-
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Hydration in Deep Eutectic Solvents Induces Non-monotonic Changes in the Conformation and Stability of Proteins |
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Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19 |
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-
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BeStSel: webserver for secondary structure and fold prediction for protein CD spectroscopy |
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-
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Interaction-Induced Structural Transformations in Polysaccharide and Protein-Polysaccharide Gels as Functional Basis for Novel Soft-Matter: A Case of Carrageenans |
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protein–polysaccharide gels; | -carrageenan; | galactan; | structure; | crosslinking; | FTIR-spectroscopy | molecular modelling; | novel matter
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Virus-like Particles: Fundamentals and Biomedical Applications |
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nanomedicine | nanotechnology | virus-like particles | preparation | characterization
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amyloid beta | coffee ring | deep learning | protein misfolding | self-assembly
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Engineering and Structural Insights of a Novel BBI-like Protease Inhibitor Livisin from the Frog Skin Secretion |
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protease inhibitor | antimicrobial peptide | natural product | skin secretions | animal venoms
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A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents |
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aminosterols | biotoxin neutralization | cell membranes | cellular resistance | pore-forming agents | steroid polyamines
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charge clustering | polyelectrolytes | average shape of conformational ensembles | charged-residue patterning | hydrodynamic radius | solvent-accessible surface area | proline content | conformational compactness; ellipsoid model
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Mucin-Type O-Glycosylation Proximal to beta-Secretase Cleavage Site Affects APP Processing and Aggregation Fate |
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Improved Stability of Human CGI-58 Induced by Phosphomimetic S237E Mutation |
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Peptides and proteins | Genetics | Monomers | Fluorescence | Aggregation
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Equilibrium Between Dimeric and Monomeric Forms of Human Epidermal Growth Factor is Shifted Towards Dimers in a Solution |
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Amino acid substitution | Dimer dissociation | Epidermal growth factor | Peptide dimerization | Secondary structure
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Chemistry and its Applications | Far Ultraviolet Circular Dichroism | melting temperature | Molecular Fluorescence | Near Ultraviolet Circular Dichroism | SARS-CoV-2S protein (RBD)-hFc | VCCA-2021
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Stability of oil-in-water emulsions improved by ovalbumin-procyanidins mixture: A promising substrate with emulsifying and antioxidant activity |
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Emulsion | Interaction | Ovalbumin (OVA) | Proanthocyanidins (PC) | Stability
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Požek
Požek
Požek
Požek
Požek
Požek
Požek
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Genomic Confirmation of the P-IIIe Subclass of Snake Venom Metalloproteinases and Characterisation of Its First Member, a Disintegrin-Like/Cysteine-Rich Protein |
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snake venom | Vipera ammodytes | disintegrin-like/cysteine-rich protein | gene structure | platelet aggregation | snake venom metalloproteinase (SVMP)
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Temperature and pH-Dependent Behaviors of mAb Drugs: A Case Study for Trastuzumab |
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thermal stability | conformational stability | colloidal stability | biophysical characterization | complementary tools
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In Vitro & In Vivo Studies on Identifying and Designing Temporin-1CEh from the Skin Secretion of Rana chensinensis as the Optimised Antibacterial Prototype Drug |
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Galleria mellonella larva model | antimicrobial activity | branched peptide | temporin
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Amyloid | Human calcitonin | Osteoporosis | Therapeutic peptide drug
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Structure-activity relationship of lipid, cyclic peptide and antigen rearrangement of physically mixed vaccines |
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Cyclic peptide | Group A Streptococcus | Lipid adjuvant | Physically mixed vaccines | Structure-immune activity relationship | Subunit vaccine
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An in-frame deletion mutation in the degron tail of auxin coreceptor IAA2 confers resistance to the herbicide 2,4-D in Sisymbrium orientale |
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TIR1/AFB | dicamba | herbicide resistance | plant hormones | target-site resistance
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Inhibitory effect of nucleotides on acetylcholine esterase activity and its microflow-based actuation in blood plasma |
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The Emergence of New Catalytic Abilities in an Endoxylanase from Family GH10 by Removing an Intrinsically Disordered Region |
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(beta/alfa)8-barrel domain | GH10 endoxylanase | intrinsically disordered region | new activities | protein dynamics
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| Seo et al. Proc Natl Acad Sci U S A (2022) |
Intragenic suppressors unravel the role of the SCREAM ACT-like domain for bHLH partner selectivity in stomatal development |
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ACT-like domain | bHLH proteins | cell-type differentiation | heterodimer | stomatal development
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Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates |
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Molecular and cellular insight into Escherichia coli SslE and its role during biofilm maturation |
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Disaggregation of Islet Amyloid Polypeptide Fibrils as a Potential Anti-Fibrillation Mechanism of Tetrapeptide TNGQ |
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aggregation | antidiabetic agents | bioactive peptides | biomolecular interaction | disaggregation | fibril formation | islet amyloid polypeptide | nutraceuticals
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Lysine-PEGylated Cytochrome C with Enhanced Shelf-Life Stability |
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bioconjugation | cytochrome-c | long-term stability | lysine PEGylation
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Enhanced Polychromatic Luminescence of Bionic Peptidyl Nanoparticles Driven by Hydrogen Bonds |
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aggregation-induced emission | bioimaging | ferrocene dipeptide | hydrogen bonds | nanoparticles
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The PCDDB (Protein Circular Dichroism Data Bank): A Bioinformatics Resource for Protein Characterisations and Methods Development |
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circular dichroism spectroscopy | data deposition and accession | protein stability and environmental effects | protein structural and spectroscopic database | resource for bioinformatics developments
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Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation |
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Kingella kingae PilC1 and PilC2 are adhesive multifunctional proteins that promote bacterial adherence, twitching motility, DNA transformation, and pilus biogenesis |
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Kingella kingae | Pili and fimbriae | Epithelial cells | Pathogen motility | Adhesives | Immune serum | Adhesins | Protein domains
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Poly-L-Arginine Molecule Properties in Simple Electrolytes: Molecular Dynamic Modeling and Experiments |
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Bioactive Low Molecular Weight Keratin Hydrolysates for Improving Skin Wound Healing |
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bioactive keratin | keratin hydrolysate | skin homeostasis restoration | skin wound healing
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Chemical synthesis and functional evaluation of the crayfish insulin-like androgenic gland factor |
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Insulin-like androgenic gland factor | Masculinization | Peptide synthesis | Procambarus virginalis
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| Honisch et al. Int J Mol Sci (2022) |
Effect of Trehalose and Ceftriaxone on the Stability of Aggregating-Prone Tau Peptide Containing PHF6* Sequence: An SRCD Study |
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ceftriaxone | conformational stability | intrinsically disordered proteins | protein aggregation | synchrotron radiation circular dichroism | tau protein | tauopathies | transmission electron microscopy; trehalose
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Formation and physicochemical properties of glycogen phosphorylase in complex with a cationic polyelectrolyte |
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Biophysical characterization | Cationic polyelectrolytes | Glycogen phosphorylase | Protein-polymer complexes
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Pex30 undergoes phosphorylation and regulates peroxisome number in Saccharomyces cerevisiae |
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ER | Mass spectrometry | Peroxisomes | Pex30 | Phosphorylation
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The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity |
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Parkinson’s disease | familial mutations | toxic oligomers | alfa-helical structure | alfa-synuclein
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| Foo et al. J Agric Food Chem (2022) |
Structure, Immunogenicity, and IgE Cross-Reactivity among Walnut and Peanut Vicilin-Buried Peptides |
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IgE epitopes | cross-reactivity | vicilin-buried peptide | alfa-hairpinin
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From Protein Design to the Energy Landscape of a Cold Unfolding Protein |
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X-rays | Molecules | Noncovalent interactions | Molecular structure | Alkyls
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MOSPD2 is an endoplasmic reticulum-lipid droplet tether functioning in LD homeostasis |
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| Wang et al. Chem Commun (2022) |
Rapid and label-free detection of aflatoxin B1 using a rationally truncated aptamer and via circular dichroism measurement |
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A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria |
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Inhibitor | Monooxygenase | Plumbagin | Tet(X) | Tetracycline
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| Scott et al. J Mol Biol (2022) |
Structure of the Anthrax Protective Antigen D425A Dominant Negative Mutant Reveals a Stalled Intermediate State of Pore Maturation |
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anthrax toxin | cryo-electron microscopy | intermediate state | pH-induced | pore maturation
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| Vincenzi et al. Bioorg Chem (2022) |
Targeting Ship2-Sam with peptide ligands: Novel insights from a multidisciplinary approach |
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Cancer | Cellular uptake | Docking | EphA2 | MST | NMR | SAM domains | SPR; Ship2
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Conotoxin-derived biomimetic coiled cone-shaped peptide as ligand for selective nanodelivery to norepinephrine transporter-expressing neuroblastoma cells |
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Apoferritin | Biomimetic peptides | Drug delivery | Neuroblastoma | Norepinephrine transporter | Targeted therapy
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| Ligorio et al. Acta Biomater (2022) |
Acidic and basic self-assembling peptide and peptide-graphene oxide hydrogels: characterisation and effect on encapsulated nucleus pulposus cells |
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3D cell culture | Nucleus pulposus | Peptide hydrogels | pH effect
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| Wu et al. ACS Macro Lett (2022) |
Ion-Triggered Hydrogels Self-Assembled from Statistical Copolypeptides |
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Peptides and proteins | Monomers | Chemical structure | Gelation | Hydrogels
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| Minenkova et al. Mol Ther (2022) |
Human inhalable antibody fragments neutralizing SARS-CoV-2 variants for COVID-19 therapy |
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COVID-19 pandemic | COVID-19 therapy | SARS-CoV-2 variant neutralization | aerosol therapy | anti-COVID-19 antibody | human single-chain antibody | inhalation | intranasal administration; phage display
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| Ovung et al. ACS Omega (2022) |
Heme Protein Binding of Sulfonamide Compounds: A Correlation Study by Spectroscopic, Calorimetric, and Computational Methods |
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Peptides and proteins | Monomers | Fluorescence | Molecules | Protein structure
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Controlling the conformational stability of coiled-coil peptides with a single stereogenic center of a peripheral b-amino acid residue |
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Deep Learning for Assignment of Protein Secondary Structure Elements from C Coordinates |
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protein modeling | secondary structure classification | C backbone | deep neural networks
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Membrane-disruptive engineered peptide amphiphiles restrain the proliferation of penicillins and cephalosporins resistant Vibrio alginolyticus and Vibrio parahaemolyticus in instant jellyfish |
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Antibacterial peptide | Vibrio | Drug-resistant strain | Membrane damage | Seafood
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LcaR: a regulatory switch from Pseudomonas aeruginosa for bioengineering alkane degrading bacteria |
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Alkane 1-monooxygenase | Alkane degradation | DNA binding protein | Pseudomonas aeruginosa | Transcription factor
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| Perlitz et al. Sensors (2022) |
Measurement of Secondary Structure Changes in Poly-L-lysine and Lysozyme during Acoustically Levitated Single Droplet Drying Experiments by In Situ Raman Spectroscopy |
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Raman sensor | in situ Raman spectroscopy | proteins | secondary structure changes | mathematical spectral reconstruction | acoustic levitation
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| Walter et al. FEBS J (2022) |
Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target |
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allostery | cryo-EM single particle analysis | crystal structure | enzyme regulation | nucleotide metabolism
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Deciphering the Mechanism of Interaction of an Ester-Functionalized Cationic Gemini Surfactant with Bovine Serum Albumin: A Biophysical and Molecular Modeling Study |
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C16-E2O2-C16 gemini surfactant | bovine serum albumin (BSA) | tensiometric analysis | site marker | computational analysis
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Malachite Green, the hazardous materials that can bind to Apo-transferrin and change the iron transfer |
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Apo-transferrin | Iron transfer | Malachite green oxalate | Molecular dynamic simulation | Multi-spectroscopy
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Injectable tissue integrating networks from recombinant polypeptides with tunable order |
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Dentin priming with amphipathic antimicrobial peptides |
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caries detection/diagnostic/prevention | imaging | materials science(s) | restorative materials | surface chemistry/properties
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Structural basis for the formation of soy protein nanofibrils |
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The regulatory role of sulfated polysaccharides in facilitating rhBMP-2-induced osteogenesis |
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Total Synthesis of Glycosylated Human Interferon- |
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Infectious diseases | Peptides and proteins | Carbohydrates | Ligation | Chemical biology
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Modulation of Peptide–Graphene Interfaces via Fatty Acid Conjugation |
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Small molecule induced toxic human-IAPP species characterized by NMR |
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Biophysical characterization of the homodimers of HomA and HomB, outer membrane proteins of Helicobacter pylori |
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Heterologous expression of four recombinant toxins from Panamanian scorpions of the genus Tityus and Centruroides for production of antivenom |
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Animal venom | Centruroides | Proteomics | Recombinant protein | Tityus
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Searching for the Best Transthyretin Aggregation Protocol to Study Amyloid Fibril Disruption |
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transthyretin | protein aggregation | amyloid fibrils | amyloidosis | amyloid disruptors | fibril disaggregation | screening protocol
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Inhibition of Islet Amyloid Polypeptide Fibrillation by Structurally Diverse Phenolic Compounds and Fibril Disaggregation Potential of Rutin and Quercetin |
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aggregation | disaggregation | fibril formation | islet amyloid polypeptide | phenolic compounds | structureactivity relationship
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The cysteine protease ApdS from Streptococcus suis promotes evasion of innate immune defenses by cleaving the antimicrobial peptide cathelicidin LL-37 |
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LL-37 | Streptococcus | Streptococcus suis | antimicrobial peptide (AMP) | cathelicidin | chemotaxis | cysteine protease | immune evasion; innate immunity; neutrophil
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A Stutter in the Coiled-Coil Domain of Escherichia coli Co-chaperone GrpE Connects Structure with Function |
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Bacteria | Genetics | Monomers | Assays | Hydrophobicity
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Computational redesign of the Escherichia coli ribose-binding protein ligand binding pocket for 1,3-cyclohexanediol and cyclohexanol |
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Interaction of Prion Peptides with DNA Structures |
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Peptides and proteins | Genetics | Fourier transform infrared spectroscopy | Lattices | Nucleic acid structure
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New findings on GFP-like protein application as fluorescent tags: Fibrillogenesis, oligomerization, and amorphous aggregation |
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Amorphous aggregates | Amyloid fibrils | Cytotoxicity | Fluorescent tags | Superfolder green fluorescent protein (sfGFP) | beta-barrel structure
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Conformational Consequences for Compatible Osmolytes on Thermal Denaturation |
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compatible osmolyte | disaccharide | hydration dynamics | thermal denaturation | time-dependent Stokes shift
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Evidence of Protein Binding by a Nucleopeptide Based on a Thyminedecorated L-Diaminopropanoic Acid through CD and In Silico Studies |
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3CLpro | CD | COVID-19 | Nucleopeptide | RNA-protein complex | SARS-CoV-2 | SEM | coronavirus infections; pandemics; protein binding
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Identification of methionine adenosyltransferase with high diastereoselectivity for biocatalytic synthesis of (S)-S-adenosyl-l-methionine and exploring its relationship with fluorinated biosynthetic pathway |
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(S)-S-adenosyl-l-methionine | Biocatalysis | Fluorometabolite biosynthetic pathway | Methionine adenosyltransferase | Streptomyces xinghaiensis
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Superior Proton-Transfer Catalytic Promiscuity of Cytochrome c in Self-Organized Media |
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Kemp elimination | biocatalytic promiscuity | cytochromec | membrane-mimetic system | protein unfolding
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Structural basis for osmotic regulation of the DNA binding properties of H-NS proteins |
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Purification and Characterization of Trehalase From Acyrthosiphon pisum, a Target for Pest Control |
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Acyrthosiphon pisum | Catalytic and structural properties | Molecular modelling | Trehalase
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Cellular Chaperone Function of Intrinsically Disordered Dehydrin ERD14 |
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CD spectroscopy | LEA protein | dehydrin | early response to dehydration | heat stress | intrinsic structural disorder | plant chaperone | structure-function relationship
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Structural and thermodynamic analyses of human TMED1 (p241) Golgi dynamics |
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Early secretory pathway | Protein secretion | Sorting receptors | TMED | p24 family
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| Miles et al. Protein Sci (2021) |
DichroWeb, a website for calculating protein secondary structure from circular dichroism spectroscopic data |
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bioinformatics | calculations | circular dichroism spectroscopy | data analyses | disordered structure | protein secondary structure | reference datasets | soluble and membrane proteins; alfa-helix; beta-sheet
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The leptospiral LipL21 and LipL41 proteins exhibit a broad spectrum of interactions with host cell components |
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Leptospira spp | LipL21 | LipL41 | leptospirosis | pathogenesis
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From Protein Corona to Colloidal Self-Assembly: The Importance of Protein Size in Protein–Nanoparticle Interactions |
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Entropy | Peptides and proteins | Adsorption | Silica | Phosphates
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| Mann et al. Biotechnol Bioeng (2021) |
Engineering human liver fatty acid binding protein for detection of poly- and perfluoroalkyl substances |
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biosensor | fatty acid binding protein | fluorescence | protein engineering | substrate specificity | tryptophan
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Molecular design of peptide amphiphiles for controlled self-assembly and drug release |
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-
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| Liu et al. Ultrason Sonochem (2021) |
Ultrasound-assisted Maillard reaction of ovalbumin/xylose: The enhancement of functional properties and its mechanism |
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Glycation | Ovalbumin | Structure characteristics | Surface properties | Ultrasound
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Caldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spines |
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caldendrin | endoplasmic reticulum | myosin | spine apparatus | synapse
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Thermoresponsive BSA hydrogels with phase tunability |
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Amyloid | BSA | Thermoresponsive hydrogel | beta-Fibril
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Size-responsive differential modulation in alfa-amylase by MPA-CdSe QDs: multispectroscopy and molecular docking study |
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CdSe | Semiconductor quantum dots | Mercaptopropionic acid | alfa-Amylase | Structure and function | Modulation
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New Factors Enhancing the Reactivity of Cysteines in Molten Globule-Like Structures |
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bovine serum albumin | chemical kinetics | chymotrypsinogen | cysteine reactivity | hydrophobic interaction | lysozyme | molten globule | oxidative folding; ribonuclease; transient complex
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Charge neutralization of lysine via carbamylation reveals hidden aggregation hotâ€spots in tau protein flanking regions |
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MD simulation | carbamylation | charge neutralization | flanking region | tau aggregation
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In Vitro and In Vivo Studies on the Antibacterial Activity and Safety of a New Antimicrobial Peptide Dermaseptin-AC |
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Dermaseptin | antimicrobial peptides | bacterial resistance
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Low modification of PETase enhances its activity toward degrading PET: Effect of conjugate monomer property |
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Polyethylene terephthalate | PETase | Low modification | Structural transformations | PET degradation | Enhanced catalytic performance
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Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum |
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Crossref |
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LPMO AfAA9_B and Cellobiohydrolase AfCel6A from A. fumigatus Boost Enzymatic Saccharification Activity of Cellulase Cocktail |
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AA9 LPMO | GH6 cellobiohydrolase | bioethanol | lignocellulose hydrolysis
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Unsaturated fatty acid-induced conformational transitions and aggregation of the repeat domain of tau |
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NMR spectroscopy | Tau | fatty acids | neurodegeneration | protein aggregation | protein–lipid interactions
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Oat Plant Amyloids for Sustainable Functional Materials |
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amyloid fibrils | functional amyloid materials | plant protein | reversible amyloid | sustainability
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Elastin-Like Peptide Dendrimers: Design, Synthesis, and Applications |
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Elastin-Like Peptide | Dendrimer | Hydrogel | H2S | Peptide-Polymer conjugate
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Accurate Machine Learning Prediction of Protein Circular Dichroism Spectra with Embedded Density Descriptors |
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Peptides and proteins | Monomers | Circular dichroism spectroscopy | Protein structure | Polarity
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Molecular structural heterogeneity of bisphenols governs their serum albumin binding |
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Bisphenols | Blood | Structural heterogeneity | Protein conformation | Molecular docking
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Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids |
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Biophysics | Virology | protein folding
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Dual amyloid cross-seeding reveals steric zipper-facilitated fibrillization and pathological links between protein misfolding diseases |
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Hybrid Nanocoatings of Self-assembled Organic-Inorganic Amphiphiles for Prevention of Implant Infections |
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CD spectroscopy | CueR | DNA | Metal ion | Solution secondary structure
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C terminus of myosin 16 | backfolding interaction | intrinsically disordered | molten globule | myosin 16 | tryptophan fluorescence
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Anti-oxidant | Dopamine metabolism | Neuromelanin | PRKN/PARK2 gene | Parkin | Parkinsonism | Redox chemistry | Young-onset Parkinson disease
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Hfq | antibacterial compound | apomorphine | bacterial adaptation | bacterial amyloid | functional amyloid | protein fibrillation inhibition | protein fibrils
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Bacillus subtilis | TasA | extracellular matrix | functional amyloid | protein aggregation
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Amino acid | Fluoroalcohol | Formic acid | Organic solvent | Protein | Solubility
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Aggregation | Amyloid | Deltamethrin | Lysozyme | Neurodegeneration
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Biophysical method | Circular dichroism spectroscopy | Monte Carlo-like model | Secondary structure analysis | Uncertainty estimation
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E. coli | GATA4 | Protein expression and purification | Recombinant protein | Secondary structure
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MglB | MglC | Myxococcus xanthus | RLC7 family | SAXS | bacterial motility | cell polarity | isothermal calorimetry; polarity reversal; protein–protein interactions
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ITC | NMR spectroscopy | X-ray crystallography | heme oxygenase | structural biology
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3D homology modeling | Influenza virus hemagglutinin cytoplasmic tail | circular dichroism | fluorescence spectroscopy | intrinsic disorder
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antimicrobial peptide | arenicin | complement regulation | complement system
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Lipids | Crystal structure | Dimers | Liposomes | Centrifugation | Cloning | Dimerization | Sequence alignment
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SRCD and FTIR Spectroscopies to Monitor Protein-Induced Nucleic Acid Remodeling |
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Nucleoprotein complex | Helical properties | Sugar puckering | Chiro-optical spectroscopy | Vibrational spectroscopy | RNA and protein secondary structure
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Nano-Bio Interaction between Blood Plasma Proteins and Water-Soluble Silicon Quantum Dots with Enabled Cellular Uptake and Minimal Cytotoxicity |
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cell imaging | conformational changes | plasma proteins | quantum dots | silicon
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Ebola glycoprotein | Ebola virus | glycoprotein | recombinant vaccine | trimeric protein | vaccine.
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acyl carrier protein | fungal nonreducing polyketide synthase | macrocyclic polylactone | small-angle X-ray scattering | thioesterase
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BeStSel: From Secondary Structure Analysis to Protein Fold Prediction by Circular Dichroism Spectroscopy |
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Circular dichroism | Protein secondary structure | Protein fold | Amyloid | beta-sheet
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2,2-dipyridyl disulfide | evasin-3 | native chemical ligation | thiazolidine
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Metal nanoparticles | Peptides and proteins | Fourier transform infrared spectroscopy | Circular dichroism spectroscopy | Conjugate acid-base pairs
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BH3 | Bcl-xL | Bim peptides | DEER | EPR | X-ray | apoptosis
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Peptides and proteins | Absorption | Fluorescence | Carbon nanotubes | Particulate matter
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Dictyostelium discoideum | Friedreich’s Ataxia | conformational stability | iron–sulfur cluster assembly | protein–protein interaction
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Self organization | Supramolecular structures and assemblies | Hydrophilicity | Hydrophobicity | Hydrogels
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Kohonen algorithm | XGBoost algorithm | circular dichroism | nnet algorithm | nucleic acids secondary structure prediction
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NMR spectroscopy | intrinsically disordered protein | liquid–liquid phase separation | membraneless organelle
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antigen-specific | insulin | type 1 diabetes | immunotherapy | multivalent | B cell | anergy
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Amyloid formation | Fluorescence spectroscopy | Helical intermediate | Protein aggregation | Tau
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cryoTEM | molecular dynamics | protein corona | protein unfolding | silica nanoparticles | synchrotron-radiation circular dichroism
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Aggregation | Anastellin | Extracellular matrix | Fibronectin | Peroxynitrous acid | Protein oxidation
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Human Serum Albumin in the Presence of AGuIX Nanoagents: Structure Stabilisation without Direct Interaction |
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circular dichroism | gadolinium | nanoparticle | protein | stability | structure
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Alzheimers disease | BiOCl nanosheets | Piezoelectric materials | beta-amyloid
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protein-polymer, light scattering, lower critical solution temperature, thermodynamics, van’t Hoff, engraftment
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DEER-detected p13(II) self-association | Fluorescence-based p13(II) liposome uptake assay | High-yield protein production | Human T-cell leukemia virus type 1 encoded protein p13(II) | Viral protein-mitochondrial membrane association
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Protein folding | Size-exclusion chromatography | Malarial parasites | Malaria | Protein structure prediction | Circular dichroism spectroscopy | Monomers | Protein structure
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Thermal stability analyses of human PERIOD-2 C-terminal domain using dynamic light scattering and circular dichroism |
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Dimers | Crystal structure | Thermal stability | Hydrodynamics | Disulfide bonds | Oligomers | Circadian rhythms | Circular dichroism spectroscopy
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CO2 capture | carbonic anhydrase | circular dichroism | fluorescence | greenhouse gases
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circular dichroism spectroscopy | cryogenic transmission electron microscopy | intrinsically disordered proteins | magnesium transporter | membrane proteins | molecular-dynamics simulations | protein–vesicle interactions | secondary structure; small-angle X-ray scattering
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Molecular Dynamics Ensemble Refinement of Intrinsically Disordered Peptides According to Deconvoluted Spectra from Circular Dichroism |
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Ajmalicine and Reserpine: Indole Alkaloids as Multi-Target Directed Ligands Towards Factors Implicated in Alzheimers Disease |
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Alzheimer’s disease | Abeta | BACE-1 | MAO-B | ajmalicine | molecular docking | multi target directed ligand | rauwolfia serpentina; reserpine
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pH-Induced Changes in Polypeptide Conformation: Force-Field Comparison with Experimental Validation |
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Electrophoresis | Peptides and proteins | Molecules | Molecular mechanics | Nucleic acid structure
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Site-Specific Interactions with Copper Promote Amyloid Fibril Formation for 6aJL2-R24G |
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Nanofibers | Peptides and proteins | Copper | Monomers | Ions
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Musashi-1: An Example of How Polyalanine Tracts Contribute to Self-Association in the Intrinsically Disordered Regions of RNA-Binding Proteins |
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RNA-binding proteins | intrinsically disordered proteins | liquid–liquid phase separation | polyalanine | self-association
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branched peptides | circular dichroism | fibrillation | sinapic acid | supramolecular interactions | valine
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Allosterism | Fluorescence studies | Lipoxygenases | Molecular dynamics | Protein–protein interactions | Secondary structure
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The Effect of Fatty Acids and BSA Purity on Synthesis and Properties of Fluorescent Gold Nanoclusters |
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Au nanocluster | cell viability | fatty acid | palmitic acid | serum albumin
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Phosphorylation of a Disordered Peptide-Structural Effects and Force Field Inconsistencies |
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Peptides and proteins | Molecular mechanics | Conformation | Cell and molecular biology | Post-translational modification
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RNA structure | Chiro-optical spectroscopy | Small noncoding RNA | DsrA
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Assessing the effect of aromatic residue placement on the alfa-helical peptide structure and nanofibril formation of 21-mer peptides |
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Biophysical characterization of p53 core domain aggregates |
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aggregation | amyloid | cancer | p53
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Validation of l-Tellurienylalanine as a Phenylalanine Isostere |
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amino acids | isosteres | mass cytometry | probe design | tellurium
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Disentangling the role of solvent polarity and protein solvation in folding and self-assembly of alfa-lactalbumin |
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Alcohols | Amyloid aggregation | Molecular dynamics | Protein hydration | Protein-protein Interactions | Smallangle X-ray scattering
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Inhibiting Human Calcitonin Fibril Formation with Its Most Relevant Aggregation-Resistant Analog |
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Nanofibers | Peptides and proteins | Aggregation | Assays | Kinetics
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Tracking amyloid oligomerization with monomer resolution using a 13-amino acid peptide with a backbone-fixed spin label |
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VHH characterization.Recombinant VHHs: Production, characterization and affinity |
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Affinity | CD | Characterization | Differential scanning fluorimetry | Expression | Hydrogen/deuterium exchange | Ion-mobility | Mass spectrometry; Structure; Surface plasmon resonance; VHH
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SERF engages in a fuzzy complex that accelerates primary nucleation of amyloid proteins |
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Alzheimer’s | chaperone | protein folding
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Recombinant Pyriform Silk Fiber Mechanics Are Modulated by Wet-Spinning Conditions |
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recombinant pyriform silk | silk protein structure and morphology | strong and extensible fibers | tunable mechanical properties | wet-spinning and automated postspin draw
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Zn(II) binding causes interdomain changes in the structure and flexibility of the human prion protein |
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The Impact of Rare Human Variants on Barrier-To-Auto-Integration Factor 1 (Banf1) Structure and Function |
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BANF1 | DNA binding | human variants | nuclear envelope | nuclear integrity
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Nanoencapsulation as a General Solution for Lyophilization of Labile Substrates |
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HRP | freeze-drying | lyophilization | tES | thermostable exoshells
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Unravelling the effect of N()-(carboxyethyl)lysine on the conformation, dynamics and aggregation propensity of alfa-synuclein |
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Singular value decomposition analysis of the secondary structure features contributing to the circular dichroism spectra of model proteins |
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Amyloid fibrils | Secondary structure | Singular value decomposition
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Unprecedented coupling of natural rubber and ELP: synthesis, characterization and self-assembly properties |
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Insight into the Binding and Hydrolytic Preferences of hNudt16 Based on Nucleotide Diphosphate Substrates |
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DSF | GppG | IDP | MST | SAXS | dinucleoside diphosphates | hNudt16 | nudix family
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ALS-linked FUS mutations dysregulate G-quadruplex-dependent liquid-liquid phase separation and liquid-to-solid transition |
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ALS (amyotrophic lateral sclerosis) | FUS (fused in sarcoma) | G-quadruplex | LLPS (liquid–liquid phase separation) | LST (liquid-to-solid transition)
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Deep-UV resonance Raman spectroscopy of hydrated and dehydrated model alfa-helical transmembrane peptides in liposomes |
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Altered Peptide Self-Assembly and Co-Assembly with DNA by Modification of Aromatic Residues |
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Peptides | aromatic interactions | self-assembly | transfection
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Self-Assembly Pathways and Antimicrobial Properties of Lysozyme in Different Aggregation States |
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Nanofibers | Peptides and proteins | Antimicrobial activity | Bacteria | Aggregation
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The Introduction of a Cysteine Residue Modulates The Mechanical Properties of Aromatic-Based Solid Aggregates and Self-Supporting Hydrogels |
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aromatic peptides | cysteine oxidation | hydrogels | peptide materials | self-assembling
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Analysis of amyloid-like secondary structure in the Cryab-R120G knock-in mouse model of hereditary cataracts by two-dimensional infrared spectroscopy |
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Cataracts | Optical lenses | Amyloid proteins | Protein structure | Tempering | Vibration | Amides | Mouse models
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Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel |
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Structure of prion beta-oligomers as determined by short-distance crosslinking constraint-guided discrete molecular dynamics simulations |
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molecular modeling | protein aggregation | protein folding | structural proteomics
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Blood, sweat, and tears: extraterrestrial regolith biocomposites with in vivo binders |
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3D-printing | BSA, Bovine Serum Albumin | Biopolymer-bound soil composites | CD, Circular Dichroism | ERB, Extraterrestrial Regolith Biocomposite | FE-SEM, Field-emission Scanning Electron Microscopy | HSA, Human Serum Albumin | Human serum albumin; Hybrid materials; In situ resource utilization; LHS-1, Lunar Highlands Simulant 1; MGS-1, Martian Global Simulant 1; MSA, Mammalian Serum Albumin; Recombinant spider silk
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Differential ligand-selective control of opposing enzymatic activities within a bifunctional c-di-GMP enzyme |
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bifunctional enzyme | cyclic di-GMP | heme sensor
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Microbial production of megadalton titin yields fibers with advantageous mechanical properties |
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Design and structural bioinformatic analysis of polypeptide antigens useful for the SRLV serodiagnosis |
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Antigen design | Circular dichroism | ELISA test | Modelling and structural analysis | Molecular dynamics | Protein clustering | SRLV serodiagnosis
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Characterization of recombinant beta subunit of human MUC4 mucin (rMUC4beta) |
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Marine Transcriptomics Analysis for the Identification of New Antimicrobial Peptides |
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venomous fish | lionfish | antimicrobial peptides | transcriptomic
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DisCoTune: versatile auxiliary plasmids for the production of disulphide-containing proteins and peptides in the E. coli T7 system |
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Bioevaluation of Pheretima vulgaris Antithrombotic Extract, PvQ, and Isolation, Identification of Six Novel PvQ-Derived Fibrinolytic Proteases |
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Edman degradation | LC-MS/MS | Pheretima vulgaris | fibrinolytic activity | gene cloning | isolation | structural identification
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Type F mutation of nucleophosmin 1 Acute Myeloid Leukemia: A tale of disorder and aggregation |
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Acute Myeloid Leukemia | Aggregation | Internally disordered regions | Wide-angle X-ray scattering
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Unfolding Mechanisms and Conformational Stability of the Dimeric Endophilin N-BAR Domain |
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Peptides and proteins | Genetics | Monomers | Protein structure | Fluorescence resonance energy transfer
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Membrane Association Modes of Natural Anticancer Peptides: Mechanistic Details on Helicity, Orientation, and Surface Coverage |
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anticancer peptides | flow-linear dichroism | molecular dynamics | peptide conformation | spectroscopy
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Iron Cycle Tuned by Outer-Membrane Cytochromes of Dissimilatory Metal-Reducing Bacteria: Interfacial Dynamics and Mechanisms In Vitro |
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OmcA | capacitor | electron transfer | hematite | iron reduction | photoresponse
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A Novel Peptide Derived from the Transmembrane Domain of Romo1 Is a Promising Candidate for Sepsis Treatment and Multidrug-Resistant Bacteria |
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AMPR-11 | Romo1 | drug resistance | multidrug-resistant bacteria | peptide antibiotics | sepsis
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Diphenylalanine Motif Drives Self-Assembling in Hybrid PNA-Peptide Conjugates |
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assembly | beta sheet | fluorescence | peptide | peptide nucleic acid
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Revealing the importance of carrier-cargo association in delivery of insulin and lipidated insulin |
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Carrier peptide | Histology | Insulin | Intestinal delivery | Lipidated cargo | Mechanism | Membrane interaction | Penetramax
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Enzyme-Instructed Formation of beta-Sheet-Rich Nanoplatelets for Label-Free Protease Sensing |
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peptide self-assembly | protease detection | legumain | thioflavin T | label-free sensing | beta-sheet
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Correlating solvation with conformational pathways of proteins in alcohol-water mixtures: a THz spectroscopic insight |
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A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid-liquid phase separation to promote oncogenic YAP signaling |
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Amphiphilic Histidine-Based Oligopeptides Exhibit pH-Reversible Fibril Formation |
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Self organization | Nanofibers | Peptides and proteins | Monomers | Chemical structure
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An ornithine-rich dodecapeptide with improved proteolytic stability selectively kills gram-negative food-borne pathogens and its action mode on Escherichia coli O157:H7 |
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Antimicrobial peptides | Food preservative | Lipopolysaccharide-binding | Membrane depolarization | Membrane potential
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An artificial membrane binding protein-polymer surfactant nanocomplex facilitates stem cell adhesion to the cartilage extracellular matrix |
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Articular cartilage repair | Cell adhesion | Cell membrane re-engineering | Protein-polymer surfactant complex | Stem cell therapy
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Elevated temperatures accelerate the formation of toxic amyloid fibrils of hen egg-white lysozyme |
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amyloid fibrils | elevated temperatures | hen egg-white lysozyme | prion | protein unfolding
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Electrospun Nanofibrous Architectures of Thrombin-Loaded Poly(ethylene oxide) for Faster in Vivo Wound Clotting |
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biomaterials | wound healing | electrospinning | nanofibers | hemostasis
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Baicalein Ameliorates Streptococcus suis-Induced Infection In Vitro and In Vivo |
34072443
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Streptococcus suis | anti-hemolysin | antibacterial | baicalein | suilysin
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Construction and Application of EGCG-Loaded Lysozyme/Pectin Nanoparticles for Enhancing the Resistance of Nematodes to Heat and Oxidation Stresses |
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Caenorhabditis elegans | EGCG | lysozyme | nanoparticles | pectin | stress defense
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alfa-Helices in the Type III Secretion Effectors: A Prevalent Feature with Versatile Roles |
34063760
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4-alfa-helix bundle | Leucine-Rich Repeat (LRR) | Novel E3 Ligase (NEL) | Transcription Activator-Like Effector (TALE) | Type III Secretion System (T3SS) | Type III Secretion effector (T3SE) | coiled coil | dictionary of secondary structure in proteins (DSSP)
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BING, a novel antimicrobial peptide isolated from Japanese medaka plasma, targets bacterial envelope stress response by suppressing cpxR expression |
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Molecular model of a sensor of two-component signaling system |
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Preparation, purification and identification of iron-chelating peptides derived from tilapia (Oreochromis niloticus) skin collagen and characterization of the peptide-iron complexes |
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Tilapia skin collagen hydrolysate | Iron-chelating peptides | Peptide-iron complexes | Structure | Bio-accessibility
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Expression, purification and characterization of the IcmG and IcmK proteins of the type IVB secretion system from Coxiella burnetii |
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Antigen | Coxiella burnetti, secretion system type IV | IcmG | IcmK | Membrane proteins | Q fever
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Influence of Hydrogen Bond and Sodium Alginate on Bovine Serum Albumin Adhesion on ZnSe Surface |
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Bovine serum albumin | Attenuated total reflection Fourier transform infrared spectroscopy | Hydrogen bond | Sodium alginate
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Multiple system atrophy-associated oligodendroglial protein p25alfa stimulates formation of novel alfa-synuclein strain with enhanced neurodegenerative potential |
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Multiple system atrophy (MSA) | P25alfa | Protein aggregation | Strains | Tubulin polymerisation-promoting protein (TPPP) | -Synuclein
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Formulation matters! A spectroscopic and molecular dynamics investigation on the peptide CIGB552 as itself and in its therapeutical formulation |
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atomic force microscopy imaging | fluorescence spectroscopy of peptides | molecular dynamics simulation | peptide aggregation | peptide fibrillation | therapeutic peptide
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Polyamine-Responsive Morphological Transformation of a Supramolecular Peptide for Specific Drug Accumulation and Retention in Cancer Cells |
34114343
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cucurbituril | morphology transformation | polyamine-responsive | self-assembly | supramolecular-peptide
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Membrane Anchored Polymers Modulate Amyloid Fibrillation |
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amyloid beta fibrillation | lipid-polymer conjugate | stimuli-responsive polymers
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Design and Engineering of Amyloid Aggregation-Prone Fragments and Their Antimicrobial Conjugates with Multi-Target Functionality |
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Complexation of exenatide and cyclodextrin: An approach for the stabilization and sustained release of exenatide in PLGA microsphere |
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Cyclodextrin | Exenatide | Extended release | In vivo | Interaction | Stability
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Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma |
33971243
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Crystallography | G-protein coupled receptor kinase 6 | Multiple myeloma | Palmitoylation | Structure-guided drug design
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Modulation of von Willebrand Factor Function by Domain C4 Mutations |
34592780
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von Willebrand factor | hypercoagulability | GPIIb/IIIa
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Investigation of the effects of two major secretory granules components, insulin and zinc, on human-IAPP amyloid aggregation and membrane damage |
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C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition |
33888826
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Computational generation of proteins with predetermined three-dimensional shapes using ProteinSolver |
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Bioinformatics | Biophysics | Circular Dichroism (CD) | Protein Biochemistry | Protein expression and purification | Structural Biology
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Total Synthesis and Structural Characterization of Caveolin-1 |
33825275
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bicelles | membrane proteins | palmitoylation | thioester method | total synthesis
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Higher Order Analysis of Protein Structure of Therapeutic Monoclonal Antibody by Circular Dichroism Spectroscopy |
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Monoclonal antibody products | Biosimilars | Secondary protein structure | Tertiary protein structure
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Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimers Disease beta Secretase, BACE1 |
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Alzheimer’s disease | BACE1 | Litopenaeus vannamei | amyloid-beta | chondroitin sulfate | glycosaminoglycan | heparan sulphate | heparin, beta-secretase
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The Effect of Oxidized Dopamine on the Structure and Molecular Chaperone Function of the Small Heat-Shock Proteins, alfaB-Crystallin and Hsp27 |
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Hsp27 | Parkinson’s disease | cross-linking | dopamine | molecular chaperone | oxidation | post-translational modification | small heat-shock protein, alfaB-crystallin
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Protein-nanoparticle interactions and a new insight |
33885450
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Crossref |
-
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Apigenin and Ampicillin as Combined Strategy to Treat Severe Streptococcus suis Infection |
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STSLS | Streptococcus suis | ampicillin | apigenin | inflammation
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Quantum Plasmonic Sensors |
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Interfaces | Sensors | Metals | Plasmonics | Quantum mechanics
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Non-Aggregating Amylin Fragments as an Inhibitors of the Aggregation Process of Susceptible to Aggregation Fragments 18-22, 23-27, and 33-37 of Hormone |
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aggregation | amylin | amylin non-aggregating fragment | destabilization of ordered peptide structures | peptidic inhibitors of aggregation
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A novel beta-hairpin peptide derived from the ARC repressor selectively interacts with the major groove of B-DNA |
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ARC repressor | Conformational analysis | DNA major groove binders | Transcription factors | beta-hairpin peptides
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Disease variants of human 1-pyrroline-5-carboxylate reductase 2 (PYCR2) |
33771508
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Circular dichroism | Product inhibition kinetics | Proline biosynthesis | Protein thermostability | Steady-state kinetics | Substrate-binding order | (1)-pyrroline-5-carboxylate reductase
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VEGF and VEGFR2 bind to similar pH-sensitive sites on fibronectin, exposed by heparin-mediated conformational changes |
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VEGFR2 | acidic | angiogenesis | extracellular matrix | fibronectin | heparin | hypoxia | surface plasmon resonance (SPR), vascular endothelial growth factor (VEGF)
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Glucosamine and Its Analogues as Modulators of Amyloid-beta Toxicity |
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Nanofibers | Cell signaling | Peptides and proteins | Oligomers | Toxicity
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Site-Specific Introduction of Negative Charges on the Protein Surface for Improving Global Functions of Recombinant Fetal Hemoglobin |
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DNA cleavage | fetal hemoglobin | plasma half-life | protein engineering | protein surface charge | small-angle X-ray scattering
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Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes |
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African Sleeping Sickness | Trypanosoma brucei | autoinhibition | crystal structure | cysteine protease | fluorescence correlation spectroscopy (FCS) | molecular dynamics | proenzyme, rhodesain, zymogen
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Microfluidic fabrication of wrinkled protein microcapsules and their nanomechanical properties affected by protein secondary structure |
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Microfluidics | Microcapsule | Nanoindentation | Wrinkle | Protein secondary structure
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A Comparative Study of the Effects of Platinum (II) Complexes on beta-Amyloid Aggregation: Potential Neurodrug Applications |
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amyloid aggregation | anti-aggregation properties | metallodrugs | platinum (II) compounds
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A Super Stable Mutant of the Plant Protein Monellin Endowed with Enhanced Sweetness |
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high intensity sweeteners | sensory analysis | shelf life | single-chain monellin (MNEI) | sweet proteins | thermochemical stability
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Enhancing the stability of Geobacillus zalihae T1 lipase in organic solvents and insights into the structural stability of its variants |
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Lipases | Molecular simulations | Mutagenesis | Organic solvent | Stability
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Composition of the Protein Ingredients from Insoluble Oat Byproducts Treated with Food-Grade Enzymes, Such as Amylase, Cellulose/Xylanase, and Protease |
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circular economy | enzymatic treatment | oat press cake | phenols | plant proteins | plant-based beverages
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Under Conditions of Amyloid Formation Bovine Carbonic Anhydrase B Undergoes Fragmentation by Acid Hydrolysis |
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acid hydrolysis | amyloid | carbonic anhydrase | peptides | size-exclusion chromatography
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| Yang et al. Food Chem (2021) |
Effect of glycation degree on the structure and digestion properties of ovalbumin: A study of amino acids and peptides release after in vitro gastrointestinal simulated digestion |
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Amino acid | Digestibility | Glycation | Ovalbumin | Peptide
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In Vitro Oxidative Crosslinking of Recombinant Barnacle Cyprid Cement Gland Proteins |
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Adhesion | Barnacle | Cement | Cyprid | Lysyl oxidase | Recombinant
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Load phycocyanin to achieve in vivo imaging of casein-porous starch microgels induced by ultra-high-pressure homogenization |
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Fluorescence imaging | Microgels | Phycocyanin | Porous starch | Zebrafish
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Structural and functional insights of GSU0105, a unique multiheme cytochrome from G. sulfurreducens |
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Receptor binding, immune escape, and protein stability direct the natural selection of SARS-CoV-2 variants |
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ACE2 | COVID-19 | SARS-CoV-2 | antibodies | protein binding | protein expression | protein function | protein stability, protein structure, variants
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Structural Alterations of Antigens at the Material Interface: An Early Decision Toolbox Facilitating Safe-by-Design Nanovaccine Development |
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Alhydrogel® | BM4 | Bet v 1 | SiO2 | allergen | alum | silica nanoparticles | structural integrity
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A single sulfatase is required to access colonic mucin by a gut bacterium |
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| Cheropkina et al. Biochem Pharmacol (2021) |
Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate |
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Drug metabolism | Flavin-containing monooxygenase | ROS | Spectroscopy | Stopped-flow | Uncoupling
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| Zhang et al. Food Hydrocolloids (2021) |
Ions-induced ovalbumin foaming properties enhancement: Structural, rheological, and molecular aggregation mechanism |
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Ovalbumin | Ions | Foaming properties | Structure characteristics | Rheological properties
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Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa |
34498587
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Pseudomonas aeruginosa | SiaC | SiaD | crystal structure | infectious disease | microbiology | molecular biophysics | structural biology
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Identification of Optimal Expression Parameters and Purification of a Codon-Optimized Human GLIS1 Transcription Factor from Escherichia coli |
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Force Field Effects in Simulations of Flexible Peptides with Varying Polyproline II Propensity |
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Peptides and proteins | Molecular mechanics | Conformation
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Exploring the Propensities of Fluorescent Carbazole Analogs toward the Inhibition of Amyloid Aggregation in Type 2 Diabetes: An Experimental and Theoretical Endeavor |
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Peptides and proteins | Fluorescence | Aggregation | Inhibition | Aromatic compounds
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Liquid-liquid phase separation underpins the formation of replication factories in rotaviruses |
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RNP granules | biomolecular condensates | microfluidics | viral genome assembly
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Human Fibrinogen Inhibits Amyloid Assembly of Most Phenol-Soluble Modulins from Staphylococcus aureus |
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Biofilms | Nanofibers | Peptides and proteins | Chemical structure | Nucleation
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Development of a Broad-Spectrum Antiserum against Cobra Venoms Using Recombinant Three-Finger Toxins |
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antiserum | broad spectrum | cobra | immunization | recombinant protein | three finger toxins
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Insights into the binding interaction mechanism of 12,12-dihydrochromeno[2,3-c]isoquinolin-5-amine in bovine serum albumin and prostaglandin H2 synthase-1: A biophysical approach |
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Tyrosine O-GalNAc Alters the Conformation and Proteolytic Susceptibility of APP Model Glycopeptides |
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APP | Alzheimer’s disease (AD) | CD analysis | O-glycosylation | proteolytic cleavage | tyrosine
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Genesis of Neurotoxic Hybrid Nanofibers from the Coassembly of Aromatic Amino Acids |
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amyloid cross-seeding | amyloid mimicking nanostructure | aromatic amino acids | coassembly | hybrid nanofiber | neurotoxicity
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Collagenase Activity of Bromelain Immobilized at Gold Nanoparticle Interfaces for Therapeutic Applications |
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bromelain | collagen | cysteine protease | gold nanoparticles | nanotechnology
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Striking Dependence of Protein Sweetness on Water Quality: The Role of the Ionic Strength |
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MNEI | single chain monellin mutants | sweet proteins | sweet receptor | thaumatin | wedge model
|
| Pandey et al. Cell Mol Life Sci (2021) |
Flexible microtubule anchoring modulates the bi-directional motility of the kinesin-5 Cin8 |
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Bi-directional motility | Cin8 | Context-dependent directionality reversal | Kinesin-5 | Motor–microtubule interaction
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Identification of a Zika NS2B epitope as a biomarker for severe clinical phenotypes |
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Development of a Potential Yeast-Based Vaccine Platform for Theileria parva Infection in Cattle |
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East Coast Fever | Theileria parva | oral vaccine | schizont antigens | yeast
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A Novel Leptospira interrogans Protein LIC13086 Inhibits Fibrin Clot Formation and Interacts With Host Components |
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Leptospira | fibrin clot inhibition | host pathogen interaction | leptospirosis | recombinant protein
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Tools and methods for circular dichroism spectroscopy of proteins: a tutorial review |
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The food additive fast green FCF inhibits alfa-synuclein aggregation, disassembles mature fibrils and protects against amyloid-induced neurotoxicity |
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Anti-EGFR V HH Antibody under Thermal Stress Is Better Solubilized with a Lysine than with an Arginine SEP Tag |
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SEP tag | VHH | aggregation | arginine SEP tag | lysine SEP tag | protein solubility | single domain antibody
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Macromolecular Crowding Effect on the Activity of Liposome-Bound Alkaline Phosphatase: A Paradoxical Inhibitory Action |
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-
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| Arnittali et al. Int J Mol Sci (2021) |
Structure and Thermal Stability of wtRop and RM6 Proteins through All-Atom Molecular Dynamics Simulations and Experiments |
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RM6 | Rop | biomolecules | molecular dynamics simulations | mutations | proteins | secondary structure | thermostability
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Genetic Dominant Variants in STUB1, Segregating in Families with SCA48, Display In Vitro Functional Impairments Indistinctive from Recessive Variants Associated with SCAR16 |
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CHIP | E3 ubiquitin ligase | SCA48 | SCAR16 | STUB1 | spinocerebellar ataxia
|
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Biochemical and Initial Structural Characterization of the Monocot Chimeric Jacalin OsJAC1 |
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OsJAC1 | carbohydrate-binding | dirigent domain | lectin | melting point | monocot chimeric jacalin
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Assessing the Interactions of Statins with Human Adenylate Kinase Isoenzyme 1: Fluorescence and Enzyme Kinetic Studies |
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adenylate kinase | atorvastatin | fluorescence spectroscopy | fluvastatin | inhibitors | pleiotropic effect | pravastatin | rosuvastatin, simvastatin
|
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Physicochemical Characterization Cascade of Nanoadjuvant-Antigen Systems for Improving Vaccines |
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adjuvants | antigens | characterization | vaccines
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Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast |
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-
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Identification and functional analysis of cadmium-binding protein in the visceral mass of Crassostrea gigas |
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Crossref |
-
|
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PDZ Sample Quality Assessment by Biochemical and Biophysical Characterizations |
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PDZ domain | Folding | Protein sample | Quality control | Biophysical techniques | Stability | Purity | Identity,Structure,Quantification
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A thermophilic, pH-tolerant, and highly active GH10 xylanase from Aspergillus fumigatus boosted pre-treated sugarcane bagasse saccharification by cellulases |
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GH10 xylanase | Aspergillus fumigatus | Lignocellulose | Saccharification | Synergy | Central composite rotational design
|
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Biosimilars accessible in the market for the treatment of cancer |
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Biosimilars | biologics | cancers | clinical trials | marketed product | safety
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DeepnsSNPs: Accurate prediction of non-synonymous single-nucleotide polymorphisms by combining multi-scale convolutional neural network and residue environment information |
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Non-synonymous single-nucleotide polymorphisms | Single nucleotide variants | Disease-causing nsSNPs | Multi-scale convolutional neural network | Residue environment information
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Pepsin Digest of Gliadin Forms Spontaneously Amyloid-Like Nanostructures Influencing the Expression of Selected Pro-Inflammatory, Chemoattractant, and Apoptotic Genes in Caco-2 Cells: Implications for Gluten-Related Disorders |
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aggregates | celiac disease | gliadins oligomers | gluten-related disorder | peptide oligomers
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Structure of Nanobody Nb23 |
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NMR | immunoglobulin domain | nanobody | protein structure
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Cell-free expression of the outer membrane protein OprF of Pseudomonas aeruginosa for vaccine purposes |
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Crossref |
-
|
| Dash et al. J Pharm Biomed Anal (2021) |
Freeze thaw and lyophilization induced alteration in mAb therapeutics: Trastuzumab as a case study |
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Aggregation | Antibodydependent cellular cytotoxicity (ADCC) | Charge heterogeneity | Freeze-thaw | Lyophilization | Surface plasmon resonance (SPR)
|
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Alpha-Helical Protein KfrC Acts as a Switch between the Lateral and Vertical Modes of Dissemination of Broad-Host-Range RA3 Plasmid from IncU (IncP-6) Incompatibility Group |
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IncU (IncP-6) group | active partition | alpha-helical KfrC protein | broad-host-range RA3 plasmid | conjugative transfer
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Trypsinogen and chymotrypsinogen: the mysterious hyper-reactivity of selected cysteines is still present after their divergent evolution |
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chymotrypsinogen | cysteine reactivity | molten globule | oxidative folding | trypsinogen
|
| Xu et al. ACS Omega (2021) |
Conformational Change and Activity Enhancement of Rabbit Muscle Lactate Dehydrogenase Induced by Polyethyleneimine |
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Peptides and proteins | Absorption | Fluorescence | Polyethylenimine | Conformation
|
| Fukui et al. J Biol Chem (2021) |
An alfa-synuclein decoy peptide prevents cytotoxic alfa-synuclein aggregation caused by fatty acid binding protein 3 |
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amyloid fibrils | fatty acid binding protein 3 | protein aggregation | synuclein-fatty acid binding protein 3 complex | alfa-synuclein
|
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Generation of biologically active recombinant human OCT4 protein from E. coli |
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E. coli | OCT4 | Protein expression | Protein purification | Recombinant protein | Secondary structure
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Naphthalimide-Containing BP100 Leads to Higher Model Membranes Interactions and Antimicrobial Activity |
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BP100 | antimicrobial peptide | biological activity | calorimetry | model membranes | naphthalimide | spectroscopy
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Soluble expression, purification, and secondary structure determination of human PDX1 transcription factor |
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BL21(DE3) | E. coli | Heterologous expression and purification | PDX1 | Recombinant protein | Secondary structure
|
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Hydroxyl radical induced structural perturbations make insulin highly immunogenic and generate an auto-immune response in type 2 diabetes mellitus |
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Autoimmunity | Diabetes | Free radicals | Insulin | Protein aggregation | Reactive oxygen species
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EGFR extracellular domain III expressed in Escherichia coli with SEP tag shows improved biophysical and functional properties and generate anti-sera inhibiting cancer cell growth |
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Disulfide bond | Escherichia coli expression | Immunogenicity | Neutralizing antibody | Solubility
|
| Shao et al. Cell Commun Signal (2021) |
A new type of flexible CP12 protein in the marine diatom Thalassiosira pseudonana |
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Coiled coil | Diatom | Intrinsically disordered protein IDP | Nuclear magnetic resonance | Photosynthesis | Small angle X-ray scattering
|
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Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms |
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Genomics | Treponema pallidum | Syphilis | Outer membrane proteins | Bacterial genomics | Bacterial pathogens | Pathogenesis | Virulence factors
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A Tryptophan Gate in the CRISPR-Cas3 Nuclease Controls ssDNA Entry into the Nuclease Site, That When Removed Results in Nuclease Hyperactivity |
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CRISPR | Cas3 | genome editing | helicase
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Unraveling the implications of multiple histidine residues in the potent antimicrobial peptide Gaduscidin-1 |
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insulin | chitosan | mucoadhesive | buccal films | synchrotron radiation circular dichroism | FTIR-microspectroscopy | in vivo
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Albumin | Binding constants | Conformational change | Nano-bio interface | Protein corona | alfa-1-Acid glycoprotein
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Annexin V/ PI | Apoptosis | CD spectroscopy | Docking | FTIR spectroscopy | Fluorescence spectroscopy
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PscD/SctD | PscK/SctK | basal body | sorting platform | type III secretion system
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Antifreeze proteins | Dynamic ice shaping | Ice recrystallization inhibition | Ice-binding proteins | pH
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Nanofibers | Peptides and proteins | Monomers | Aggregation | Kinetics
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Self-assembly | Beta-amyloid | Neurodegenerative disease | Microscopy | Spectroscopy | Scattering | Biomolecule
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Allostery | Circular dichroism | Enzyme assay | Exonuclease | Intrinsic disorder
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Accuracy improvement | CD prediction | CD spectroscopy | Model validation | SESCA | SS estimation
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Analytical ultracentrifugation | Circular dichroism spectroscopy | IB kinase | Multi-angle light scattering | NEMO | NF-B | Size-exclusion chromatography
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Torpedo californica | Nicotinic acetylcholine receptor | Lipid-like detergent complex | Circular dichroism | Fluorescence recovery after photobleaching
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Peptides and proteins | Monomers | Surface interactions | Molecules | Deposition
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RT-PCR | alternative splicing | heparin cofactor II | novel isoform | serpin
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Supramolecular structures and assemblies | Fibers | Peptides and proteins | Aromatic compounds | Transmission electron microscopy
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BibA | C4b-binding proteins | group B streptococcus | immunogenic bacterial adhesins | three-helix-bundle-motif repeats
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d-ribose | Fibrinogen | advanced glycation end products (AGEs) | glycation
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Biological function | Molecular imaging | Molecular structure | Therapeutic monoclonal antibodies
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amphibian skin secretion | antimicrobial peptide | hydrophobicity | structure-activity relationship
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Endosome | Intrinsic activity | Metastasis | RT-NMR | Rab GTPase
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FTIR spectroscopy | Protein selection | Protein spectroscopy | Secondary structure
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aggregation | amyloid beta-peptides | copper | neurodegeneration | protein-protein interactions
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Alzheimer’s disease | Amyloid | aggregation | inhibitor | metal ions | neurotoxicity
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CNTF | intravitreal delivery | neuroprotection | protein aggregation | retinal penetration | stability
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CD spectroscopy | IM30 | Mg2+ | Vipp1 | membrane binding | membrane fusion | pH | quartz crystal microbalance; thylakoid membrane
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Azobenzene | Peptides and proteins | Chemical structure | Conformation | Computational chemistry
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FTIR spectroscopy | curve fitting | infrared spectroscopy | ionic liquid | nanoparticles | secondary structure | silk fibroin
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Peptides and proteins | Chemical structure | Solvents | Conformation | Molecular structure
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Alzheimers disease | amyloid beta-peptides | fluorescence | inhibitors | oligomerization
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gold nanoparticles | nanoparticle stability | peptide amphiphiles | self-assembled monolayer | beta-sheet
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Curcumin | Fibrinogen | Hyaluronic acid | Light scattering | Polysaccharide-protein nanoparticles | Thermal treatment
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Pulsed light | Pectinmethylesterase | Enzyme inactivation | Protein structure | Inactivation kinetics | fruit juices
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conformations | glycans | structural studies | synthetic oligosaccharides
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Silk-elastinlike protein | drug delivery | matrix-metalloproteinase | nanogel | thermoresponsive
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lysozyme | amyloid fibrils | nanoparticles | spectroscopy | toxicity
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Glycation | Maillard reaction | Bovine serum albumin | Aggregation | Mass spectrometry
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Bullous pemphigoid | Circular dichroism | Hemidesmosome | Induced folding
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DNA helicase | OB-fold | PXXP motif | RecG | SH3 domain | SSB interactome | single-strand binding protein
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Beta-Glucosidase | Spectroscopy | Loop Region | Molecular Dynamics simulation
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Actin | Capping protein | Heterodimer | Homodimer | Malaria | Plasmodium
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Bioconversion | Deep eutectic solvent | Ginsenoside CK | Talaromyces purpureogenus | beta-Glucosidase
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Treponema | bovine digital dermatitis | outer membrane proteins | reverse vaccinology
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bioluminescence | imaging agents | optical reporters
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Anabaena | Nostoc sp. PCC 7120 | PRP | Rfr fold | cyanobacteria | pentapeptide repeat protein | protein crystal structure | repeat five residue fold
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Anti-infection | Isoalantolactone | Penicillin G | beta-Lactamase-positive S. aureus | beta-lactamase inhibitor
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Alphavirus | Chikungunya virus | Lipid nanotube | Liposome | Membrane rearrangement | Membrane-binding peptide | Non-structural protein 1 | Spherule; nsP1
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Intrinsic disorder | Kinetics | Self-assembly
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Multispectroscopic and Computational Analysis Insight into the Interaction of Cationic Diester-Bonded Gemini Surfactants with Serine Protease alfa-Chymotrypsin |
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fibrillation kinetics | Abeta | alfa-synuclein | IAPP | amylin | oligomers | protofibrils
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cyclic peptide | self-assembly | chiral center | ring size | nanostructure | supramolecules | supercapacitor
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chemometric methods | circular dichroism | flagellar associated protein 174 | Fourier transform infrared spectroscopy | partial least square regression
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6×His tag | DNA hydrolysis | Mass spectrometry | NColE7 nuclease | Zinc(II)
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Parkinson’s disease | alpha-synuclein | amyloid | cinnamic acid derivatives | fibrillization
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Immunology | Cells | Peptides and proteins | Biopolymers | Dendrons
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Ca(2+)-binding protein | MAp | PDZ domain | S100A4 | X-ray crystallography | annexin A2 | crystallization chaperon | metastasis; p53; protein-protein interaction
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B-cell lymphoma 2 (Bcl-2) family | BCL-2-associated X apoptosis regulator (BAX) | Bax | apoptosis | conformational change | electron microscopy | fibers | fibril; fibrillation; humanin; mitochondrial apoptosis; protein aggregation; beta-sheet
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alfa-synuclein | Carbon nanotube | Gold nanoparticle | Protein self-assembly | Soft robotics
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chain length | micelle formation | molecular dynamics | protein-surfactant interactions | unfolding mechanisms
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Rapeseed proteins | Plant proteins | Oil bodies | Oleosomes | Emulsifiers | Oil-in-water systems
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Biochemical Characterization of Homoserine Dehydrogenase from Pseudomonas aeruginosa |
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Homoserine dehydrogenase | Pseudomonas aeruginosa
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Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors |
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Alzheimer’s disease | Anti-inflammatory | Tau anti-aggregation | Usnic acid derivatives
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Pathogenesis-relatedprotein1 (PR-1) | conformational structure | adjuvant | dendritic cells (DCs) | peptide antigens | B cell epitope
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protein-protein interactions | protein purification | protein complexes | protein binding affinity
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Aggregation | Biopharmaceutics | Fibrillation | Peptides
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anticancer peptide | antimicrobial peptide | dermaseptin | frog skin secretion | molecular cloning
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Peptides and proteins | Circular dichroism spectroscopy | Chemical structure | Conformation | Nucleic acid structure
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Aggregation | SPPS | amyloid deposits | amyloid-like fiber formation | diabetes | triazine coupling reagents
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antimicrobial peptide | thermal responsiveness | adsorption kinetics | dye leakage
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Alzheimer’s disease | N--(carboxyethyl)lysine (CEL) | advanced glycated end product (AGE) | amyloid-beta (Abeta) | fibril | glycation | mitochondria | neurodegeneration
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Structural and functional characterization of fast-cycling RhoF GTPase |
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Bacterial Amyloids |
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Cell signaling | Sensors
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The Transmembrane Conformation of the Influenza B Virus M2 Protein in Lipid Bilayers |
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Alzheimers disease | Langmuir film balance | amyloid-beta peptide | membrane insertion | shedding
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In Situ Characterization of Hfq Bacterial Amyloid: A Fourier-Transform Infrared Spectroscopy Study |
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FTIR | Hfq | bacterial amyloid | functional amyloid | protein fibrillation inhibition | protein fibrils
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bacterial CotA laccase | bioelectrocatalysis | oxygen reduction | seawater | photo-biovoltaics
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New Recombinant Cold-Adapted and Organic Solvent Tolerant Lipase from Psychrophilic Pseudomonas sp. LSK25, Isolated from Signy Island Antarctica |
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Antarctica | Pseudomonas sp. LSK25 | cold adapted lipase | organic solvent tolerant | purification
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Urea | Fluorescence | Denaturation | Acetylation | Tryptophan | Protein denaturation | Mycobacterium tuberculosis | Protein structure
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Affinity chromatography | Circular dichroism | Colicin E7 | Mass spectrometry | Ni(II)-Induced cleavage
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bioconjugation | cell adhesion | lipid-protein conjugates | lipids | protein modifications
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Calorimetry | Combinations of analytical approaches | Computation | Microscopy | Protein-surfactant interactions | Spectroscopy and spectrometry
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cell adhesion modulation | fibronectin | polyelectrolyte multilayer | protein adsorption | thermal annealing
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Spectroscopic study of conformation changes of bovine serum albumin in aqueous environment |
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5-nucleotidase | ATPase activity | Inorganic salt | organic solvent
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Biosorption | Metallo-chaperone | Pb(II) | PbrD protein
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Crown ether modified peptide interactions with model membranes |
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Membrane active peptides | crown ethers | antimicrobial peptides | oriented circular dichroism | supramolecular assembly
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Ovalbumin Epitope SIINFEKL Self-Assembles into a Supramolecular Hydrogel |
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amyloid fibrils | buffer-specific effects | lysozyme
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Seeding and Cross-Seeding Aggregations of Abeta 40 and Its N-Terminal-Truncated Peptide Abeta 11-40 |
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Amyloid beta-peptide | N-terminal truncated peptide | seeding | cross-seeding | surface aggregation
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Glycation | Peptide | alfa-Helix
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Ice-Binding Protein from Shewanella frigidimarinas Inhibits Ice Crystal Growth in Highly Alkaline Solutions |
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alkalinity | ice recrystallization inhibition | ice-binding protein | ionic strength
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amino acids | nucleic acids | proteins | saccharides | structural analysis
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Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 with the Polysulfonated Drug Suramin: A Step Closer to in Vivo Complexity |
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IR spectroscopy | antimicrobial peptides | circular dichroism | folding | suramin
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Anuran antimicrobial peptides | Peptide modifications | Selectivity index
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Biophysical and structural characterization of the small heat shock protein HspA from Thermosynechococcus vulcanus in 2 M urea |
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Chaperone | Cyanobacteria | Denaturation | Heat shock protein | X-ray crystallography
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Steric Repulsion Forces Contributed by PEGylation of Interleukin-1 Receptor Antagonist Reduce Gelation and Aggregation at the Silicone Oil-Water Interface |
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PEGylation | adsorption | interactions | physical stability | protein aggregation | protein formulation(s) | rheology
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Acid-denatured small heat shock protein HdeA from Escherichia coli forms reversible fibrils with an atypical secondary structure |
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Gram-negative bacteria | acid denaturation | amyloid | molecular chaperone | periplasm | protein aggregation | protein fibrillogenesis | protein folding
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Encapsulation of the Dinuclear Trithiolato-Bridged Arene Ruthenium Complex Diruthenium-1 in an Apoferritin Nanocage: Structure and Cytotoxicity |
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anticancer | diruthenium | drug delivery | ferritin | protein cages
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Supramolecular Tuning of H 2 S Release from Aromatic Peptide Amphiphile Gels: Effect of Core Unit Substituents |
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Peptides and proteins | Monomers | Substituents | Aromatic compounds | Hydrogels
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Effects of EGCG on Amyloid beta-Protein Fibrillogenesis and Cytotoxicity at Different pH Values |
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Amyloid beta-protein | Aggregation | pH | (-)-epigallocatechin-3-gallate | Inhibition
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Aggregation | Glycation | Hydrophobicity | THP-1 macrophage | Thermal processing | Uptake | beta-Lactoglobulin
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One fold, two functions: cytochrome P460 and cytochrome c-beta from the methanotroph Methylococcus capsulatus (Bath) |
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protein evolution | methanotroph | anammox | metalloproteins | gas sensors | hydroxylamine
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Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions |
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3BP-2 | ABI2 | ABL tyrosine kinase | Src homology 3 domain (SH3 domain) | X-ray crystallography | ligand binding | nuclear magnetic resonance (NMR) | phosphotyrosine signaling
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Low-resolution structure, oligomerization and its role on the enzymatic activity of a sucrose-6-phosphate hydrolase from Bacillus licheniformis |
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Bacillus licheniformis | Biochemical properties | Sucrose-6-phosphate hydrolase | beta-Fructofuranosidase
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Ni(II), Hg(II), and Pb(II) Coordination in the Prokaryotic Zinc-Finger Ros87 |
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Zinc | Peptides and proteins | Metals | Monomers | Ions
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Single-Molecule Förster Resonance Energy Transfer Measurement Reveals the Dynamic Partially Ordered Structure of the Epidermal Growth Factor Receptor C-Tail Domain |
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Structural dynamics | Peptides and proteins | Chemical structure | Fluorescence resonance energy transfer | Nucleic acid structure
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Silver Ion-Histidine Interplay Switches Peptide Hydrogel from Antiparallel to Parallel beta-Assembly and Enables Controlled Antibacterial Activity |
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Silver ion | Histidine | Parallel beta-sheet | Controlled release | Antibacterial
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Design and characterization of a self-assembling protein nanoparticle displaying HIV-1 Env V1V2 loop in a native-like trimeric conformation as vaccine antigen |
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ALF | Conformational antibody | HIV-1 | Nanovaccine | SAPN | V1V2 | Vaccine
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A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia |
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DISC1 L607F mutation | atomic force microscopy | immunohistochemistry | oligomerization | prepulse inhibition
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Directed Evolution of Canonical Loops and Their Swapping between Unrelated Serine Proteinase Inhibitors Disprove the Interscaffolding Additivity Model |
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SPINK1 | directed evolution | molecular recognition | phage display | protein–protein interaction
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Design and assessment of an active anti-epidermal growth factor receptor (EGFR) single chain variable fragment (ScFv) with improved solubility |
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Epidermal growth factor receptor | SEP tag | Single chain variable fragment | Solubilization | Yield
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Production and characterization of recombinant P1 adhesin essential for adhesion, gliding, and antigenic variation in the human pathogenic bacterium, Mycoplasma pneumoniae |
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Circular dichroism (CD) | Electron microscopy | Hydrodynamics | Sialic acid receptor | Small-angle X-ray scattering (SAXS) | Structure modeling
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An EmrB multidrug efflux pump in Burkholderia thailandensis with unexpected roles in antibiotic resistance |
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EmrB | MarR | antibiotic | bacterial virulence | gene regulation | multidrug resistance | multidrug transporter | oxidative stress
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Epigallocatechin Gallate Remodelling of Hfq Amyloid-Like Region Affects Escherichia coli Survival |
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Hfq | antibacterial | bacterial adaptation | bacterial amyloid | epigallocatechin gallate (EGCG) | functional amyloid | protein fibrillation inhibition | protein fibrils
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Characterisation of sensor kinase by CD spectroscopy: golden rules and tips |
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circular dichroism | ligand interaction | membrane sensor kinase
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Long circulating genetically encoded intrinsically disordered zwitterionic polypeptides for drug delivery |
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Bioinspired materials | Recombinant proteins | Unstructured polypeptides | Zwitterionic polypeptides
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Efficient synthesis and characterisation of the amyloid beta peptide, Abeta 1-42, using a double linker system |
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Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism |
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Disordered Peptides Looking for Their Native Environment: Structural Basis of CB1 Endocannabinoid Receptor Binding to Pepcans |
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CB1 endocannabinoid receptor | endocannabinoid system | hemopressin | intrinsically unfolded peptides | pepcans | structure-activity relationships
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The transient production of anti-TNF-alfa antibody Adalimumab and a comparison of its characterization to the biosimilar Cinorra |
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Adalimumab | CHO-Cells | HEK-293T | Transient expression
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Zinc boosts EGCGs hIAPP amyloid Inhibition both in solution and membrane |
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Amyloid | Epigallocatechin-gallate | Islet amyloid polypeptide | Membrane | Protein aggregation | Type II diabetes
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Crystal Structure of Chloroplastic Thioredoxin f2 from Chlamydomonas reinhardtii Reveals Distinct Surface Properties |
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Calvin-Benson cycle | Chlamydomonas reinhardtii | carbon fixation | chloroplast | electrostatic surface | macromolecular crystallography | photosynthesis | protein-protein recognition
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Experimental Characterization of Fuzzy Protein Assemblies: Interactions of Paramyxoviral N TAIL Domains With Their Functional Partners |
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ESI-MS and IM-MS | Experimental assessment of fuzziness | Fuzzy interactions | Impact of fuzziness on binding | Kinetics | Mutagenesis | NMR | SAXS
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Copper Induced Radical Dimerization of alfa-Synuclein Requires Histidine |
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Peptides and proteins | Copper | Organic reactions | Aggregation | Nucleic acid structure
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Functional annotation of operome from Methanothermobacter thermautotrophicus H: An insight to metabolic gap filling |
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Functional genomics | Gap fills | Genome-scale model | Hypothetical protein | Methanobacterium | Methanogenesis | Operome | Systems biology
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Rorippa indica HSPRO2 expression in transgenic Brassica juncea induces tolerance against mustard aphid Lipaphis erysimi |
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Rorippa indica | RiHSPRO2 protein | Lipaphis erysimi | Transgenic Brassica juncea | Aphid tolerance | In planta insect bioassay
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Atomistic Details of Chymotrypsin Conformational Changes upon Adsorption on Silica |
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circular dichroism | conformational changes | free energy | molecular dynamics | protein adsorption | silica
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Disordered Regions of Mixed Lineage Leukemia 4 (MLL4) Protein Are Capable of RNA Binding |
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HOTAIR | MEG3 | MLL proteins | MLL4 | RNA binding | histone lysine methyltransferase | intrinsically disordered protein | leukemia
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C-Terminal Cu II Coordination to alfa-Synuclein Enhances Aggregation |
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EPR spectroscopy | N-Acetylated alfa-synuclein | Parkinson’s disease | aggregation | metal dyshomeostasis | missense mutation
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G-Protein Coupled Receptor Protein Synthesis on a Lipid Bilayer Using a Reconstituted Cell-Free Protein Synthesis System |
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G-protein coupled receptor | artificial cell | cell-free protein synthesis | lipid bilayer | lipid nanodisc | membrane protein
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Amyloid-peptide beta 42 Enhances the Oligomerization and Neurotoxicity of apoE4: The C-terminal Residues Leu279, Lys282 and Gln284 Modulate the Structural and Functional Properties of apoE4 |
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Alzheimer’s disease | amyloid-peptide beta (Abeta) | apolipoprotein E4 (apoE4) | biophysics | neurotoxicity | oligomerization
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Functional characterization of isolated RNA-binding domains of the GRSF1 protein |
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Electrophoretic mobility shift assays | Protein expression | Protein purification | RNA metabolism | qRRMs
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Sample Volume Reduction Using the Schwarzschild Objective for a Circular Dichroism Spectrophotometer and an Application to the Structural Analysis of Lysine-36 Trimethylated Histone H3 Protein |
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Schwarzschild objective | beam focusing | histone | post-translational modification | structural alteration
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Microfluidic fabrication of wrinkled protein microcapsules and their nanomechanical properties affected by protein secondary structure |
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Microcapsule | Microfluidics | Nanoindentation | Protein secondary structure | Wrinkle
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Amyloid fibers deriving from the aromatic core of C-terminal domain of nucleophosmin 1 |
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Acute Myeloid Leukemia | Amyloid aggregation | Wide-Angle X-ray Scattering
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Design of Lipid–Protein Conjugates Using Amphiphilic Peptide Substrates of Microbial Transglutaminase |
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lipid | peptide | self-assembly | lipidprotein conjugate | microbial transglutaminase
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Expressing a Monomeric Organophosphate Hydrolase as an EK Fusion Protein |
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Interfaces | Peptides and proteins | Oligomers | Protein dynamics | Stability
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Studies of membranotropic and fusogenic activity of two putative HCV fusion peptides |
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Fusogenic properties | HCV fusion peptides | Membranotropic properties | Microscopy | Spectrofluorescence
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Isolation and purification of recombinant immunoglobulin light chain variable domains from the periplasmic space of Escherichia coli |
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Optical lenses | Recombinant proteins | Cardiomyocytes | Contaminants | Amyloidosis | Protein expression | Antibodies | Osmotic shock
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The Use of Surfactants to Solubilise a Glucagon Analogue |
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SDS | biosurfactants | helicity | isothermal titration calorimetry | solubility
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Structural insight into the mechanism of action of antimicrobial peptide BMAP-28(1-18) and its analogue mutBMAP18 |
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Amphipathicity | Antimicrobial peptide (AMP) | Electron Microscopy (EM) | Membrane anchoring | Molecular dynamics (MD) | Nuclear Magnetic Resonance (NMR)
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A valine-to-lysine substitution at position 210 induces structural conversion of prion protein into a beta-sheet rich oligomer |
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Amyloid | Prion | Protein aggregation | Protein folding
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Amentoflavone Ameliorates Streptococcus suis-Induced Infection In Vitro and In Vivo |
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Streptococcus suis | amentoflavone | anti-inflammation | antivirulence | suilysin
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Interactions of Fly Ash Particles with Mucin and Serum Albumin |
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Fundamental interactions | Reaction products | Fluorescence | Nanoparticles | Quenching
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The lipid mediator lysophosphatidic acid induces folding of disordered peptides with basic amphipathic character into rare conformations |
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Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP 2 |
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NMR | PACSIN | PIP(2) | SH3 domain | Syndapin | TRP channel | TRPV4 | cis proline
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Comparative Analysis of TM and Cytoplasmic beta-barrel Conformations Using Joint Descriptor |
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The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn 2+ Ligands and Roles in Damage Recognition and Repair |
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Peptides and proteins | Ligands | Genetics | Monomers | Rodent models
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Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells |
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Antimicrobial peptide | Cell viability. | Dermaseptin | Molecular cloning | Skin secretion
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Quantification of Intrinsically Disordered Proteins: A Problem Not Fully Appreciated |
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UV absorbance | circular dichroism | coomassie brilliant blue | elemental analysis | error propagation | nanoorange | ninhydrin | protein concentration
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Andrographolide inhibits human serum albumin fibril formations through site-specific molecular interactions |
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Development of Vacuum-Ultraviolet Circular-Dichroism Spectrophotometer Using Synchrotron Radiation and Structural Analysis of Biomolecules |
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Structural Characterization of the Lactobacillus Plantarum FlmC Protein Involved in Biofilm Formation |
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LytR-CpsA-psr | biofilm | lactic acid bacteria | probiotics
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Bacillus subtilis HelD, an RNA Polymerase Interacting Helicase, Forms Amyloid-Like Fibrils |
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Bacillus subtilis | HelD | SEC-SAXS | amyloid fibrils | intracellular amyloids | oligomerization
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Molecular Insights into Functional Differences between mcr-3- and mcr-1-Mediated Colistin Resistance |
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colistin resistance | homology modeling | mcr-1 | mcr-3 | phosphatidylethanolamine
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Design of antimicrobial peptides from a cuttlefish database |
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Antimicrobial peptides | Design | Predictive tools | Sepia officinalis | Transcriptome
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Nanofibers | Peptides and proteins | Monomer | Fluorescence | Oligomers
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Analytical pyrolysis to gain insights into the protein structure. The case of ovalbumin |
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Amyloids | Bacterial biofilm proteins | Curli | Nanomaterials
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Functional amyloid | Noncoding RNA cofactor | Protein self-assembly
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3E10 | Autoantibody | DNA damage repair | Di-scFv | Synthetic lethality
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Drosophila | Huntingtons disease | spinocerebellar ataxias
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AA amyloidosis | Amyloid fibril | Carboxyl-terminal truncation | Native chemical ligation | Serum amyloid A
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ATCC | American Type Culture Collection
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N(TAIL) | XD | induced folding | major inducible heat shock protein (hsp70) | measles virus
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Endo-1,4-beta-xylanase | Enzymatic hydrolysis | Molecular modeling | Purification | Xylooligosaccharides
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Vesicles | Inorganic compounds | Genetics | Monomers | Group 13 compounds
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CM15 | bilirubin | biliverdin | circular dichroism spectroscopy | fluorescence quenching | hemin | intrinsic disorder | melittin
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High hydrostatic pressure | Rhizopus chinensis lipase | Native-like state | Denaturation | Aggregation
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COS7(gp91-p22) cells | Cell-free system | NADPH oxidase | Nox2 | Superoxide anions
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micellar casein | powder | secondary structure | solubility | storage
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immunogenicity | lumazine synthase | polyvalent antigen display | ricin | stability | vaccine
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Im7 immunity protein | SRCD spectroscopy | colicin E7 nuclease | induced protein folding
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Helicase | CD | NMR | Protein-protein interaction
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Brassica juncea | phytocystatine | circular dichroism | isothermal calorimetry | protein–protein docking
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amyloid fibrils | ultrasonication | insulin | beta2-microglobulin | molten globule | protein misfolding | supersaturation | thioflavin T
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NADPH oxidase | arachidonic acid | circular dichroism | superoxide production | thiol groups
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CHOK1SV GS-KO | Fc fusion protein | VEGFR1(D1–D3)-Fc | biological activity | clipping | folded | inhibition | proteolysis
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Nanofibers | Peptides and proteins | Monomers | Oligomers | Organic compounds
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